Navigation Links
Study links nicotine with breast cancer growth and spread
Date:10/14/2008

PHILADELPHIA A study published in Cancer Research, a journal of the American Association for Cancer Research, suggests a possible role for nicotine in breast tumor development and metastases.

The study, conducted by researchers at the Beth Israel Deaconess Medical Center, is among the first to explore the effects of nicotine on mammary cells.

"Although numerous studies indicate the role of nicotine exposure in tumor promotion, little is known about the effect of nicotine on breast tumor development, especially on the metastatic process of breast cancer," said lead author Chang Yan Chen, Ph.D., M.D., at Beth Israel Deaconess Medical Center.

Through a series of in vitro tests Chen and her team of researchers determined that breast epithelial-like MCF10A cells and cancerous MCF7 cells both express several subunits of nAChR (nicotine receptor), that when bound, initiate a signaling process, potentially increasing cell growth and migration.

"The best known role of nAChR is in the nerve system," Chen said. "Although cells from various tissue origins express different subunits of nAChR, we know very little about the functions of nAChR in non-neuronal cells and tissues, in particular in mammary cells."

"We were able to determine that mammary cells express different subunits of nAChR and that nicotine, possibly through perturbing cell cycle checkpoints, potentiates tumorigenesis in mammary cancer-prone or cancer cells," Chen said.

In vivo studies confirmed these findings. When injected into the tail of a mouse the cancerous MCF7 cells migrated to the lungs.

From in vivo and in vitro studies, it indicates that nicotine is not a conventional carcinogen, but rather it combines with other yet to be determined factors to enable tumorigenesis.

"In vitro and in vivo tests showed that no metastasis occurs when the administration of nicotine alone," said Chen. "At this point we can only suggest
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... PRINCETON, N.J. , Aug. 18, 2015 ... be a key contributor to the Submission ... hosted by IRISS, a non-profit forum. Dedicated to ... IRISS provides a neutral platform for industry, ... to share information and work towards a ...
(Date:8/12/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is proud to announce that iMedNet ... platform, has led the way to significant and unprecedented ...   Q2 2015 and Q1 2015 were, respectively, the ... sold in the company,s 15 year history.  In addition, ...
(Date:8/12/2015)... JOSE, Calif. , Aug. 12, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... recently announced Match-in-Sensor solution, have officially been named ... Alliance. As part of the certification, Synaptics, Natural ... FIDO 1.0 Universal Authentication Framework (UAF) standard and ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3MedNet Solutions Experiences Explosive Corporate Growth 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... 1 issue of G&D, Dr. Christopher Fasano (Memorial Sloan-Kettering ... the effective generation of neural stem cells outside of ... that the polycomb group protein, Bmi-1, maintains forebrain neural ... embryonic forebrain neural progenitor cells increases stem cell self-renewal ...
... commercialization office of Queen,s University, has been awarded ... establishment of a National Centre of Excellence for ... The first entity of its kind ... Canada,s leading Green Chemistry researchers, industry partners, and ...
... CAMBRIDGE, Mass.--Lip reading is a critical means of communication for ... (for example, p and b) can be nearly impossible to ... waves into vibrations that can be felt by the skin, ... that can,t be gleaned from lip reading. Researchers in ...
Cached Biology News:Queen's receives $9.1 million to establish National Center of Excellence in green chemistry 2Queen's receives $9.1 million to establish National Center of Excellence in green chemistry 3MIT: Using touch to help deaf people 2
(Date:9/3/2015)... 3, 2015  StemProtein LLC, a leading manufacturer ... of Stemedica Cell Technologies Inc., announced today that ... CEO of StemProtein. Silberg will help advance the ... Stem Cell Factors (SCFs), a significant consumer opportunity. ... pharmaceutical and biopharmaceutical industries with substantial executive level ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... release its non-invasive hydration monitoring wearable early 2016. , The device, called ... using proprietary optical and electrical sensing technology. These sensors track trending interstitial ...
(Date:9/2/2015)... , Sept. 2, 2015 Research ... the addition of Jain PharmaBiotech,s new report ... to their offering. An ... and biotechnology industries is anticipated. Nanotechnology will ... development - from formulations for optimal delivery ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... ) has announced the addition of Jain PharmaBiotech,s ... Markets and Companies" to their offering. ... markets based on technologies and applications. The report ... basis for estimation of markets. Technologies include array ...
Breaking Biology Technology:StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2
... , ... DC Protein Assay reagents contain both detergent and base,which are required for cell lysis ... used for tissue cells; dry cells; protein precipitates from,heat, acid, or acetone treatment; or ... , , ...
... Slyker, B Gillece-Castro, M Nguyen, L Sapp, MG Brubacher, and WB , ... Association of Biomolecular Resource , Facilities (ABRF) , ... , Abstract , ... analysis. The quality and value of the information obtained from ...
... Roche Discovery Welwyn, 40 Broadwater Road, Welwyn , Garden ... Syngenta, Jealotts Hill International Research Centre, Bracknell, Berkshire, , ... Abstract , I ... running 2-D SDS-PAGE slab gels with preparative protein loads. The Dodeca ...
Cached Biology Technology:Total Cellular Protein Determination Using the DC Protein Assay 2Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A 2Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A 3Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A 4Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A 5Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A 6Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 2Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 3Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 4Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 5
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 25 tests...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: