Navigation Links
Study may aid efforts to prevent uncontrolled cell division in cancer
Date:5/28/2009

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.

The researchers show that even though both cell volume and the length of the contractile ring are reduced during successive rounds of embryonic cell division the duration or timing of cell division remains the same. Their study will be published in the May 29 issue of the journal Cell.

"We showed that contractile rings constrict at a constant rate that is proportional to the initial size of the cell, so that rings in larger cells constrict proportionally faster than rings in smaller cells," said Karen Oegema, PhD, associate professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine and the Moores UCSD Cancer Center. "Because of this property, the time required to complete cell division remains the same during embryogenesis, even as cells get smaller."

During their early development, embryos are progressively partitioned into smaller and smaller cells by successive rounds of cell division. The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell. A contractile ring forms a belt around the cell middle; constriction or closure of this ring "tightens the belt," pinching the mother cell into two daughter cells.

In early embryogenesis, cell volume and the length of the contractile ring around the cell middle are reduced at each successive round of cell division. By contrast, the dimension of the chromosomes which carry the genetic material that is segregated to the daughter cells remains constant. The discovery that contractile rings constrict at a constant rate, proportionate to the initial cell size, opens the door to further studies of the mechanism.

"Further studies of the contractile ring could ultimately lead to improved therapies for cancer," said first author Ana Carvalho, PhD. "Understanding the cellular machinery required for cell division may teach us how to prevent the uncontrolled cell division that occurs in cancer."


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related biology news :

1. The coming of biofuels: Study shows reducing gasoline emissions will benefit human health
2. Yale study: Most polluted ecosystems recoverable
3. Study shows CGM devices also benefit people with type 1 diabetes
4. Bolivian rainforest study suggests feeding behavior in monkeys and humans have ancient, shared roots
5. University of Florida study provides insight into evolution of first flowers
6. Study finds genetic links to age of first menstrual period and menopause
7. Study finds link between individual stress and adolescent obesity
8. WWF study says climate change could displace millions in Asias Coral Triangle
9. Study reveals conflict between doctors, midwives over homebirth
10. UNC study identifies genetic cause of most common form of breast cancer
11. Comprehensive genetic study paves way for new blood-pressure medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... -- Trovagene, Inc. (NASDAQ: TROV ), a developer ... it has signed agreements with seven strategic partners across ... Middle East for commercialization of the Trovera™ ... of international distribution agreements for Trovagene,s CLIA based liquid ... The initial partners will introduce Trovagene,s liquid biopsy tests ...
(Date:1/12/2017)... PORTLAND, Oregon and PUNE, India , January 12, 2017 ... Technology Market: Opportunities and Forecasts, 2015 - 2022," projects that the global biometric technology ... CAGR of 19.4% from 2016 to 2022. Continue Reading ... ... ...
(Date:1/11/2017)... N.J. , Jan. 11, 2017  Michael Johnson, co-founder of ... Venture Capital Group, Inc., has been named to the elite "Forbes ... 27,  was one of 600 people in 20 fields nationwide to ... percent of the 15,000 applicants were selected. ... He is currently a PhD candidate at ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... -- AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: AQB), a ... a majority-owned subsidiary of Intrexon Corporation (NYSE: ... of its common shares on the NASDAQ Stock Market ... "AquaBounty,s listing on NASDAQ represents an important milestone for ... U.S. markets as we advance plans for commercial production ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... organization with services spanning the full spectrum of drug and device development, and ... services to pharma/device companies and clinicians, today announced Verified Clinical Trials ...
(Date:1/19/2017)... FRANKLIN LAKES, N.J. , Jan. 18, 2017 BD ... medical technology company, announced today that it will host a live ... 2017, at 1 p.m. (ET). The webcast can ... will be available for replay through Tuesday, January 31, 2017. ... About BD ...
(Date:1/18/2017)... 18, 2017 Applied BioMath ( www.appliedbiomath.com ... drug research and development, today announced that Dr. ... CEO of Applied BioMath, will present at the ... (BAGIM) Meeting on Thursday January 19, 2017 at ... , MA.   Dr. Burke,s talk "Quantitative Modeling and ...
Breaking Biology Technology: