Navigation Links
Study in mice yields Angelman advance
Date:2/13/2013

h a history

Although the researchers were surprised by the details they discovered about how Arc hinders the signaling process, they didn't come to the insight with complete naivete.

In other work, Marshall had been studying CN2097, designed by co-author Mark Spaller of Dartmouth College (Spaller synthesized it during earlier tenures at Wayne State University and Brown). The compound, which binds to PSD-95 was predicted to protect neurons under conditions of stroke and in disease states such as multiple sclerosis. With co-senior author Dennis Goebel of Wayne State, Marshall and Spaller found this to be the case. During the course of those studies the Marshall group learned that CN2097 enhanced the action of brain-derived neurotrophic factor (BDNF) which is known to be critically involved in long-term potentiation (LTP), a phenomenon believed by many neuroscientists to underlie learning.

Then, when University of North Carolina professor and former Brown postdoc Ben Philpot, now a leading expert on Angelman syndrome, returned to campus in 2008 to speak about Angelman syndrome, he showed how LTP is notably lacking in mice with the condition. After discussions with Philpot, Marshall and his group decided to test whether CN2097 might restore LTP in Angelman mice.

Early on, Marshall said, the team figured the defect in LTP in Angelman mice effect had to do with BDNF signaling.

"We started studying BDNF signaling in the Angelman syndrome mouse and discovered the signaling was defective, so that really was the breakthrough," he said. "It was completely unexpected. It's a new way of thinking about this disease."

That led to the set of experiments now reported in PLOS Biology, in which the group found that CN2097 essentially protects PSD-95 from interference by Arc, helping to restore BDNF signaling and the formation of stronger synapses. In electrophysiological tests on hippocampal tissue of healthy and Angelman mic
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Southwest regional warming likely cause of pinyon pine cone decline, says CU study
2. Nature Methods study: Using light to control cell clustering
3. New study finds neither HFCS nor table sugar increases liver fat under real world conditions
4. Study prompts rethink of how ovaries develop
5. First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment
6. Studying bed bug actions for new management tactics
7. Study identifies liver gene that regulates cholesterol and fat blood levels
8. Study shows disease spread in ladybirds with sexually transmitted disease
9. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
10. Study of a rare disease making people look like a woman but having male genitals under study
11. Study finds potential to match tumors with known cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study in mice yields Angelman advance
(Date:8/31/2014)... Nature Climate Change , suggests that if current trends ... the global targets for total greenhouse gas (GHG) emissions in ... think carefully about the food we choose and its environmental ... just one of a number of actions that need to ... is enough food for all. , As populations rise ...
(Date:8/31/2014)... French . ... the prestigious Nature Neuroscience journal by, Sylvain Williams, ... Douglas Mental Health University Institute and McGill University, opens the ... mechanisms controlling memory as well of the role of an ... subiculum. , In 2009, they developed a unique approach ...
(Date:8/29/2014)... SAN ANTONIO (Aug. 29, 2014) Scientists at the ... the School of Medicine at the UT Health Science ... longevity in the tissues of the longest-lived rodent, the ... factor in the cells of naked mole rats protects ... disposer for damaged and obsolete proteins. , The factor ...
Breaking Biology News(10 mins):Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2Factor in naked mole rat's cells enhances protein integrity 2
... agricultural ecosystems near Montreal, a new tool that ... wide range of ecological services has been developed ... Geography, Elena Bennett of the McGill School of ... Centre at Stockholm University. Environmental management typically focuses ...
... is available in German . Halle ... around 115,000 years ago, there were significant climate fluctuations. ... the Eemian Interglacial to the Weichselian Glacial was marked ... at least two warming events. This is the finding ...
... The 2010 American Society for Microbiology (ASM) ... presented to John J. Tudor, Ph.D., St. Joseph,s ... years of teaching. This award recognizes an educator ... Tudor received his Ph.D. from the University ...
Cached Biology News:Seeing the hidden services of nature 2Were short warm periods typical for transitions between interglacial and glacial epochs? 2American Society for Microbiology honors John J. Tudor 2
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... Pittcon is pleased to announce that the ... Horiba Scientific, have organized a session on nanotechnology for ... , Asia’s largest analytical and scientific instruments show, will ... , The four speakers in this U.S. symposium, ... to Single Cells” will present their use of nanotechnology ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Livermore Team Awarded for Hydrogen Production Research 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... journal BioMedical Engineering OnLine refutes claims that portable music ... , Howard Bassen, a researcher with the U.S. Food ... team that measured the magnetic fields produced by four ... iPod with video, and an iPod nano and iPod ...
... Medical,Innovations, Inc. (Amex: IMA ), a leading ... consumer and professional markets, announced,today that it will ... and Medical Device Conference being held,February 5 through ... New York City. Ron,Zwanziger, Chief Executive Officer, and ...
... Promotions Support Fund,s Goal of Finding a Cure ... Pfizer Animal Health and the National,Thoroughbred Racing Association ... through the NTRA Charities - Barbaro Memorial Fund. ... Fund across the horse,industry and encourage further support ...
Cached Biology Technology:New research shows that iPods do not interfere with cardiac pacemakers 2Inverness Medical Innovations to Participate at 2008 Merrill Lynch Global Pharmaceutical, Biotechnology and Medical Device Conference on February 5, 2008 2Pfizer Animal Health and NTRA Charities Team Up to Benefit the Barbaro Memorial Fund 2
... range of next-generation features into a small-footprint ... for flexible laboratory solutions. It puts every ... dilution, dispensing, and integrations into a ... flexible as it is efficient and economical. ...
... mini incubation trays are disposable ... screen antigens that have been ... tray has eight 10.5 cm ... accommodate strips cut from blotted ...
... The GenomeLab GeXP Genetic Analysis System ... scalable, multiplexed PCR*. The systems patented ... standard multiplexed PCR analysis to just a ... GeXP delivers more genes per reaction and ...
... Chemicon Detergent-OUT SDS Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... Med columns are suitable for removing ...
Biology Products: