Navigation Links
Study identifies new genetic signatures of breast cancer drug resistance
Date:1/10/2011

A new study conducted by Josh LaBaer's research team in the Biodesign Institute at Arizona State University has pinpointed more than 30 breast cancer gene targets ---including several novel genes---that are involved in drug resistance to a leading chemotherapy treatment.

The results of the study may one day aid in the treatment of the one in ten U.S. women who will develop breast cancer, by empowering physicians with a more personalized approach to therapy as well as a new tool for the early screening of those that may ultimately become resistant to chemotherapy.

Drugs like tamoxifen have been part of the standard treatment regimen for many breast cancer patients and saved countless lives. Unfortunately, a very serious therapeutic problem can occur when the drug loses its potency over time as women develop a resistance to the drug treatment, and tumors reemerge. Tamoxifen is an effective treatment for the 60 percent of women who are clinically diagnosed as ER+ (estrogen receptor positive), blocking hormones needed for tumor growth.

"The management of breast cancer is complicated, depending on the stage, size of tumor, and other things, but almost all ER+ women end up on tamoxifen, and it is still considered the first line of adjuvant chemotherapy ---along with resection and local radiation---used in both the early treatment of breast cancer and in late stages of the disease," said LaBaer, who holds the Virginia G. Piper Chair in Personalized Medicine at ASU and is director of the Center for Personalized Diagnostics at the Biodesign Institute. "We wanted to use a model where we could use our high-throughput technology to identify genes that encourage drug resistance to ultimately identify a signature that predicts which women will do well on a particular drug."

Using a well-established cell model for breast cancer along with the LaBaer lab's extensive collection of fully sequenced human genes, the team performed the larges
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study estimates land available for biofuel crops
2. Researchers brave icy waters to study Arctic food web
3. Lake Erie hypoxic zone doesnt affect all fish the same, study finds
4. College students lack scientific literacy, study finds
5. Study finds energy limits global economic growth
6. UF study of lice DNA shows humans first wore clothes 170,000 years ago
7. Catfish study reveals multiplicity of species
8. MIT researchers study the danger of toxoplasma parasites
9. Large-scale study reveals major decline in bumble bees in the US
10. CHOP-led study detects dozens of genes for adult height
11. Penn Medicine researcher receives $6 million grant for cardiovascular disease study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies new genetic signatures of breast cancer drug resistance
(Date:7/11/2014)... When researchers at the National Institute of Standards ... do their work more effectively, they often prove ... Such was the case recently for M. Lorna ... in the growing specialization of glycomics. Glycomics is ... called glycans that are attached to proteins and ...
(Date:7/11/2014)... Ume University, Sweden, have explored two different ways ... sequence leading to the formation of oxygen molecules ... in the scientific journal Nature Communications . ... day synthetic catalysts for water oxidation, which are ... the direct storage of solar energy in fuels ...
(Date:7/11/2014)... that under the normal circumstances, astrocytes participate ... neuronal environment, and exhibit therapeutic and repairing ... Previous studies have found that nerve cells ... induction have reduced viability, which produces influences ... Yuan, Kailuan General Hospital, Hebei United University, ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... WI, MARCH 29, 2011 The environmental concern is ... the plant-soil relationship. Understanding plant,s absorption and accumulation of ... One highly carcinogenic contaminant commonly found in soil ... of the incomplete combustion of coal, oil, gas, and ...
... tell a story, these bleached bones that gleam in ... landscapes like Yellowstone may provide detailed accounts of how ... or even century, scientists have found. "The skeletons ... into our understanding of ecosystem history, especially how populations ...
... Researchers at the University of Michigan Comprehensive Cancer Center ... treat multiple types of cancer. A study, published this ... that AT-406 effectively targets proteins that block normal cell death ... while not harming normal cells. The researchers believe the drug ...
Cached Biology News:Bones of long-dead animals conjure ghosts at Yellowstone 2Bones of long-dead animals conjure ghosts at Yellowstone 3New cancer drug discovered at U-M heads to clinical trials 2
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... hours a day now that a new company has created ... site MusicMadeInMadison.com plays more than 450 songs written ... Burn, Infinite Helix and They Drive By Night. Founded in ... to help both the circulation of the artists and awareness ...
... a lot of Web developers realized some time ago: Flash ... be supported as one. , , In announcements made today ... current and future components of the Flash development platform like ... of course, is the Flash player itself, which is now ...
... and the Wisconsin Technology Council have released a report ... and the difficulties that still need to be addressed ... , ,Wisconsin Technology Council President Tom Still pointed ... Massachusetts have lost 10 to 15 percent of their ...
Cached Biology Technology:Flashing into the future 2Flashing into the future 3Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 2Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 3
... has over 23 years of experience in ... have made antibodies to large and small ... antigens, and plasmid DNA-encoded antigens. We understand ... so our hybridoma development programs are never ...
... Rapid-Screen cDNA Library Panels were designed for ... sets of PCRs to identify the desired ... performed in a 96-well "Master Plate," where ... clones. Having identified the positive well(s) by ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... CBED Maxi Kit provides a fast and ... protein solutions for buffer exchange, and for removing ... kit is based on spin-column chromatography using Norgens ... such as MgCl 2 , NaCl, KCl, CaCl ...
Biology Products: