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Study led by NUS researchers proves the existence of 3 overstretched DNA structures
Date:2/28/2013

t: NUS)

Biological Implications and Potential Applications

As forces over a wide range are present in the DNA of cells, the researchers' findings provide new perspectives of possible force-dependent regulations of critical biological processes, such as DNA damage repair and gene transcriptions.

In addition, as many recently developed DNA devices are based on thermo-mechanical properties of various DNA structural motifs, these findings may also have potential applications in designing new DNA devices for the future.

The Next Step

To further their research, Assoc Prof Yan and his team will study the physiological functions of the three overstretched DNA structures, and investigate the presence of any new DNA structures under other mechanical constraints.


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Contact: Sarah LOKE
scilwms@nus.edu.sg
65-660-12844
National University of Singapore
Source:Eurekalert  

Page: 1 2

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