Navigation Links
Study looks at possible link to hyper-excitability factors in epilepsy, autism and more
Date:2/14/2012

A UT Dallas study is revealing new information about a key protein's role in the development of epilepsy, autism and other neurological disorders. This work could one day lead to new treatments for the conditions.

Dr. Marco Atzori, associate professor in The University of Texas at Dallas' School of Behavioral and Brain Sciences (BBS), has worked with senior neuroscience student Francisco Garcia on a series of papers that outline their findings about interleukin 6 (IL-6) and hyper-excitability. An article on the project is slated for publication in Biological Psychiatry later this year.

Scientists know that stress elevates the levels of pro-inflammatory cytokines (signaling molecules used in intercellular communication) and promotes hyper-excitable conditions within the central nervous system. This hyper-excitability is thought to be a factor in epilepsy, autism and anxiety disorders.

Garcia and Atzori hypothesized that the protein IL-6 acutely and directly induces hyper-excitability by altering the balance between excitation and inhibition within synaptic communication. In other words, IL-6 is not just present when hyper-excitability occurs in the nervous system. It may actually cause it in some circumstances, Garcia said.

The UT Dallas research team administered IL-6 to rat brain tissue and monitored its synaptic excitability. The brain tissue exhibited higher than normal excitability in their synapses, a symptom that may lead to misfiring of signals in epilepsy and other conditions.

The researchers then injected sgp130 -a novel drug that acts as an IL-6 blocker- into the laboratory animals' brains. The substance limited excitability and appeared to prevent the conditions that lead to related neurological and psychiatric disorders, Garcia said.

"This finding has the potential to lead to eventual new treatments for epilepsy, anxiety disorders or autism," Garcia said.

The next stage of this re
'/>"/>

Contact: Emily Martinez
emily.martinez@utdallas.edu
214-905-3049
University of Texas at Dallas
Source:Eurekalert

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... WASH. July 11, 2014 Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/11/2014)... evidence has demonstrated that transplantation of mesenchymal stem cells ... or mouse models of Alzheimer,s disease (AD) and improve ... ischemia. Few studies are reported on the therapeutic effect ... AD and on the effect on oxidative injury and ... Yan and her team, School of Life Sciences, Tsinghua ...
(Date:7/11/2014)... is evidence that under the normal circumstances, ... development, maintain neuronal environment, and exhibit therapeutic ... neurodegenerative disease. Previous studies have found that ... after chemical induction have reduced viability, which ... Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2
... from Kent State University and the University of ... species Cycloprosopon dobrogea in eastern Romania. Previously unexamined, ... more than 150 million years ago during the ... crabs helps determine various aspects of biodiversity and ...
... St. Paul, Minn. (October 17, 2007) Deadlines ... reservations are quickly approaching for the 2007 National ... Symposium will be held December 12-14, 2007 at ... The 2007 symposium, organized by The American ...
... imagist and researcher at Harvard University,s Initiative in ... the 2007 Lennart Nilsson Award. Frankel was sited ... art and crystal-clear scientific illustrations both fascinating ... community alike. The Lennart Nilsson Award is ...
Cached Biology News:Deadlines for 2007 National Soybean Rust Symposium fast approaching 2Lennart Nilsson Award 2007 2
(Date:7/10/2014)... 2014 Robert Harman, DVM, Founder and CEO ... proud to announce the relaunch of his highly informative blog, ... series called “ What are Stem Cells ?” Dr. ... straightforward foundation in the basics of stem cell therapy so ... right type of treatment when considering regenerative medicine. , A ...
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
(Date:7/10/2014)... Hall effect in bilayer graphene and shown that this ... electric field. , The fractional quantum Hall effect, ... are exposed to large magnetic fields, is a striking ... behave as a single system. However, while the basic ... of this collective behavior remain not well understood, in ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... Ill., Jan. 5, 2012 Baxter International Inc. ... in a Phase I clinical trial of its ... form of a full-length recombinant factor VIII (rFVIII) ... [Antihemophilic Factor (Recombinant) Plasma/Albumin-Free Method] full-length rFVIII molecule ...
...  ZyGEM Corp. Ltd., a developer and marketer of ... other nucleic acids, and the US Army Medical ... the signing of a Cooperative Research and Development ... processing solutions for biothreat agents.  The two organizations ...
... Spine, LLC, a medical device company focused on developing ... degenerative disc disease, today announced a 46% sales increase ... the revenue improvement, RSB Spine Chief Executive Officer John ... rewarding considering the overall spine market contraction in 2011, ...
Cached Biology Technology:Baxter Initiates Phase I Clinical Trial of Longer-acting Recombinant FVIII Treatment for Hemophilia A 2Baxter Initiates Phase I Clinical Trial of Longer-acting Recombinant FVIII Treatment for Hemophilia A 3Baxter Initiates Phase I Clinical Trial of Longer-acting Recombinant FVIII Treatment for Hemophilia A 4Baxter Initiates Phase I Clinical Trial of Longer-acting Recombinant FVIII Treatment for Hemophilia A 5ZyGEM and USAMRIID Sign CRADA for Development of Simplified Sample Processing Solutions for Biothreat Agents 2ZyGEM and USAMRIID Sign CRADA for Development of Simplified Sample Processing Solutions for Biothreat Agents 3
PGC-1 (H-300)...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Anti-human CD48/BLAST-1, clone MEM102, Monoclonal Antibody...
Affinity Purified Anti-Human NP-1...
Biology Products: