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Study links molecule to muscle maturation, muscle cancer
Date:12/30/2008

cells, or lowered the level of the NF-B protein, the cells' growth rate dropped two fold, and they began taking on the appearance of mature muscle cells. The modified cells also formed significantly smaller tumors when transplanted into an animal model than did typical rhabdomyosarcoma cells.

"High levels of the protein silence miR-29, which blocks differentiation, causing muscle cells to remain immature. If we can restore the levels of miR-29 in patients," Guttridge says, "it might provide a new therapy for this childhood cancer and perhaps other muscle diseases."


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Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert  

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