Navigation Links
Study offers clues to beating hearing loss
Date:3/4/2009

Researchers at the University of Leeds have made a significant step forward in understanding the causes of some forms of deafness.

The Leeds team has discovered that the myosin 7 motor protein - found in the tiny hairs of the inner ear that pick up sound - moves and works in a different way from many other myosins.

Dr Michelle Peckham from the University of Leeds' Faculty of Biological Sciences says: "We're really excited by this discovery as it could lead to new insights into certain forms of deafness. Mutations in this protein have been linked to hearing loss, particularly of the type connected to Usher syndrome, which is a form of degenerative deaf-blindness."

There are around 40 myosin motor proteins in the human body, the most familiar of which is the type of myosin found in skeletal and heart muscle. But all cells have many different kinds of myosin.

Dr Peckham says: "What's exciting about our findings is that we have found that, unlike muscle myosins, which have two heads, myosin 7 only has one. What's more, for the first time we've found how this myosin can be switched on and switched off. When switched off, the tip of its tail curls round and contacts the head, and switched on this contact is broken and the myosin stretches out. This knowledge should help inform any further studies into how a mutation can create problems in hearing."

Follow-up studies could include a more detailed analysis of the role of myosin 7 in Usher syndrome, an inherited genetic condition, which affects hearing, sight and balance. It can vary in its severity; in some cases a child may be born deaf and their sight may deteriorate during childhood, whilst in others the syndrome can go undetected into the teens when hearing and sight usually begins to deteriorate.

There is no cure for Usher syndrome and sufferers are usually offered assistance in managing their disabilities.

Dr Peckham says: "Our studies on how normal myosin 7 works pave the way for understanding how a defective myosin 7 protein in Usher patients results in deafness."


'/>"/>

Contact: Jo Kelly
jokelly@campuspr.co.uk
44-113-258-9880
University of Leeds
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... 18, 2017 MedNet Solutions , ... the entire spectrum of clinical research, is proud ... year for the organization in terms of corporate ... eClinical products and services. The company,s exceptional achievements ... of iMedNet ™ ...
(Date:1/12/2017)... , Jan. 12, 2017  Trovagene, Inc. (NASDAQ: ... DNA (ctDNA) technologies, today announced that it has signed ... and the Middle East ...  This milestone marks the first wave of international distribution ... urine and blood samples. The initial partners ...
(Date:1/12/2017)... , January 12, 2017 A new report by Allied ... that the global biometric technology market is expected to generate revenue of $10.72 billion ... Continue Reading ... Allied Market Research ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... PUNE, India , February 17, 2017 /PRNewswire/ ... research report "Biomarkers Market by Product (Consumables, Service), ... Disorders), Application (Diagnostics Development, Drug Discovery and Development, ... MarketsandMarkets, the market is projected to reach USD ... in 2016, growing at a CAGR of 13.8% ...
(Date:2/16/2017)... , ... February 16, 2017 , ... EIT Digital ... primarily aimed at the agricultural industry. Pilot studies are about to get under way ... IoT, Big Data and 5G innovations. The concept is expected to be transferred eventually ...
(Date:2/16/2017)... Calif. , Feb. 16, 2017  ArmaGen, ... developing groundbreaking therapies to treat severe neurological disorders, ... children treated with AGT-181, the company,s investigational therapy ... (also known as mucopolysaccharidosis type I, or MPS ... 2 proof-of-concept (POC) study, presented today at the ...
(Date:2/16/2017)... -- UCHealth ( Aurora, Colorado ) becomes ... patient management. In addition to optimizing care coordination for ... lung, UCHealth looks to improve provider workflow by decreasing ... Stephanie Brown, RN , Thoracic Nurse Navigator, says, ... Excel spreadsheet, which was extremely arduous and susceptible to ...
Breaking Biology Technology: