Navigation Links
Study indicates vitamin A plays key role in the human body
Date:3/17/2011

Grand Rapids, Mich. (March 17, 2011) In a recently-published study mapping the structure and function of the so-called "orphan" nuclear receptor TR4, Van Andel Research Institute (VARI) investigators suggest that Vitamin A may play a more direct role than was previously known in certain physiological functions including sperm cell formation and the development of the central nervous system.

Scientists had previously determined that Vitamin A derivatives such as retinal and the retinoic acids are involved in physiological functions in the human body. But there has been little direct evidence to show that Vitamin A, or retinol, the most common dietary form of the vitamin and the parental compound of the retinoid group, is directly involved in nuclear receptor signaling pathways a process which activates genes in the human body.

"Our study found that Vitamin A itself is active for activating nuclear receptor TR4," said VARI Research Scientist Edward Zhou, Ph.D. "Because TR4 plays roles in sperm cell production, lipid and lipoprotein regulation, the development of the central nervous system, and the regulation of hemoglobin production in the embryo, we can imagine that Vitamin A may play more important roles in human physiology than was previously believed."

The study, published in the Journal of Biological Chemistry, was named by the journal as a "Paper of the Week," indicating that the study is in the top 1 percent of published papers in terms of significance and overall importance. About 50 to 100 such studies are selected from the more than 6,600 published by the journal each year.

Nuclear receptors activate genes in important biological processes in the human body. Orphan nuclear receptors are a group of nuclear receptors whose ligands, or the substance to which receptors bind, have not yet been identified, and whose physiological functions have not been very well investigated.

"Recent evidence has show
'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... Calif. , Aug. 6, 2015  Today, ... will visit Crossmatch ™ to learn firsthand ... and protect data. Crossmatch is a world leader ... technologies and expertise are helping federal agencies and ... and security.   "The vast majority ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors market ... in applications, penetration into newer sectors, and development of ... global biosensors space has seen the entry of multiple ... so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... Analysis of the Global Biosensors Market ( ...
(Date:7/31/2015)... de julio de 2015 BGI llevará a cabo ... del 22 al 25 de octubre de 2015, en ... conferencia celebra su décimo aniversario este año. Desde su ... de las reuniones anuales más influyentes del mundo en ... las conferencias científicas más dinámicas, entusiastas y amenas. ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3
... protect nerves are the likely origin of the Devil Facial ... population, an international team of scientists has discovered. ... affects only Tasmanian devils and was first reported in 1996. ... The disease is characterised by large tumours, mostly on the ...
... FL Scientists from The Scripps Research Institute have ... infectious protein devoid of DNA or RNA that can ... The study from Scripps Florida in Jupiter ... at the protein level and, through natural selection, these ...
... in the remains of long-dead plants, animals, or humans allows ... studies of this kind on ancestral members of our own ... ancient DNA from modern-day human DNA contamination. Now, research by ... Leipzig, published online on December 31st in Current Biology ...
Cached Biology News:Nervous culprit found for Tassie devil facial tumor disease 2Scripps Florida scientists show 'lifeless' prions capable of evolutionary change and adaptation 2Scripps Florida scientists show 'lifeless' prions capable of evolutionary change and adaptation 3Scripps Florida scientists show 'lifeless' prions capable of evolutionary change and adaptation 4Using modern sequencing techniques to study ancient modern humans 2
(Date:8/31/2015)... SAN DIEGO , Aug. 31, 2015 ... drug development company announces that the Company,s lead antibody, ... subject of five separate presentations during the upcoming World ... Hawaii September 2-5, 2015. Researchers from the ... (MSK) will present results on the use of MabVax,s ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Mexico Biomedical Sensors market is estimated at $0.20 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ) has announced the ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Middle East & Africa Biomedical Sensors ... a CAGR of 3.26% over the period 2014-2020 ... are adaptable to the genetic formulation of each individual. ...
(Date:8/31/2015)... Portage Biotech Inc. ("Portage" or "the Company") (OTC Market: ... that its wholly owned subsidiary, Portage Pharmaceuticals Ltd. (PPL) ... Investigational New Drug (IND) application for the topical treatment ... a study in a rat model of dry eye ... and a more rapid onset of action than 0.1% ...
Breaking Biology Technology:MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4Mexico Biomedical Sensors Market Report 2015-2020 2Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 3
... CALGARY, Nov. 29 /PRNewswire-FirstCall/ - Oncolytics Biotech ... Coffey, Chief,Scientific Officer of Oncolytics, is scheduled ... 2007 entitled "Large Scale Production Process for,the ... Informa Life,Sciences, 3rd Annual Vaccine Production Conference ...
... properties of a commonly used blue dye could revolutionise ... Advanced Materials. , Scientists have demonstrated that they can ... Phthalocyanine, or MPc, with the use of magnetism. ... researchers claim that the ability to control the magnetic ...
... Calif., Nov. 28 Bionovo, Inc.,(Nasdaq: BNVI ), a ... in the areas of women,s health and cancer, is scheduled ... Conference., The presentation by Tom Chesterman, SVP and CFO ... at 1:30 p.m. local time at the,Millennium Broadway Hotel in ...
Cached Biology Technology:Oncolytics Biotech Inc. to Present at Annual Vaccine Production Conference 2Blue dye could hold the key to super processing power 2Blue dye could hold the key to super processing power 3
... Timp-4 has been reported in heart ... fibroblasts in cell culture conditions. ... TPA stimulates production of TIMP-4 in ... protein levels produced often require concentration ...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Anti-MMP-13 Collagenase-3, amino terminal end of active enzyme; rabbit host...
...
Biology Products: