"The giant viruses have incredible machinery that seems to be very similar to the machinery that you have in a cell," he said. "They have complexity and we have to explain why."
Part of that complexity includes enzymes involved in translating the genetic code into proteins, he said. Scientists were startled to find these enzymes in viruses, since viruses lack all other known protein-building machinery and must commandeer host proteins to do the work for them.
In the new study, the researchers mapped evolutionary relationships between the protein endowments of hundreds of organisms and used the information to build a new universal tree of life that included viruses. The resulting tree had four clearly differentiated branches, each representing a distinct "supergroup." The giant viruses formed the fourth branch of the tree, distinct from bacteria, archaea and eukarya (plants, animals and all other organisms with nucleated cells).
The researchers discovered that many of the most ancient protein folds those found in most cellular organisms were also present in the giant viruses. This suggests that these viruses appeared quite early in evolution, near the root of the tree of life, Caetano-Anolls said.
The new analysis adds to the evidence that giant viruses were originally much more complex than they are today and experienced a dramatic reduction in their genomes over time, Caetano-Anolls said. This reduction likely explains their eventual adoption of a parasitic lifestyle, he said. He and his colleagues suggest that giant viruses are more like their original ancestors than smaller viruses with pared down genomes.
The researchers
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| Contact: Diana Yates diya@illinois.edu 217-333-5802 University of Illinois at Urbana-Champaign Source:Eurekalert |