Navigation Links
Study offers first explanation of how cells rapidly repair and maintain structure

SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell. The research has implications for cancer, as well as other diseases, since alterations in the cytoskeleton are often associated with disease. The research was published in the Sep. 14, 2010, issue of the journal Developmental Cell.

"Just like people, the cells in our bodies are exposed to all kinds of stress," says Mary Beckerle, Ph.D., the study's principal investigator and HCI executive director. "One type of stress, mechanical stress that is derived from application of physical force, is experienced by many organs such as the lung, which stretches with each breath, the heart, which is physically challenged with each beat, and the uterus, which undergoes intense contractions during labor and childbirth. We were interested in how living cells respond to such stress. In this study, we showed that mechanical stress can damage the cytoskeleton but that cells have special machinery that rapidly recognizes the damage and repairs it."

Mark Smith, Ph.D., one of the HCI researchers involved in the study explains that, "When a cell's environment changes and stress is applied, cytoskeletal bundles, called actin stress fibers, can literally begin to tear, but then are rapidly repaired. This process begins within seconds and allows the cell to retain its structure. We showed that a protein called zyxin is required for the maintenance and repair of the actin cytoskeleton." Zyxin expression is down-regulated in certain cancers and future experiments will explore whether loss of this cytoskeletal repair pathway in tumor cells is responsible for the disruption of the cytoskeleton that is common in cancer cells.

The researchers studied the process by imaging live cells that expressed fluorescently tagged cytoskeletal proteins. This allowed them to observe the mechanism whereby actin stress fibers maintain homeostasis, or balance. The repair mechanism was directly triggered by force and served to relieve mechanical stress on actin stress fibers, which in turn provided a system for rapid response to force changes in the extracellular environment.


Contact: Linda Aagard
University of Utah Health Sciences

Related biology news :

1. Gene-environmental interactions and MS progression is focus of new study
2. Manganese in drinking water: Study suggests adverse effects on childrens intellectual abilities
3. Women with diabetes having more C-sections and fetal complications: study
4. Study finds possible persistence switch for tuberculosis
5. New study finds milk drinkers may have a healthy weight advantage
6. Rice study examines how bacteria acquire immunity
7. USF receives NIH grant to study implications of maternal infection as cause of autism
8. Last strongholds for tigers identified in new study
9. VCU study: Team uncovers possible risk gene for schizophrenia
10. LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets
11. OU study on genetics in fruit flies leads to new method for understanding brain function
Post Your Comments:
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
(Date:10/29/2015)... , October 29, 2015 ... biometric authentication company focused on the growing mobile ... wallet announces that StackCommerce, a leading marketplace to ... featuring the Wocket® smart wallet on StackSocial for ... ) ("NXT-ID" or the "Company"), a biometric authentication ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015 Capricor Therapeutics, Inc. ... the discovery, development and commercialization of first-in-class therapeutics, today ... Officer, is scheduled to present at the 2015 Piper ... a.m. EST, at The Lotte New York Palace Hotel ... . --> . ...
(Date:11/24/2015)... INCLINE VILLAGE, Nev. , Nov. 24, 2015  PDL ... John P. McLaughlin , the company,s president and chief ... Piper Jaffray Healthcare Conference next week in New ... and will occur on Tuesday, December 1, 2015 at 9:30 ... and Presentations." Please connect to the website at least 15 ...
(Date:11/24/2015)... ... , ... Whitehouse Laboratories is pleased to announce that it has completed construction ... dedicated to basic USP 61, USP 62 and USP 51 testing specific to raw ... and micro testing performed by one supplier. Management has formally announced that ...
(Date:11/23/2015)... , Nov. 24, 2015 Women with a certain ... exams face a higher risk of lung cancer than men ... next week at the annual meeting of the Radiological Society ... --> --> Lung nodules are ... as solid or subsolid based on their appearance on CT. ...
Breaking Biology Technology: