Navigation Links
Study may aid efforts to prevent uncontrolled cell division in cancer
Date:5/28/2009

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.

The researchers show that even though both cell volume and the length of the contractile ring are reduced during successive rounds of embryonic cell division the duration or timing of cell division remains the same. Their study will be published in the May 29 issue of the journal Cell.

"We showed that contractile rings constrict at a constant rate that is proportional to the initial size of the cell, so that rings in larger cells constrict proportionally faster than rings in smaller cells," said Karen Oegema, PhD, associate professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine and the Moores UCSD Cancer Center. "Because of this property, the time required to complete cell division remains the same during embryogenesis, even as cells get smaller."

During their early development, embryos are progressively partitioned into smaller and smaller cells by successive rounds of cell division. The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell. A contractile ring forms a belt around the cell middle; constriction or closure of this ring "tightens the belt," pinching the mother cell into two daughter cells.

In early embryogenesis, cell volume and the length of the contractile ring around the cell middle are reduced at each successive round of cell division. By contrast, the dimension of the chromosomes which carry the genetic material that is segregated to the daughter cells remains constant. The discovery that contractile rings constrict at a constant rate, proportionate to the initial cell size, opens the door to further studies of the mechanism.

"Further studies of the contractile ring could ultimately lead to improved therapies for cancer," said first author Ana Carvalho, PhD. "Understanding the cellular machinery required for cell division may teach us how to prevent the uncontrolled cell division that occurs in cancer."


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related biology news :

1. The coming of biofuels: Study shows reducing gasoline emissions will benefit human health
2. Yale study: Most polluted ecosystems recoverable
3. Study shows CGM devices also benefit people with type 1 diabetes
4. Bolivian rainforest study suggests feeding behavior in monkeys and humans have ancient, shared roots
5. University of Florida study provides insight into evolution of first flowers
6. Study finds genetic links to age of first menstrual period and menopause
7. Study finds link between individual stress and adolescent obesity
8. WWF study says climate change could displace millions in Asias Coral Triangle
9. Study reveals conflict between doctors, midwives over homebirth
10. UNC study identifies genetic cause of most common form of breast cancer
11. Comprehensive genetic study paves way for new blood-pressure medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... (PRWEB) , ... April 20, 2017 , ... Parallel6™ ... clinical trials worldwide, announced today that they were named one of the 2017 ... covers the latest developments in the pharmaceutical industry. , “We take pride in honoring ...
(Date:4/20/2017)... Israel , April 20, 2017  BrainStorm Cell Therapeutics ... technologies for neurodegenerative diseases, announced today that Chaim Lebovits ... Regenerative Medicine,s (ARM) 5 th Annual Cell & Gene ... EDT in Boston . In ... Officer & Chief Operating Officer, will participate in a panel ...
(Date:4/19/2017)... Yorba Linda, Ca (PRWEB) , ... April 18, 2017 , ... ... highlight new technological advances. This webinar, which is part of the Protein and ... NxT Flow Cytometer and outline where this technology fits in current and future applications. ...
(Date:4/19/2017)... (PRWEB) , ... April 19, 2017 , ... Nobilis ... Disorder , Company Seeks to Leverage Clinical Data in its Upcoming Post Traumatic Stress ... registration of an 81 patient clinical trial assessing efficacy of its NBTX-001, a xenon-based ...
Breaking Biology Technology: