Navigation Links
Study identifies novel genomic changes in the most common type of lung cancer
Date:7/9/2014

omes. However, for the time being, stopping smoking or never starting remain the most reliable ways to reduce the number of deaths due to lung cancer."

In the group's initial scan of tumor samples, researchers identified gene mutations that would increase RTK/RAS/RAF pathway activity in 62 percent of the samples. The affected genes are oncogenes, or genes that have the potential to cause cancer when mutated or expressed at high levels. Consequently, these tumor samples were classified as oncogene-positive.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome. In doing so, they detected amplification of two oncogenes, ERBB2 and MET, which are part of the RTK/RAS/RAF pathway. Gene amplification usually leads to increased expression of the encoded protein in cells.

Now that these amplifications have been identified, clinicians may be able to treat patients whose tumors have specific gene changes with drugs currently available or under development.

"It is quite striking that we have now identified an actionable mutation in over 75 percent of patients with lung adenocarcinoma, a significant improvement from a decade ago," said Matthew Meyerson, M.D., Ph.D., Harvard Medical School, Dana-Farber Cancer Institute, The Broad Institute, and one of the lead investigators on the project.

Additional analysis identified other genes that may play important roles in lung cancer development. Mutations in one of these genes, NF1, had previously been reported in lung cancer; NF1 is a known tumor suppressor gene that regulates the RTK/RAS/RAF pathway. Mutations in NF1 also put the pathway into overdrive. Another mutated gene, RIT1, is also part of the RTK/RAS/RAF pathway, and this is the first study to associate mutation of this gene with lung cancer.

"This most recent TCGA stu
'/>"/>

Contact: Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bee foraging chronically impaired by pesticide exposure: Study
2. New study finds that Adélie penguin population is on the rise
3. Sunshine vitamin ups bowel cancer survival odds, study finds
4. More California gas stations can provide H2 than previously thought, Sandia study says
5. HIV study leads to insights into deadly infection
6. Study reveals fungus in yogurt outbreak poses a threat to consumers
7. New study of largely unstudied mesophotic coral reef geology
8. CWRU and collaborators receive $12.6 million NIH grant to study genetics of Alzheimers
9. Study reveals strong links between Antarctic climate, food web
10. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
11. Doctoral students to study biology, mechanics connection under NIH grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... type and number of connections in transcription factor networks ... in a study published in PLOS Computational Biology ... assortativity signature contributes to a network,s resilience against mutations. ... out-out assortativity of TFN models has a greater effect ... types of assortativity," said Dov A. Pechenick, PhD, lead ...
(Date:8/29/2014)... twist them, fold them: modern materials that are light, ... as artificial skin or electronic paper. , Making such ... but a new way of working with copper nanowires ... , Previous success in the field of ultra-lightweight ... precious gold and silver nanowires. , By turning ...
(Date:8/28/2014)... that an expansion of marine protected areas is needed ... According to investigators from the Wildlife Conservation Society ... focused on saving the largest numbers of species, often ... and difficult-to-replace ecological functions. , Many vital ... species that also are food for millions of people. ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... , , , , ... Biometrics, Inc. (OTC Bulletin Board: PBME), a leading provider of ... entry into a Loan and Security Agreement with Terry M. Giles, ... In connection with, and as required by the Loan, on ...
... , , , , ... Reportlinker.com announces that a new market research report is available in ... Signature Verification Market , , ... worldwide markets for Dynamic Signature Verification in US$ Thousands. The market ...
... , WALL, N.J., Sept. 14 / PRNewswire-FirstCall / ... a leader in finger-based biometric identification and wireless public safety solutions, ... Advisor and Consultant to the company. Tom will play a major ... the government and commercial markets. , , (Logo: ...
Cached Biology News:Pacific Biometrics Completes $4 Million Debt Financing 2Pacific Biometrics Completes $4 Million Debt Financing 3Pacific Biometrics Completes $4 Million Debt Financing 4Pacific Biometrics Completes $4 Million Debt Financing 5Reportlinker Adds World Dynamic Signature Verification Market Report 2Reportlinker Adds World Dynamic Signature Verification Market Report 3Reportlinker Adds World Dynamic Signature Verification Market Report 4Reportlinker Adds World Dynamic Signature Verification Market Report 5Reportlinker Adds World Dynamic Signature Verification Market Report 6Reportlinker Adds World Dynamic Signature Verification Market Report 7Reportlinker Adds World Dynamic Signature Verification Market Report 8Reportlinker Adds World Dynamic Signature Verification Market Report 9BIO-key Retains Former Senior FBI Official as Strategic Advisor and Consultant 2BIO-key Retains Former Senior FBI Official as Strategic Advisor and Consultant 3BIO-key Retains Former Senior FBI Official as Strategic Advisor and Consultant 4
(Date:8/29/2014)... 2014 The global companion diagnostics ... 2019. It is expected to grow at a ... was valued at $1.8 billion in 2013, according ... Research. , For more information regarding analysis details ... The research report, titled “Companion Diagnostics Market (Breast ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... Due to a misstatement posted by the Family Resource ... Center, LLC ( ASCTC ) was reported as an entity ... benefit ALS patients. Because of ASCTC's exclusive focus on ... therapeutic applications, FRC listed ASCTC as one of several alternatives ... not to support research that requires the death of human ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... -- Theoretical work done at the Department of Energy,s ... understanding an unexpected magnetism between two dissimilar materials. ... special significance for the design of future electronic devices ... of ORNL,s Materials Science and Technology Division. The work ...
... BioMed Realty Trust, Inc. (NYSE: BMR ) today ... September 30, 2010 after the market closes on Wednesday, November ... Chief Executive Officer, Kent Griffin, President, and Greg N. Lubushkin, ... 9:00 a.m. Pacific Time on Thursday, November 4, 2010 to ...
... England, Oct. 18 A 67-year-old female patient with ... tumor was small and it rode up and down ... doctors saw on their therapy system,s imaging equipment was ... Trust was able to utilize its Symmetry™ motion ...
Cached Biology Technology:ORNL theorist part of team that discovers unexpected magnetism 2BioMed Realty Trust to Report 2010 Third Quarter Results 2Clinicians Use Advanced Radiotherapy Imaging Techniques from Elekta to More Accurately Visualize Moving Tumors in Patients with Lung Cancer 2Clinicians Use Advanced Radiotherapy Imaging Techniques from Elekta to More Accurately Visualize Moving Tumors in Patients with Lung Cancer 3
... was developed using a protein engineering approach that ... pocket of wild-type DNase I. These changes markedly ... The result is a versatile enzyme that has ... ability to maintain at least 50% of peak ...
Request Info...
MAb to Mouse MHC Class I H-2Kd...
Rabbit polyclonal antibody to Neuromedin U Receptor 1 (GPR66)...
Biology Products: