Navigation Links
Study identifies promising target for AIDS vaccine
Date:3/31/2011

BOSTON--A section of the AIDS virus's protein envelope once considered an improbable target for a vaccine now appears to be one of the most promising, new research by Dana-Farber Cancer Institute scientists indicates.

The section, a twisting strand of protein known as the V3 loop, is an attractive vaccine target because immune system antibodies aimed at the loop may offer protection against multiple genetic subtypes of HIV-1, the virus that causes AIDS. This is a key prerequisite of any AIDS vaccine because the viruses mutate rapidly and by now comprise millions of different strains that are grouped into different genetic subtypes, or "clades." The researchers' findings are published online in the Public Library of Science journal PLoS One.

In the study, investigators injected a monoclonal antibody -- a preparation of millions of identical antibodies that fight viral infection -- into Asian monkeys known as macaques. The antibody came from a person infected with a specific clade of HIV-1. The macaques were then exposed to virus of a different clade. Investigators knew the antibody would latch onto a portion of the virus's V3 loop, potentially barring the virus from invading nearby cells, but they didn't know whether it would prevent infection from a separate subtype of the virus.

The results were striking: All of the treated monkeys were protected from infection by the monkey form of HIV-1, known as SHIV. Monkeys exposed to the virus without receiving the monoclonal antibody, by contrast, became heavily infected.

"This is the first time a monoclonal antibody made against an AIDS virus of one clade has provided complete protection against an AIDS virus of a different clade in animal models," said the study's senior author, Ruth Ruprecht, MD, PhD, of Dana-Farber. "Previous studies have shown that such neutralizing antibodies can protect macaques from infection within one clade; but as more clades of the AIDS virus evo
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. European-wide study confirms benefits of D-penicillamine and trientine for Wilson disease
2. UC Riverside researcher receives $9 million USDA grant to study potato and tomato disease
3. New study shows you can have your candy and eat it too -- without adverse health effects
4. Study: Emissions trading doesnt cause pollution hot spots
5. Butterfly study reveals traits and genes associated with establishment of new populations
6. Study shows hunger hitting closer to home
7. Most states unclear about storage, use of babies blood samples, new study finds
8. GPS study shows wolves more reliant on a cattle diet
9. Russian boreal forests undergoing vegetation change, study shows
10. Spicing up your love life possible, study finds
11. Study finds weight training safe for pregnant women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... -- What do mollusks, starfish, and corals have ... they are all calcifiersorganisms that use calcium from ... shells for stability and protection. , The July ... by the Marine Biological Laboratory, addresses the challenges ... worldwide. , As atmospheric carbon dioxide rises, the ...
(Date:7/23/2014)... of getting tangled and forming knots. Scientists study these ... disentangle them (e.g. useful for gene sequencing techniques). Cristian ... (SISSA) in Trieste and his team have been carrying ... their dynamics. In their latest paper, just published in ... Marco Di Stefano, first author and PhD student at ...
(Date:7/23/2014)... exists for Alzheimer,s disease, the devastating neurological disease ... are now reporting new progress on a set ... shows promise as a potential oral therapy for ... of Medicinal Chemistry . , Carlo Ballatore, Kurt ... healthy brain, the protein known as tau binds ...
Breaking Biology News(10 mins):Calcification in changing oceans explored in special issue of The Biological Bulletin 2
... nowhere is this math more evident than in vertebrates, which ... many species do not. Snakes, of course, have no digits, ... a good handle on how these developmental changes are orchestrated ... on birds: Which digits are they: a thumb with index ...
... from the University of California, Davis, and the University of ... the energy-generating structures within cells, divide. The work, which could ... was published today (Sept. 2) in the journal Science ... Jodi Nunnari, professor and chair of molecular cell biology at ...
... two images taken simultaneously with different Envisat sensors of Hurricane Irene, ... black and white image is from Envisat,s radar, covering the coastal ... provides an unusual view of a hurricane as it shows the ... of the image, a dark spot can be seen where the ...
Cached Biology News:New insight in how cells' powerhouse divides 2
(Date:7/23/2014)... Shimadzu Scientific Instruments has launched ... system developed jointly with Ajinomoto Co. Inc. Offering ... 38 amino acids in nine minutes, drastically enhancing ... analysis utilizing a fast application-specific column and an ... results even under conditions with difficult samples that ...
(Date:7/23/2014)... ANTONIO , 23 de julio de 2014 ... (ADBI o la Compañía) ha anunciado hoy una ... Akron (ABIA o el Instituto), para ... ADBI, un dispositivo de terapia de señal bioeléctrica ... El Instituto, que tiene una importante ...
(Date:7/23/2014)... 2014 DuPont Pioneer announced today that ... president of Agricultural Biotechnology (ABT), effective July 21, 2014. ... most recently as president, chief executive officer and board ... in the seed and crop protection industry to this ... Schickler , president of DuPont Pioneer. “I am looking ...
(Date:7/23/2014)... Shire plc (LSE: SHP, ... biopharmaceutical company, and ArmaGen, a US privately held ... collaboration agreement for AGT-182, an investigational enzyme replacement ... the central nervous system (CNS) and somatic manifestations ... collaboration strengthens Shire,s rare disease pipeline of innovative ...
Breaking Biology Technology:Shimadzu's New UF-Amino Station Provides High-Speed, Multi-Component Analysis of Amino Acids in Food & Beverage and Pharmaceutical Testing 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5
... an improved governance structure, the benefits of nanotechnology may ... not trust the cutting-edge technology, says David Rejeski, director ... on Thursday, April 24, before the Senate subcommittee on ... dark horse in nanotechnologys future, states Rejeski in his ...
... Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) today announced that ... on Wednesday, April 30,2008, after the market closes. The ... 2:00 p.m. PT, which will be open to the ... company will review,the financial results and discuss other business ...
... 23 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) ... group at St. James,s University Hospital in Leeds,U.K. ... in the May 1, 2008,online issue of The ... Human Dendritic Cells to Promote Innate Antitumor Immunity.", ...
Cached Biology Technology:Improved governance needed to realize nanotech's benefits 2Sangamo BioSciences Announces First Quarter Conference Call and Webcast 2Sangamo BioSciences Announces First Quarter Conference Call and Webcast 3Oncolytics Biotech Inc. Announces Journal of Immunology Publication on Reovirus Activation of Dendritic Cells 2
... a highly purified preparation of the catalytic ... which recognizes the identical cleavage site as ... enzymatic activity (1). Novagen&'s enzyme is produced ... the highest activity available, and is qualified ...
Strip Removal Tool 25/Box...
... The Beacon 2000 Fluorescence Polarization System ... research and assay development. Standard Beacon ... 2000 System uses a quartz-halogen lamp ... of 360-700 nm. It accommodates all ...
... Effectively condenses and traps a wide variety of ... pump oil. Easy-to-use glass condensation flask (GCF400) allows ... contained jar for easy draining. Rapid cooling time ... glass flask for quick solvent changes ...
Biology Products: