Navigation Links
Study links intestinal bacteria to rheumatoid arthritis
Date:11/5/2013

ink between the abundance of P. copri and the onset of rheumatoid arthritis," Dr. Littman says. "We are developing new tools that will hopefully allow us to ask if this is indeed the case."

The new findings, reported today in the open-access journal eLife, were inspired by previous research in Dr. Littman's laboratory, collaborating with Harvard Medical School investigators, using mice genetically predisposed to rheumatoid arthritis, which resist the disease if kept in sterile environments, but show signs of joint inflammation when exposed to otherwise benign gut bacteria known as segmented filamentous bacteria.

Rheumatoid arthritis, an autoimmune disease that attacks joint tissue and causes painful, often debilitating stiffness and swelling, affects 1.3 million Americans. It strikes twice as many women as men and its cause remains unknown although genetic and environmental factors are thought to play a role.

The human gut is home to hundreds of species of beneficial bacteria, including P. copri, which ferment undigested carbohydrates to fuel the body and keep harmful bacteria in check. The immune system, primed to attack foreign microbes, possesses the extraordinary ability to distinguish benign or beneficial bacteria from pathogenic bacteria. This ability may be compromised, however, when the gut's microbial ecosystem is thrown off balance.

"Expansion of P. copri in the intestinal microbiota exacerbates colonic inflammation in mouse models and may offer insight into the systemic autoimmune response seen in rheumatoid arthritis," says Randy S. Longman, MD, PhD, a post-doctoral fellow in Dr. Littman's laboratory and a gastroenterologist at Weill-Cornell, and an author on the new study. Exactly how this expansion relates to disease remains unclear even in animal models, he says.

Why P. copri growth seems to take off in newly diagnosed patients with rheumatoid arthritis is also unclear,
'/>"/>

Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Holograms offer hope in fight against malaria, study suggests
2. Acupuncture effects on neuropathic pain: A study on signal pathways
3. Genetic study proves Israels wild boars originated in Europe
4. Dolphin genetic study provides revelations
5. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
6. Genetic rarity rules in wild guppy population, study finds
7. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
8. Mechanisms of wound healing are clarified in MBL zebrafish study
9. New study suggests coral reefs may be able to adapt to moderate climate change
10. Study challenges soil testing for potassium and the fertilizer value of potassium chloride
11. Study of Brazilian Amazon shows 50,000 km of road was built in just 3 years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
(Date:4/13/2015)... NEW YORK , April 13, 2015 /PRNewswire/ ... study by TechSci Research, "Global Biometrics Market Forecast & ... to register a CAGR of around 14% till ... various governments for large scale implementation and review ... technology and launch of new products with greater ...
(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... at UT Southwestern Medical Center say there are at ... colon cancer, far more than scientists previously thought. ... 2011 Cancer Research (Priority Reports), researchers are suggesting a ... and pathways simultaneously. Current cancer treatments target just one ...
... Boston, MA Using nanotechnology to engineer sensors ... Women,s Hospital (BWH) have developed a platform technology for ... in both science and medicine by providing the ability ... and develop effective therapeutics. These findings are published in ...
... amount of pollution that is showing up in data from ... red butterfly in the skies over southern part of the ... image of the pollution from agricultural fires in central Africa ... the period from July 7 to 12, 2011. It was ...
Cached Biology News:Researchers provide means of monitoring cellular interactions 2NASA's Aura satellite measures pollution 'butterfly' from fires in central Africa 2
(Date:5/29/2015)... SPRING, Md. and RESEARCH TRIANGLE PARK, ... Corporation (NASDAQ: UTHR ) announced today that Roger ... Therapeutics, will provide an overview and update on the company,s ... New York City . The presentation ... Thursday, June 4, 2015, at 11:00 AM Eastern Time, and ...
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Technologies, Markets, and Companies" to their ... This report deals with therapeutic ... at improving patient care by monitoring drug ...
(Date:5/28/2015)... , May 27, 2015 Research ... of Jain PharmaBiotech,s new report "Cell Therapy ... offering. This report describes and evaluates ... started to play an important role in the ... replacing the old fashioned bone marrow transplants. Role ...
(Date:5/28/2015)... May 28, 2015 DryLet, LLC ... in applications such as animal waste reduction, bioremediation, ... reduction in wastewater treatment plants and restaurant kitchen ... World Pork Expo, June 3-5 in Des Moines, ... in a Wall Street Journal article because of ...
Breaking Biology Technology:Global Therapeutic Drug Monitoring Market 2015-2024 2Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2DryLet to Showcase Patented ManureMagicâ„¢ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2
... the enzyme market is significant and estimated at €3.4 billion ... sold in many different industry segments. These segments are Detergents, Food, ... ... (PRWEB) July 8, 2008 -- According to CBDM.T®, The market and ...
... PRINCETON, N.J., July 7 Medarex, Inc.,(Nasdaq: MEDX ... to,listen to a live webcast of its 2008 R&D ... 2008 at 8:00 a.m. Eastern Time and is expected ... will,provide an overview of the company,s strategy, progress and ...
... DIEGO, July 7 AMN Healthcare Services,Inc. (NYSE: ... United,States, will host its quarterly conference call to discuss ... p.m. Eastern Time. The,company expects to issue an earnings ... 4:00 p.m. Eastern Time., A live webcast of ...
Cached Biology Technology:CBDM.T, The Market and Business Intelligence Company Reviews The Enzyme Market 2CBDM.T, The Market and Business Intelligence Company Reviews The Enzyme Market 3Medarex Announces July 10 Live Webcast of R&D Day Event 2AMN Healthcare Services to Host 2008 Second Quarter Earnings Conference Call on Wednesday, August 6, 2008 2
Determin interaction of your protein with Echelons lipids...
Anti-Human Complement Component C4c, IgY fraction (Polyclonal) (chicken IgY)...
... tubes are used to store 2.0 ml ... uniform walls for uniform heat transfer and ... caps. The O-rings are made of polyethylene ... from -55 to 150 degrees C. Supplied ...
... protein A media yield highly purified ... to analysis of other immunoglobulin classes, ... purification. Protein A binds to the ... from mammalian species. This ready-to-use, bottled ...
Biology Products: