Navigation Links
Study locates cholesterol genes; finds surprises about good, bad cholesterol
Date:1/13/2008

ANN ARBOR, Mich.---An international study of 20,000 people found seven new genes that influence blood cholesterol levels, a major factor in heart disease, and confirmed 11 other genes previously thought to influence cholesterol.

The international study led by researchers from the University of Michigan School of Public Health set out to identify or confirm genetic variants that influence lipid levels, and secondly, to see if those variants were linked to the decreased or increased risk of heart disease. The findings will be published online in the journal Nature Genetics on Jan. 13.

The results may lead the medical community to rethink the role of HDL (good cholesterol) and LDL (bad cholesterol) in heart disease, said Goncalo Abecasis, associate professor in the U-M School of Public Health. Abecasis co-directed the study with Karen Mohlke, assistant professor of genetics at the University of North Carolina at Chapel Hill School of Medicine.

"It was surprising that while genetic variants that increase your bad cholesterol are also associated with increased risk of heart disease, we did not find that variants influencing your good cholesterol were associated with decreased risk of coronary artery disease. Perhaps that result will lead us to reexamine the roles of good and bad cholesterol in susceptibility to heart disease," Abecasis said.

Coronary artery disease, a condition where plaque accumulates on the walls of coronary arteries, is the most common type of heart disease and a leading cause of death in industrialized countries. The type and amount of cholesterol and other lipids in the bloodstream contribute to the risk of coronary artery disease, which can cause heart attack, stroke, angina and other heart conditions. Both genetic and environmental factors influence a person's cholesterol and blood lipid levels.

"Finding new gene regions associated with cholesterol levels may bring us one step closer
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study suggests genetic connection between short stature and arthritis
2. Radioactive understudy may aid medical imaging, drug development
3. Surprise -- cholesterol may actually pose benefits, study shows
4. Hybridization partially restores vision in cavefish, NYU study finds
5. Study of sugars on cell surface identifies key factor in flu infection
6. Human hormone blocker found to help prevent obesity and diabetes: study
7. UVa biomedical engineering study shows magnetic field can reduce swelling
8. First-ever study to link increased mortality specifically to carbon dioxide emissions
9. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
10. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
11. Deep-sea species loss could lead to oceans collapse, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... of the International Society for Sexually Transmitted Disease Research ... City, Canada. The world,s foremost conference in the ... from every continent to discuss the most recent developments ... emerging threats in bacterial STDs; major intervention programs for ...
... University of Georgia researcher has invented a new ... clothing, face masks, paper towelsand yes, even diapers, ... germ-free. The simple and inexpensive anti-microbial technology ... can be applied during the manufacturing process or ...
... are developing new technologies that combine a laser ... particles such as bacteria, viruses and DNA for ... to food safety. The technologies could bring ... or miniature instruments that perform measurements normally requiring ...
Cached Biology News:New UGA technology makes textiles permanently germ-free; targets health care-associated infections 2New UGA technology makes textiles permanently germ-free; targets health care-associated infections 3Laser, electric fields combined for new 'lab-on-chip' technologies 2Laser, electric fields combined for new 'lab-on-chip' technologies 3
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 ... into law H.R. 83, the Omnibus and Continuing ... first time, made hydrocephalus a condition eligible to ... Programs (CDMRP) administered by the Department of Defense ... with its allies on Capitol Hill, is celebrating ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , Healthcare and ... free download , digs deep into this vibrant market, ... sector today. One area where Algeria ... a homegrown pharmaceutical manufacturing base, even if the government,s ambitious ... off. A cursory comparison with neighboring Morocco ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... In a video interview, new CEO,Andrew Witty comments on ... strategic vision for the business., The ... diversified global business - Deliver more products of value ... and vodcast are available now on, http://www.cantos.com . It,s free ...
... 23 Duska Therapeutics,Inc. (OTC Bulletin Board: DSKA) ... a synopsis of a proposed Phase 3 clinical ... Food and Drug Administration,s (the,"FDA") Division of Cardiovascular ... with the FDA, including a face-to-face,meeting held on ...
... Next generation design reduces the amount of retraction needed for surgical ... ... July 23 Pioneer Surgical Technology,today announces the market availability of ... optimize,anterior cervical fusion procedures while addressing the clinical needs of,anterior cervical ...
Cached Biology Technology:Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 2Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 3Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment 4Pioneer(R) Surgical Technology, Inc. Announces the Market Launch of the SlimFuse(TM) Anterior Cervical Plate System 2
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Proliferin (C-14)...
... the computing power of your ValveBank system! ... sequences with a Macintosh computer using graphic ... to disk, print out program listings, then ... in one simple step., EasyCode is used ...
... series of Class II Biological Safety ... certification to the world's highest safety ... the cabinets cannot be adjusted out ... low noise and arm rest ensure ...
Biology Products: