Navigation Links
Study indicates that induced labor may not lower risk of infection or respiratory problems in newborns

DALLAS (Feb. 9, 2012) In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting , in Dallas, Texas, researchers will report findings that suggest that induction of labor in patients who suffer a rupture of membranes between the 34th and 37th week of gestation (before the onset of labor) does not reduce the risk of infection or respiratory problems in the newborn.

"Our research indicates that in patients who underwent close monitoring, known as expectant management, versus those whose labor was induced, there was no difference in the risk for infection in the newborn, breathing problems in the newborn or caesarean section rates," said David van der Ham, MD, with the Maastricht University Medical Center, Obstetrics & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands, and one of the study's authors. "Due to these findings, we suggested expectant management as opposed to induced labor when possible."

For the study, entitled Induction of Labor Versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes Between 34 and 37 Weeks the PPROMEXIL-2 trial, van der Ham and his colleagues observed 536 women from January 2007 until September 2009, and 195 women from December 2009 until January 2011. The study was performed in a multicenter setting within the Dutch obstetric research consortium, in which 60 hospitals in the Netherlands collaborated. After 24 hours of ruptured membranes, patients were allocated to either immediate delivery or expectant management until 37 weeks of gestational age.

The results indicate that: expectant management prolonged pregnancy for 3.5 days; the risk for neonatal sepsis (infection of the newborn) overall was low (3.6%) and did not differ between treatment strategies; the risk for respiratory distress syndrome (breathing problems of the newborn) did not differ between treatment strategies; and caesarean section rates were equal in both treatment strategies. Combined with results of all previous published trials there was no difference in the identified risks.

In addition to van der Ham, the study was conducted by Jantien van der Heijden and Hans van Beek, VieCuri Medical Center, Obstetrics & Gynecology, Venlo, Netherlands; Brent Opmeer, Academic Medical Center, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, Netherlands; Christine Willekes and Jan Nijhuis, Maastricht University Medical Center, Obstetrics & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands; Twan Mulder, Maastricht University Medical Center, Pediatrics, Maastricht, Netherlands; Rob Moonen, Atrium Medical Center, Pediatrics, Heerlen, Netherlands; Marielle van Pampus, University Medical Center Groningen, Obstetrics and Gynecology, Groningen, Netherlands; Mariet Groenewout, University Medical Center Groningen, Obstetrics & Gynecology, Groningen, Netherlands; Gerald Mantel, Isala klinieken, Obstetrics & Gynecology, Zwolle, Netherlands; Anneke Kwee, Dutch consortium AMPHIA trial, Netherlands; Hajo Wildschut, Erasmus Medical Center, Obstetrics & Gynecology, Rotterdam, Netherlands; Bettina Akerboom, Albert Schweitzer Hospital, Obstetrics and Gynecology, Dordrecht, Netherlands; and Ben Mol, Academic Medical Center, Department of Obstetrics and Gynaecology, Amsterdam, Netherlands.


Contact: Vicki Bendure
Society for Maternal-Fetal Medicine

Related biology news :

1. NIH study links high levels of cadmium, lead in blood to pregnancy delay
2. New study sheds light on genetics of rice metabolism
3. Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach
4. A zap of cold plasma reduces harmful bacteria on raw chicken in Drexel study
5. Heat and cold damage corals in their own ways, Scripps study shows
6. Satellite study reveals critical habitat and corridors for worlds rarest gorilla
7. Body clock receptor linked to diabetes in new genetic study
8. Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
9. Study pinpoints genetic variation that raises a risk linked to bisphosphonates
10. UMass Amherst ecologists among the first to record and study deep-sea fish noises
11. Coastal storms have long-reaching effects, study says
Post Your Comments:
(Date:11/18/2015)... Nov. 18, 2015  As new scientific discoveries deepen ... and other healthcare providers face challenges in better using ... patients. In addition, as more children continue to survive ... adulthood and old age. John M. Maris, ... Hospital of Philadelphia (CHOP) . --> ...
(Date:11/17/2015)... PARIS , November 17, 2015 ... November 2015.   --> Paris from ... --> DERMALOG, the biometrics innovation leader, has invented the ... and fingerprints on the same scanning surface. Until now two ... fingerprints. Now one scanner can capture both on the same ...
(Date:11/17/2015)... 17, 2015  Vigilant Solutions announces today that Mr. ... of Directors. --> --> ... from the partnership at TPG Capital, one of the ... $140 Billion in revenue.  He founded and led TPG,s ... TPG companies, from 1997 to 2013.  In his first ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... cat and human plaque and pave the way for more ... problems in cats     --> ... most commonly diagnosed health problems in cats, yet relatively little ... now. Two collaborative studies have been conducted by researchers from ...
(Date:11/25/2015)... -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Neurocrine Biosciences, will be presenting at the 27th Annual ... . .   Listeners ... prior to the presentation to download or install any ... available on the website approximately one hour after the ...
(Date:11/25/2015)... ... November 25, 2015 , ... A long-standing partnership between ... (OPBAP) has been formalized with the signing of a Memorandum of Understanding. , ... leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, at ...
(Date:11/25/2015)... The Global Genomics Industry ... and in-depth study on the current state of ... ) , The report provides ... classifications, applications and industry chain structure. The Genomics ... including development trends, competitive landscape analysis, and key ...
Breaking Biology Technology: