Navigation Links
Study in roundworm chromosomes may offer new clues to tumor genome development
Date:4/21/2011

CHAPEL HILL, N.C. A study of DNA rearrangements in roundworm chromosomes may offer new insight into large-scale genome duplications that occur in developing tumors.

A report of the research led by University of North Carolina at Chapel Hill School of Medicine scientists was published in the April 22 online edition of the journal Science. The study focused on telomeres, a region of repetitive DNA sequence that protects the ends of chromosomes from deterioration or from fusing with other chromosomes.

In many organisms, including humans, chromosome ends are capped by simple repetitive sequences that are replenished by addition of new telomere repeats by the enzyme telomerase. Since most human cells don't produce enough of the enzyme, they are unable to maintain the repeat DNA sequences that cap their chromosome ends.

"Once telomere repeat sequences erode completely, a chromosome end will 'uncap' and fuse with another uncapped chromosome end," said senior study author Shawn Ahmed, PhD, associate professor of genetics and a member of the UNC Lineberger Comprehensive Cancer Center. "Thus, the chromosome aberrations that we isolated from telomerase mutants in the common roundworm C. elegans were end-to-end chromosome fusions."

Ahmed points out that during development of many forms of cancer, chromosome ends erode and 'uncap', and many end-to-end chromosome fusions occur. These fusions create genome rearrangements that may contribute to tumor development.

The new findings tested predictions of a long-standing model developed in the 1940s by geneticist Barbara McClintock, 1983 Nobel Laurate in Physiology or Medicine. This model, termed the breakage-fusion-bridge cycle, suggested that DNA duplications at fused chromosome ends should be perfect inverted duplications that are created by fusion and then breakage of a fused chromosome during the process of cell division, mitosis.

"Surprisingly, many of the duplic
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... SM announced today its completion of a Good ... current U.S. Food and Drug Administration (FDA) regulations. This ... smart phone application trials utilizing the highest principles for ... determined to improve global healthcare access, quality, and delivery ...
(Date:12/11/2014)... and Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... the addition of the "Biometrics Market in the ... One major trend emerging in this market is ... is important to upgrade biometric solutions to the latest ...
(Date:12/10/2014)... 2014  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... that crystals form the basis for the penetrating icy blue glare ... solar energy technology? Crystals are at the heart of diodes. ... manufactured to form alloys, such as indium gallium nitride or InGaN. ... in the visible range, and of laser diodes (LDs) in the ...
... Ore. -- (Oct. 25, 2013) -- Twenty grams of essential amino ... weeks after knee-replacement surgeries helped 16 patients, mean age 69, recover ... ingesting a placebo. The approach -- detailed in a paper ... the Journal of Clinical Investigation -- could spell relief ...
... the region? A recent study, published in the open access ... obtain empirical data on the activity and distribution of the ... of Fiji and examine its association with the invasive creeping ... the invasive creeping daisy could in fact have a positive ...
Cached Biology News:ASU, Georgia Tech create breakthrough for solar cell efficiency 2Oregon researchers say supplement cuts muscle loss in knee replacements 2Oregon researchers say supplement cuts muscle loss in knee replacements 3Oregon researchers say supplement cuts muscle loss in knee replacements 4Angel or demon: Can a potentially invasive plant bring a positive influence to a region? 2
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. ... marketer of proprietary clinical grade hypothermic storage and ... products for cells and tissues  ("BioLife" or the "Company"), ... of Stockholders on May 4, 2015 (the "Annual Meeting"). ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Technologies, Inc. announced this week that it has finalized ... in Avegno for exclusive distribution rights of the AcceleDent™ ... AcceleDent™ System is currently being sold outside the USA ... The lightweight appliance, used to speed up the rate of orthodontic ...
... New York, November 21, 2011 New Report ... to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures ...   Published by  GBI Research . ... to 2017 - Glaucoma and Cataract Surgery Devices, Minimally ...
... 21, 2011 The report " ... Myeloid Leukemia) Pipeline Assessment & Global Market Forecast (2010 ... major market drivers, restraints, and opportunities in North America, ... tables and in-depth TOC on Leukemia Therapeutics Market (Acute/Chronic ...
Cached Biology Technology:OrthoAccel® Technologies, Inc. Announces Definitive Distribution Agreement in Italy 2OrthoAccel® Technologies, Inc. Announces Definitive Distribution Agreement in Italy 3ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 2ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 3ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 4MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 2MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 3
Physical Form: saline suspension with ethanol Particle Dim: mean particle size 50 μm Matrix: HyperD F. Useful for the removal of detergents from protein samples....
... The Caliper Sciclone ALH 3000 workstation ... diagnostic applications, from Genomic and Proteomic Sample ... Assays. The modular design of the ... options and accessories to perfectly meet the ...
General description: MaxiSorp TM surface is ideal for arraying molecules with mixed hydrophilic/hydrophobic domains such as proteins ID clarifier: Maxisorp(tm) with lid...
... Workstation from Caliper represents a revolutionary breakthrough ... first time the ability to generate real-time ... changing conditions. In addition, each channel ... to changes in temperature, and offers its ...
Biology Products: