Navigation Links
Study of severe asthma using CT scans
Date:6/14/2010

A new study led by University of Leicester researchers at Glenfield Hospital suggests that CT scans may be the way forward for monitoring progression of severe asthma as well as checking how it is responding to treatment.

CT scans, a series of X-ray images of the body, are usually used to detect tumours but the Leicester study, points to their use in asthma. Preliminary results from the study will be showcased at the University of Leicester's Festival of Postgraduate Research on 24 June.

Dr Sumit Gupta, a postgraduate student at the University of Leicester, along with his colleagues at the Institute for Lung Health and Radiology Department at Glenfield Hospital, is investigating the use of Computed Tomography (CT) scanning to assess structural changes in lungs and airways of patients with severe asthma.

Professor Chris Brightling and Dr James Entwisle are supervising this work which is part funded by The Wellcome Trust.

Their findings suggest that CT derived measures of structural changes may potentially be used as a non-invasive 'marker' in asthma to monitor disease progression and response to current and novel treatment.

Dr Gupta said: "Asthma is a major health problem affecting 300 million people worldwide. Approximately half a million people in UK suffer from severe asthma and are, as a consequence, at increased risk of asthma attacks, hospitalization and death and often have severely impaired quality of life. Structural changes that occur in airways of asthmatic individuals remain difficult to quantify and monitor. Computed tomography (CT) scans have now emerged as a non-invasive research tool to assess these airway structural changes. "

Professor Brightling, a Wellcome Trust Senior Clinical Fellow and Honorary Consultant at the Institute for lung Health, who is leading this study, said: "Currently, there is paucity of markers that can be used to monitor asthma progression, response to treatment and to identify patients who will have recurrent asthma attacks and develop persistent airflow obstruction, features particularly relevant to severe asthma."

Dr Gupta and colleagues have demonstrated that CT assessed airway dimensions are associated with worsening of lung functions and airway inflammation. They also observed a reduction in the airway wall thickness along with reduction in asthma attacks amongst severe asthma patients, whose airway inflammation was suppressed by novel therapy, targeting specific type of inflammation. CT scanning therefore may assist in monitoring asthma progression and response to treatment.

Professor Brightling added: "Ability to objectively quantify different structural changes in asthma using CT may assist in differentiating various disease sub-types and help deliver personalised healthcare."

This research work therefore highlights the importance of CT scanning in severe asthma patients and its potential use as a non-invasive 'marker' for monitoring of the disease. This research work was recently showcased in House of Commons during the 'SET for Britain' event. Dr Gupta was the only University of Leicester representative in biomedical sciences at the event.

Dr Gupta is also a radiology speciality trainee at East Midlands Healthcare Workforce Deanery. Fifteen abstracts have been accepted to date for presentation of different aspects of his research work at various international respiratory and radiology meetings. Dr Gupta has five peer reviewed publications in leading medical journals. He was awarded a travel bursary for presenting his research work at European Congress of Radiology 2009 by The Royal College of Radiologists, UK.

The research is being presented to the public at the University of Leicester on June 24. The Festival of Postgraduate Research introduces employers and the public to the next generation of innovators and cutting-edge researchers, and gives postgraduate researchers the opportunity to explain the real world implications of their research to a wide ranging audience. http://www2.le.ac.uk/offices/ssds/sd/pgr/events/fpgr


'/>"/>

Contact: Dr Sumit Gupta
sg221@le.ac.uk
01-162-502-589
University of Leicester
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... MedNet,s significant achievements are the result of the company,s ... iMedNet eClinical , it,s comprehensive, easy-to-use and ... --> Key MedNet growth achievements in ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized ... small to find new ways to ensure data security ... iOS and Android that ties ... biometrics, transforming it into a hardware authorization token. Customer ... swipe their fingerprint on their KodeKey enabled device to ...
(Date:1/11/2016)... Synaptics Incorporated (NASDAQ: SYNA ), the ... its ClearPad ® TouchView ™ 4300 touch ... categories in the 8 th Annual Mobile Excellence ... The Synaptics ® TDDI solution enables faster time-to-market, ... devices, brighter displays and borderless designs. ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... 09, 2016 , ... With a presidential election in November and the future ... bring together over 500 top healthcare leaders for a night and day of debates ... by MBA students of the University of Pennsylvania’s Wharton School, will be held February ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... Tunnell Consulting, ... Based in Paris, he will focus on acquiring new accounts and work closely ... , “Fred brings to our European clients more than 15 years ...
(Date:2/9/2016)... , Feb. 9, 2016 This market ... the current and future prospects of the market in ... report include companies engaged in the manufacture of microbiology ... executive summary with a market snapshot providing the overall ... of this report. This section also provides the overall ...
(Date:2/8/2016)... Feb. 8, 2016 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... ten finalists for clean technology companies in the TSX Venture ... 10 companies listed on the TSX Venture Exchange, in each ... clean technology & life sciences, diversified industries and ... given to return on investment, market cap growth, trading volume ...
Breaking Biology Technology: