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Study may explain exercise-induced fatigue in muscular dystrophies
Date:10/26/2008

called nitric oxide, which stimulates production of a chemical called cGMP that causes smooth muscle around blood vessels to relax thereby increasing blood flow.

This nitric oxide signaling pathway is turned off by phosphodiesterase (PDE), an enzyme that breaks down cGMP. Viagra, a drug designed to increase blood flow, inhibits PDE and prolongs the existence of the cGMP molecules that promote blood vessel dilation.

The researchers showed that Viagra could alleviate fatigue in mice with mislocalized nNOS.

"The mice that have the nNOS mislocalized still have some nitric oxide signaling, but the Viagra enhances that signal by inhibiting PDE and preventing breakdown of cGMP," Campbell said.


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Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
Source:Eurekalert

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