Navigation Links
Study maps human metabolism in health and disease
Date:3/3/2013

Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle.

The international team of researchers say their study published in Nature Biotechnology provides the best model yet to explain why individuals react differently to environmental factors such as diet or medication.

"This research is the second important stage of our understanding of the human genome," said study author Professor Pedro Mendes, from The University of Manchester's School of Computer Science. "If the sequencing of the human genome provided us with a list of the biological parts then our study explains how these parts operate within different individuals.

"The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require is likely to affect them according to their specific genetic characteristics. The model takes us an important step closer to what is termed 'personalised medicine', where treatments are tailored according to the patient's genetic information."

The research, which involved scientists from Manchester, Cambridge, Edinburgh, Reykjavik, San Diego, Berlin and others, mapped 65 different human cell types and half of the 2,600 enzymes that are known drug targets in order to produce the network model.

Co-author Douglas Kell, Chief Executive of Biotechnology and Biological Sciences Research Council (BBSRC) and Professor of Bioanalytical Science at the Manchester Institute of Biotechnology, said: "To understand the behaviour of a system one must have a model of it. By converting our biological knowledge into a mathematical model format, this work provides a freely accessible tool that will offer an in-depth understanding of human metabolism and its key role in many major human diseases.

"This study off
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-771-788-1563
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU-Boulder study
2. Study provides insights into plant evolution
3. New study reveals how sensitive US East Coast regions may be to ocean acidification
4. CETS offers new method to help simplify the study of brain pathologies
5. New study could explain why some people get zits and others dont
6. Global tipping point not backed by science: Study
7. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
8. Wayne State study shows airborne dust in urban areas impacts lead levels in children
9. Georgia Physicians Study Published in The Journal of Urology
10. New study shows continued decline in the last remaining stronghold for leatherback sea turtles
11. Study finds maize in diets of people in coastal Peru dates to 5,000 years ago
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
(Date:12/3/2014)... 2014   Marvin Test Solutions , a ... for military, aerospace, and manufacturing organizations, today announced ... TS-900 PXI semiconductor test platform . The ... systems to customers at a fraction of the ... ATE. "Our semiconductor customers asked ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... do not immediately engage in a race against time to ... survive the global warming and acidification predicted for later this ... scientists from around the world in a major new study ... that the public understands that the lack of sustainability in ...
... HOBOKEN, N.J. Katherine Freed, undergraduate at Stevens Institute ... Undergraduate Poster Contest in Las Vegas in November 2007. ... win this ISPE award. Her winning poster, Impedance Mammography, ... Senior Design team at Stevens., In April 2007, the ...
... -- At its core, healthy neurological function hinges on the ... Figuring out how the synapse traffics this information -- ... function of the healthy and diseased brain. Now, ... in New York City has spotted a crucial new piece ...
Cached Biology News:Major study concludes that global warming is killing off coral 2Katherine Freed wins first place at the International ISPE Undergraduate Poster Contest 2A key enzyme helps keep the synapse on track 2A key enzyme helps keep the synapse on track 3
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ) ... Innovations in Smart Fabrics (Technical Insights)" report ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service titled ... assessment on technological advancements and market for Smart ... 1. The Smart Fabrics market is expected to ...
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... dental biomaterial market will grow moderately through 2023 as ... and growing awareness of dental biomaterials all spur procedure ... such as China and ... bring dental procedures within reach for a larger proportion ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... PharmaTech (Cayman) Inc. (NYSE: WX ... pharmaceutical, biotechnology, and medical device industries, with operations in China ... the third quarter of 2011. Highlights ... Year to $104.0 Million Manufacturing Services Net Revenues ...
... CENTENNIAL, Colo., Nov. 10, 2011 LABS, Inc., a ... of expertise in regulated testing for human organs, cells, ... that it ranked #52 among Colorado,s top private companies, ... 250 Private Companies list. The Top 250 ...
... 10, 2011 Theravalues, a Japan based ... positively on the prevention of heart failure and its ... human clinical trial started with the registration in July ... Kyoto Medical Center and University of Shizuoka, Japan, the ...
Cached Biology Technology:WuXi PharmaTech Announces Third-Quarter 2011 Results 2WuXi PharmaTech Announces Third-Quarter 2011 Results 3WuXi PharmaTech Announces Third-Quarter 2011 Results 4WuXi PharmaTech Announces Third-Quarter 2011 Results 5WuXi PharmaTech Announces Third-Quarter 2011 Results 6WuXi PharmaTech Announces Third-Quarter 2011 Results 7WuXi PharmaTech Announces Third-Quarter 2011 Results 8WuXi PharmaTech Announces Third-Quarter 2011 Results 9WuXi PharmaTech Announces Third-Quarter 2011 Results 10WuXi PharmaTech Announces Third-Quarter 2011 Results 11WuXi PharmaTech Announces Third-Quarter 2011 Results 12WuXi PharmaTech Announces Third-Quarter 2011 Results 13WuXi PharmaTech Announces Third-Quarter 2011 Results 14WuXi PharmaTech Announces Third-Quarter 2011 Results 15WuXi PharmaTech Announces Third-Quarter 2011 Results 16WuXi PharmaTech Announces Third-Quarter 2011 Results 17WuXi PharmaTech Announces Third-Quarter 2011 Results 18LABS, Inc. Among Colorado's Top Private Companies 2Theravalues Confirms Beneficial Effects of Theracurmin™ on Diastolic Function in Hypertensive Patients 2
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
anti-achaete...
... Super-Sensitive, Super-Dark, Super-Small! ... with the ChemiDoc-It Imaging System. High-sensitivity ... produces low-background noise and wide dynamic ... a short exposure time. The light-tight ...
... Based Oligonucleotide) Genome Set and MEEBO (Mouse ... contain a collection of open source oligo ... allowing interrogation of thousands of genes. Developed ... University and UCSF, the sets enable the ...
Biology Products: