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Study looks at possible link to hyper-excitability factors in epilepsy, autism and more
Date:2/14/2012

A UT Dallas study is revealing new information about a key protein's role in the development of epilepsy, autism and other neurological disorders. This work could one day lead to new treatments for the conditions.

Dr. Marco Atzori, associate professor in The University of Texas at Dallas' School of Behavioral and Brain Sciences (BBS), has worked with senior neuroscience student Francisco Garcia on a series of papers that outline their findings about interleukin 6 (IL-6) and hyper-excitability. An article on the project is slated for publication in Biological Psychiatry later this year.

Scientists know that stress elevates the levels of pro-inflammatory cytokines (signaling molecules used in intercellular communication) and promotes hyper-excitable conditions within the central nervous system. This hyper-excitability is thought to be a factor in epilepsy, autism and anxiety disorders.

Garcia and Atzori hypothesized that the protein IL-6 acutely and directly induces hyper-excitability by altering the balance between excitation and inhibition within synaptic communication. In other words, IL-6 is not just present when hyper-excitability occurs in the nervous system. It may actually cause it in some circumstances, Garcia said.

The UT Dallas research team administered IL-6 to rat brain tissue and monitored its synaptic excitability. The brain tissue exhibited higher than normal excitability in their synapses, a symptom that may lead to misfiring of signals in epilepsy and other conditions.

The researchers then injected sgp130 -a novel drug that acts as an IL-6 blocker- into the laboratory animals' brains. The substance limited excitability and appeared to prevent the conditions that lead to related neurological and psychiatric disorders, Garcia said.

"This finding has the potential to lead to eventual new treatments for epilepsy, anxiety disorders or autism," Garcia said.

The next stage of this re
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Contact: Emily Martinez
emily.martinez@utdallas.edu
214-905-3049
University of Texas at Dallas
Source:Eurekalert

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