Navigation Links
Study of placenta unexpectedly leads to cancer gene

t, researchers set out to find SENP2 target proteins that could be involved in arresting cell growth.

In the journey, they discovered that p53 or proteins that modify p53 activity were harmed by the SENP2 deficiency. The consequence was that p53 could no longer perform its vital job as a tumor suppressor. When p53 is functioning normally, it acts as a crucial guardian of the genome, or a checkpoint, by fixing genetic mistakes as they arise.

But when the p53 molecule is aberrantly regulated, either by an outside virus or an inherited genetic abnormality, the risk of cancer is higher because p53 cannot perform its job.

Researchers also found that SENP2 indirectly regulates p53 activity through another protein called Mdm2, which was already known to be involved in some cancers. In cells lacking SENP2, the Mdm2 becomes trapped in the nucleus, and is unable to halt p53, allowing it to accumulate within the cell. This disruption leads to distinct problems in cell cycle progression and normal gene replication.


Contact: Leslie Orr
University of Rochester Medical Center

Page: 1 2

Related biology news :

1. New study pardons the misunderstood egg
2. Ocean fish farming harms wild fish, study says
3. Proactive care saves lives of seniors, study finds
4. Orangutans spontaneous whistling opens new chapter in study of evolution of speech
5. First-ever socioeconomic study on coral reefs points to challenges of coastal resource management
6. Study reveals effects of unconscious exposure to advertisements
7. Rice University study finds possible clues to epilepsy, autism
8. Researchers study virus with unusual properties
9. Nanotechnology culture war possible, says Yale study
10. Gene therapy corrects sickle cell disease in laboratory study
11. USC researchers head global effort to study genetic risks that contribute to psychiatric diseases
Post Your Comments:
(Date:9/24/2015)... YORK , Sept. 24, 2015  EyeLock LLC, ... be showcasing its award winning and latest technology in ... Anaheim, California . EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:9/10/2015)... 10, 2015 Report Details ... Selling Opportunities and Revenue Prospects to Help You ... biologics, especially new drug classes? Get the latest ... with exclusive market data and industry knowledge, benefitting ... results, opportunities and sales predictions. Visiongain,s new ...
(Date:9/10/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces that the San ... will feature the Wocket® smart wallet for the first ... Touch Of Modern is an online retailer ... its 7.2 million members. Customers are affluent, urban influencers ...
Breaking Biology News(10 mins):
... and their colleagues in Japan are conducting research that may ... necessary step if man someday hopes to build molecular machines ... Dr. Eric Blough, a member of the research ... Biological Sciences, said his group has shown how bionanomotors can ...
... Biologists have known for long that ecology, the interaction ... in forming new species and in modifying living ones. ... The environment defines a template and the process of ... template. Some specialized theory, a few ...
... plant virus lures aphids to infected plants by making the ... they quickly leave for tastier, healthier ones. In the process, ... entomologists. "The virus improves the cues that insects use to ... is already in the plant," said Mark C. Mescher, assistant ...
Cached Biology News:
(Date:10/7/2015)... , Oct. 7, 2015  ChromaDex Corp. (OTCQX: ... nutritional ingredients that creates science-based solutions for dietary ... and pharmaceutical products, today announced that the October ... and Founder, is now available for on-demand viewing ... -->   --> ...
(Date:10/7/2015)... , Oct. 7, 2015   PDI , ... released an infographic that highlights key challenges across various ... appropriate disinfectant for the situation. This tool is part ... hospitals can take to create efficiencies and lower healthcare-associated ... The visual guide emphasizes examples of how to use ...
(Date:10/7/2015)...   VWR (NASDAQ: VWR ), ... services and solutions, announced today that it has ... company that performs high volume purification of selected ... growing laboratory and production chemical manufacturing portfolio to ... Manuel Brocke-Benz , President and CEO ...
(Date:10/7/2015)... ... 07, 2015 , ... Park Systems , world-leader in ... provide a comprehensive overview of the innovations in smart coatings using nanoparticle additives ... This webinar will be given by Professor Roberto Advincula, professor with the Department ...
Breaking Biology Technology:
... Nov. 28 On Monday, December 1, 2008, at,8:30 ... Therapeutics, Inc.,s (CTI) (Nasdaq and MTA: CTIC) management team ... Spectrum Pharmaceuticals,of Irvine, California to jointly market and develop ... Call Numbers, Monday, December 1, ...
... today that it is refocusing all projects and priorities around ... be seen as a,consequence of the negative recommendation of the ... 2008 regarding the,approval of Iclaprim in the U.S. , ... FDA advisory board,s recommendation the Arpida,board intends to put the ...
... house always looking good, without cleaning or giving it ... with paint that can maintain itself and get rid ... process for producing photo-catalytic, self-cleaning coatings has been developed ... and Research), and licensed to Haruna (S) Pte Ltd. ...
Cached Biology Technology: