Navigation Links
Study of microRNA helps NIH scientists unlock secrets of immune cells
Date:6/4/2010

he body of the cell. Not all RNA transcribed from DNA are messenger RNA, however. There are many other forms of RNA that do not code for proteins. MicroRNAs (miRNAs), for example, are small strands of RNA that modulate the production of proteins from messenger RNA, thereby helping to regulate protein levels in the cell. Previous studies have shown that cells are very sensitive to fluctuations in miRNA levels, which require tight control in order to regulate protein activity effectively.

In the current study, the NIH scientists used a new microsequencing technology to comprehensively identify all of the different miRNAs existing in mouse immune cells. In addition to increasing the number of known miRNAs, the scientists also discovered several cellular mechanisms that regulate miRNA abundance. The study found that some miRNA constructs exist in a dormant state within the nucleus until they receive signals from the epigenome to become active. The epigenome regulates transcription and comprises all of the non-genetic material in the nucleus. Other miRNAs, the researchers determined, are not hampered by these epigenetic mechanisms and are controlled simply through transcription. However, for some of these miRNAs, abundance depends upon the amount of target messenger RNA available in the cell.

According to NIAMS Director Stephen I. Katz, M.D., Ph.D., "The data generated from this study represent a useful tool for immunologists and cell biologists to use for future studies on functional aspects of the immune system and basic miRNA biology."


'/>"/>

Contact: Trish Reynolds
reynoldsp2@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... sobering examples of how wildlife loss leads to conflict ... by Wildlife Conservation Society (WCS) Health & Ecosystems: ... calls for an interdisciplinary approach to tackle global biodiversity ... about 15% of the world,s people and provides protein ... It should come as no surprise that today,s unprecedented ...
(Date:7/24/2014)... species for food or commercial food sale, has been ... decline of many species of primates and other mammals. ... half of the species being consumed are birds, particularly ... only the meat made available for sale but the ... hunters and brought to villages for consumption, we noted ...
(Date:7/24/2014)... Angeles, where electric cars ply silent freeways, solar panels ... beneath the earth, from howling winds and from the ... that it is technically and economically feasible to convert ... renewable energy. Published in Energy , the plan ... energy supply in California that could create tens of ...
Breaking Biology News(10 mins):New study draws links between wildlife loss and social conflicts 2Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4
... research shows that we should be looking to the ground, ... its most perilous impact on life on Earth. Scientists ... in the prestigious journal, Nature Geoscience , that show ... in soil. "Soil contains more than twice the ...
... produce the greenhouse gases, methane and carbon dioxide, as ... of a landfill, a process known as ,Phytocapping, could ... to Australian scientists writing in a forthcoming issue of ... Despite legislative pressures to reduce landfill use, in ...
... Bacteria that cause stomach ulcers and cancer could also be ... December issue of the Journal of Medical Microbiology . ... living in the mouths of people who are not ... to over 600 different species of bacteria, some of which ...
Cached Biology News:Global warming is changing organic matter in soil 2Putting a green cap on garbage dumps 2Stomach ulcer bug causes bad breath 2
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
(Date:7/24/2014)... prefer to settle into equilibriuma state of unchanging ... realm of non-equilibrium conditions where new possibilities lie. ... phases, such as temperature fluctuations, freezing and melting, ... their body temperature, airplanes to fly, and the ... But even though these conditions exist naturally and ...
(Date:7/24/2014)... 24, 2014 Your cell phone ... modeling lithium-ion battery storage capacity. , New research ... theoretical model created at Lawrence Livermore National ... predicts how carbon components will perform as electrodes. ... the urgent need for higher-performance batteries. Several key ...
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 Three ... be semi-finalists in Livestrong’s Big C Competition. Out of ... are each headed to the semi-final round. In this ... exclusive three-month accelerator program, complete with mentoring from thought-leaders ... , As part of the angelMD commitment to the ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... 156 Hospitals Validate VISICU,s eICU(R) Program as Solution ... for U.S. Critical Care Crisis, ... likely to die, on average, when treated at hospitals using,the eICU(R) ... http://www.visicu.com/ )., To view the Multimedia News Release, go ...
... clinical trials presented at International ATS Conference ... Data presented today at the,International Conference of ... Inhalation Solution (formoterol fumarate inhalation,solution; FFIS) has ... to the dry powder inhaler (DPI) formulation ...
... Biodel Inc. (Nasdaq:,BIOD) today announced that Alan Krasner, M.D. ... May 27, 2008., "The addition of Dr. Krasner ... regulatory leadership and we expect him to play an,important ... said,Dr. Solomon Steiner, Chief Executive Officer and Chairman of ...
Cached Biology Technology:Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 2Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 3Video: Data From 185,000 ICU Admissions Show Significant Reductions in Mortality: 4Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation 2Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation 3Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation 4Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation 5Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation 6Biodel Inc. Announces Appointment of Alan Krasner, M.D. as Chief Medical Officer 2