Navigation Links
Study in mice yields Angelman advance
Date:2/13/2013

h a history

Although the researchers were surprised by the details they discovered about how Arc hinders the signaling process, they didn't come to the insight with complete naivete.

In other work, Marshall had been studying CN2097, designed by co-author Mark Spaller of Dartmouth College (Spaller synthesized it during earlier tenures at Wayne State University and Brown). The compound, which binds to PSD-95 was predicted to protect neurons under conditions of stroke and in disease states such as multiple sclerosis. With co-senior author Dennis Goebel of Wayne State, Marshall and Spaller found this to be the case. During the course of those studies the Marshall group learned that CN2097 enhanced the action of brain-derived neurotrophic factor (BDNF) which is known to be critically involved in long-term potentiation (LTP), a phenomenon believed by many neuroscientists to underlie learning.

Then, when University of North Carolina professor and former Brown postdoc Ben Philpot, now a leading expert on Angelman syndrome, returned to campus in 2008 to speak about Angelman syndrome, he showed how LTP is notably lacking in mice with the condition. After discussions with Philpot, Marshall and his group decided to test whether CN2097 might restore LTP in Angelman mice.

Early on, Marshall said, the team figured the defect in LTP in Angelman mice effect had to do with BDNF signaling.

"We started studying BDNF signaling in the Angelman syndrome mouse and discovered the signaling was defective, so that really was the breakthrough," he said. "It was completely unexpected. It's a new way of thinking about this disease."

That led to the set of experiments now reported in PLOS Biology, in which the group found that CN2097 essentially protects PSD-95 from interference by Arc, helping to restore BDNF signaling and the formation of stronger synapses. In electrophysiological tests on hippocampal tissue of healthy and Angelman mic
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Southwest regional warming likely cause of pinyon pine cone decline, says CU study
2. Nature Methods study: Using light to control cell clustering
3. New study finds neither HFCS nor table sugar increases liver fat under real world conditions
4. Study prompts rethink of how ovaries develop
5. First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment
6. Studying bed bug actions for new management tactics
7. Study identifies liver gene that regulates cholesterol and fat blood levels
8. Study shows disease spread in ladybirds with sexually transmitted disease
9. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
10. Study of a rare disease making people look like a woman but having male genitals under study
11. Study finds potential to match tumors with known cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study in mice yields Angelman advance
(Date:7/31/2014)... German . ... to a sponge that soaks up liquids. Hence, these ... greenhouse gases. However, loading of many MOFs is inhibited ... now report in Nature Communications that the ... This can be prevented by water-free synthesis and storing ...
(Date:7/31/2014)... has been made to help better identify and treat those ... narrowing and enlarging of medium sized arteries in the body, ... organs causing damage. In a new report appearing in August ... scientists provide evidence that that FMD may not be limited ... a connection to abnormalities of bones and joints, as well ...
(Date:7/31/2014)... A Florida State University researcher found that bacteria in ... components of the oil released during the Deepwater Horizon ... the most toxic contaminants. , In two new studies ... Mason found a species of bacteria called Colwellia ... ethylbenzene and xylene compounds that were released as part ...
Breaking Biology News(10 mins):Free pores for molecule transport 2Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2
... class of drugs used by millions worldwide to effectively ... impact in Multiple Sclerosis (MS) patients treated with high ... the Montreal Neurological Institute (MNI), McGill University, demonstrates that ... in the central nervous system. The findings, published in ...
... a young person who dies suddenly should always be ... identify if they too are at risk of sudden ... European Society of Human Genetics today (Tuesday 26 May). ... fellow at the Department of Cardiogenetics, Academic Medical Centre, ...
... have been able to identify genetic factors that influence the ... Ms Lisette Stolk, a researcher from Erasmus MC, Rotterdam, ... of Human Genetics today ( Monday 25 May) that a ... eventually help to improve the clinical treatment of infertile women. ...
Cached Biology News:One size does not fit all 2Comprehensive cardiogenetic testing for families of sudden unexplained death victims can save lives 2Identification of genetic variants affecting age at menopause could help improve fertility treatment 2
(Date:7/31/2014)... Calif. (PRWEB) July 31, 2014 Held ... diagnosed patients with an overview of the disease and ... of drug side effects, as well as updates on ... grateful to Dr. Sandy Srinivas for organizing this educational ... of kidney cancer. “Sandy and her colleagues have put ...
(Date:7/31/2014)... The global market for molecular diagnostics is ... to a new study by Grand View Research, Inc. ... subsequent introduction of advanced cancer diagnostic technologies are expected ... next six years. Moreover, the growing global base of ... with disease triggering lifestyle habits such as smoking and ...
(Date:7/31/2014)... IL (PRWEB) July 31, 2014 ... of automation across the U.S., increasing unemployment, depressing ... class. It is a Catch 22—we need ... but this means fewer jobs,” says economist and ... just-released Pollina Corporate Top 10 Pro-Business States for ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... and collaboration company, is proud to announce the ... LMS complements Adobe Connect’s elearning tools to quickly ... delivers content with training tools for desktop and ... with LMS is the perfect online training solution, ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2
... to IT Nirvana, and I like it. , ,OK, maybe thats ... the VP of IT at Rayovac , it sounds like ... fighting for respect. They get invited to the table when its ... They arent nearly deaf from the constant ringing of alarm bells. ...
... Rayovac signs $1.2 billion deal for United Industries , ... Rayovac Corp. has negotiated a contract to purchase St. ... and common stock, with the deal expected to close in ... the lawn and garden product market, obtaining United brands such ...
... of digital convergence on Thursday at the Consumer Electronics Show ... service. , ,Designed as part of the companys plan ... digital video recording and Internet service in a set-top box. ... connection. , ,In his keynote address, SBC chairman Edward Whitacre ...
Cached Biology Technology:Is Rayovac IT Nirvana? An exclusive interview with Rick Dempsey, VP of IT 2Is Rayovac IT Nirvana? An exclusive interview with Rick Dempsey, VP of IT 3Is Rayovac IT Nirvana? An exclusive interview with Rick Dempsey, VP of IT 4Tech Digest: Rayovac, Inacom, TomoTherapy, Regal-Beloit, Modine 2SBC blends TV, video, music and the Internet in a new media box 2
...
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
... The dsRNA Marker consists of ten double-stranded ... 300, 400, 500 and 1,000 base pairs. ... marker for determinating sizes of double-stranded RNAs. ... the dsRNA Marker is adjusted to approximately ...
... raised against a partial recombinant ... HD (NP_002102, 81 a.a. ... protein with GST tag. ... NM_002111 Protein ...
Biology Products: