Navigation Links
Study offers insights into role of muscle weakness in Down syndrome
Date:12/17/2012

BETHESDA, Md. (Dec. 17, 2012)It is well known that people with Down syndrome (DS) suffer from marked muscle weakness. Even the simple tasks of independent living, such as getting out of a chair or climbing a flight of stairs, can become major obstacles. This can reduce the quality of life for those with DS and lead to a loss of independence. Now, a new study sheds light on some of the suspected causes of muscle weakness.

Led by scientists from Syracuse University, a research team has investigated muscle weakness in a mouse model of DS. "If we understand the cause of this muscle weakness, we can begin to look at potential therapies for treating it," said Patrick M. Cowley, lead researcher.

The investigators analyzed the soleus musclea muscle in the lower legand looked into whether the weakness was due to a deficiency of the muscle itself, independent of its activation by the nervous system.

"Surprisingly, we found that the strength of the muscle itself was the same between the DS and control micesuggesting that factors in the nervous system may play a more dominant role in explaining muscle weakness in DS," said Cowley.

The article is entitled "Functional and Biochemical Characterization of the Soleus Muscle in Down Syndrome Mice: Insight into the Muscle Dysfunction Seen in the Human Condition," (http://bit.ly/TXsmby) It appears in the online edition of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology published by the American Physiological Society (APS).

Methodology

The researchers removed soleus muscles from 14 DS mice and 16 controls. They tested the muscles for strength, fatigue and recovery. They also assessed the distribution of fiber types in muscles from both groups.

Because there are three copies instead of two of chromosome 21 in persons with DS, the researchers looked at whether th
'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... – Bacteria in the gastrointestinal tract fulfill many ... these same bacteria can induce strong inflammatory responses ... gut and enter the bloodstream. , Although acute ... body, chronic or systemic inflammation is linked to ... the involvement of inflammatory processes in the development ...
(Date:10/30/2014)... 2014  Securus Technologies, a leading provider ... for public safety, investigation, corrections and monitoring, ... enhancements to its THREADS™ product, which utilizes ... intelligence and focused leads for investigators. ... innovation through identifying and delivering solutions serving ...
(Date:10/29/2014)... its kind to date, researchers have used DNA sequencing ... for autism. Joseph Buxbaum, Ph.D., Icahn School of Medicine ... Broad Institute of Harvard and MIT, and their colleagues ... parents and unrelated people. They identified changes in 107 ... for autism spectrum disorder (ASD) – a jump from ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2
... Institute for Research in Immunology and Cancer (IRIC) at ... quantity of laboratory stem cells from a small number ... multidisciplinary team, directed by Dr. Guy Sauvageau, thus took ... treatment based on these stem cells. This worldwide first ...
... kind study examining the effects of methamphetamine use during pregnancy ... in children. The research is published in the April 15, ... of the American Academy of Neurology. "Methamphetamine ... leading to an increasing number of children with prenatal meth ...
... In acute ischemic stroke, the blood supply to the ... of oxygen. In addition, ischemia activates harmful inflammatory processes ... first time, scientists at the Neurology Clinic at Heidelberg ... the blood inhibit inflammation after a stroke. These cells ...
Cached Biology News:World premiere in stem cell research in Montreal 2Prenatal meth exposure linked to abnormal brain development 2'First aid' for brain cells comes from blood 2
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... The report "Data Center Networking ... Equipment, WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts ... center networking market into various segments with an ... also identifies the factors driving this market, various ... with the future roadmaps. , Browse 106 market ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4
... Wis. - Building efficiency and power solutions giant ... of its executive positions reflecting the creation an Executive ... president, was named chairman of the EOC, a committee ... since 1982, Roell served as vice president and chief ...
... at a Pennsylvania teaching and research hospital are integrating ... to distribute information about diabetes, cancer, heart disease, and ... S. Hershey Medical Center recently purchased the Web-based ... forums, and internal staff meetings to medical students and ...
... is a concept that appears a long way from ... genetic-based medicine is closer than we think. , ,In ... identify the patient's predisposition to various diseases, and to ... environmental characteristics. , , Stephens Cracking ...
Cached Biology Technology:Medical College researcher working to make genetic-based medicine a reality 2Medical College researcher working to make genetic-based medicine a reality 3
... has a long and outstanding history ... Several years ago we became aware ... was being modified to inject Xenopus ... redesigning the microdispenser to eliminate any ...
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
Rabbit polyclonal to Synapsin II ( Abpromise for all tested applications). entrezGeneID: 6854 SwissProtID: Q92777...
... primers are designed for sequencing inserts cloned ... T7, or T3 RNA polymerase promoters, or ... supplied at a concentration of 0.1 µg/µl ... in DNA sequencing reactions using SequiTherm™ EXCEL™ ...
Biology Products: