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Study of severe asthma using CT scans
Date:6/14/2010

A new study led by University of Leicester researchers at Glenfield Hospital suggests that CT scans may be the way forward for monitoring progression of severe asthma as well as checking how it is responding to treatment.

CT scans, a series of X-ray images of the body, are usually used to detect tumours but the Leicester study, points to their use in asthma. Preliminary results from the study will be showcased at the University of Leicester's Festival of Postgraduate Research on 24 June.

Dr Sumit Gupta, a postgraduate student at the University of Leicester, along with his colleagues at the Institute for Lung Health and Radiology Department at Glenfield Hospital, is investigating the use of Computed Tomography (CT) scanning to assess structural changes in lungs and airways of patients with severe asthma.

Professor Chris Brightling and Dr James Entwisle are supervising this work which is part funded by The Wellcome Trust.

Their findings suggest that CT derived measures of structural changes may potentially be used as a non-invasive 'marker' in asthma to monitor disease progression and response to current and novel treatment.

Dr Gupta said: "Asthma is a major health problem affecting 300 million people worldwide. Approximately half a million people in UK suffer from severe asthma and are, as a consequence, at increased risk of asthma attacks, hospitalization and death and often have severely impaired quality of life. Structural changes that occur in airways of asthmatic individuals remain difficult to quantify and monitor. Computed tomography (CT) scans have now emerged as a non-invasive research tool to assess these airway structural changes. "

Professor Brightling, a Wellcome Trust Senior Clinical Fellow and Honorary Consultant at the Institute for lung Health, who is leading this study, said: "Currently, there is paucity of markers that can be used to monitor asthma progression, response to treatment and
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Contact: Dr Sumit Gupta
sg221@le.ac.uk
01-162-502-589
University of Leicester
Source:Eurekalert

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