Navigation Links
Study identifies liver gene that regulates cholesterol and fat blood levels
Date:2/7/2013

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemiaabnormal blood cholesterol levels that can contribute to heart disease. Study details published in the February issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), describe a new in silico approach to identify the significance of microRNAs in regulating disease-related gene pathways.

The Human Genome Project (HGP) was completed in April, 2003 and the world had a map of the 3 billion DNA letters making up the human genome. One of the HGP leaders was Dr. Francis Collins, currently NIH Director and contributor to the present study. "The HGP provided the basic instruction book for human biology," explains Dr. Collins. "Further genomic studies, such as the investigation of microRNAs, have built upon the efforts of the HGP to explain how the genome carries out its functions, and helps identify genes involved in the development of disease."

For the present study, lead author Dr. Kasey Vickers from the NIH/NHLBI Lipoprotein Metabolism Section (presently at Vanderbilt University School of Medicine) and colleagues performed high-throughput small RNA sequencing of mouse liver and detected roughly 150 microRNAs. The team used a novel in silico approach to identify microRNA regulatory hub genes involved in lipid metabolism. In human and mouse livers miR-27b was determined to be the strongest hub with 27 predicted targets.

"We found liver miR-27b levels to be sensitive to high triglycerides (hyperlipidemia) in the blood and liver," said Dr. Vickers. The team reported a nearly 3-fold increase in miR-27b levels in the liver of mice on a high-fat diet, with 42% of calories from fat. In human liver tissue cells, researchers determined that miR-27b regulates mRNA and protein expression of key lipid-metabolis
'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows disease spread in ladybirds with sexually transmitted disease
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Study of a rare disease making people look like a woman but having male genitals under study
4. Study finds potential to match tumors with known cancer drugs
5. Can plants be altruistic? You bet, says new CU-Boulder-led study
6. New study sheds light on link between dairy intake and bone health
7. Medical societies to launch large-scale study on vein filter use
8. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
9. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
10. New Geology study raises questions about long-held theories of human evolution
11. New study highlights impact of environmental change on older people
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... news release is available in German . ... as individuals prompt our fellow humans to behave socially? ... social dilemmas in game theory. Previous studies assumed that ... groups. Nonetheless, scientists from the Max Planck Institute for ... can exert an influence on the cooperative behaviour of ...
(Date:10/30/2014)... New York | Heidelberg, 30 October 2014 Biological ... a better understanding of adsorption of solution ions ... biological cells. Now, a new study provides a ... and surrounding solution ions. Joanna Kotyńska and Zbigniew ... the authors of a study describing these findings, ...
(Date:10/29/2014)... date, researchers have used DNA sequencing to uncover dozens ... Buxbaum, Ph.D., Icahn School of Medicine at Mount Sinai, ... Harvard and MIT, and their colleagues examined more than ... people. They identified changes in 107 genes that are ... disorder (ASD) – a jump from the nine genes ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Ion adsorption matter in biology 2
... when combined, could be involved in the earliest stages ... targeted therapies aimed at slowing or preventing the onset ... normal gene in a tumor cell a gene ... reactivated," says David Jones, Ph.D., professor of oncological sciences ...
... TV knows that forensic scientists can use DNA profiling ... scene, establish a paternity link or help free an ... known but rapidly growing application of DNA profiling is ... genealogy. The laboratories performing this testing often differ in ...
... team at the Stowers Institute has discovered how the expression ... in a specific segment of the developing brain. The findings ... some of its unique and important structures. The ... Proceedings of the National Academy of Science today. ...
Cached Biology News:Newly found enzymes may play early role in cancer 2NIST guides genetic genealogy labs toward improved accuracy 2Krumlauf Lab demonstrates modulation of gene expression by protein coding regions 2
(Date:10/31/2014)... 2014  Tavistock Development Co. (TDC), a diversified ... groundbreaking of the GuideWell Innovation Center ... The 92,000-square-foot, three-story facility is the first multi-tenant ... designed specifically for life sciences, health innovation, and ... 650-acre Lake Nona Medical City, near the Sanford-Burnham ...
(Date:10/30/2014)... , October 30, 2014 Investor-Edge ... Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... Synthetic Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,549.23, down 0.33%, the Dow Jones Industrial Average ...
(Date:10/30/2014)... October 30, 2014 2014 Deep ... Industryā€¯ is a professional and in-depth research report ... basic Naltrexone HCL information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:10/30/2014)... Diego, CA (PRWEB) October 30, 2014 ... announced today that they have manually curated public data ... and non profit customers. the data is now ... manually curates and unifies public and internal data sources ... value and knowledge out of the data that becomes ...
Breaking Biology Technology:GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Rancho BioSciences Manually Curated TCGA Data Sets Available 2
... Phytomedics Inc., a clinical,stage biopharmaceutical company developing ... it will present at the,Wachovia 2008 Healthcare Conference ... p.m. ET., Among the topics of the ... and business developments, including Phase III development,activities related ...
... (OTC:,NNLX - News) a nano-biotechnology company is pleased ... development at a,Welch,s juice plant in Pennsylvania has ... Allegheny Front" - Environmental Radio for Western,Pennsylvania". The ... aired,January 23rd on WYEP- FM, a listener-supported public ...
... Corporation today,announces that Mr. Mark Ostrowski has joined ... Mr. Ostrowski will be responsible for overseeing,the growth ... and,marketing efforts in support of the substantial momentum ... has more than 17 years experience in biotechnology ...
Cached Biology Technology:NanoLogix's Hydrogen-From-Waste Technology at Welch's Foods Featured on Environmental Radio Program 2Mark Ostrowski Joins GenVault as Vice President of Sales and Marketing 2
... System (Ruggedized Advanced Pathogen Identification Device) ... designed for field hospitals, mobile laboratories ... to its ruggedness, it is designed ... as the LightCycler instrument. By taking ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... for its amino acid acceptor activity using aminoacyl-tRNA ... Asp, Gly, Ile, Lys, Pro, Thr, Val, Arg, ... Definition: One unit will yield an A 260 ... (1 cm light path). Physical Form: ...
... Unique, compact measuring instrument for calibrating ... compact design and the robust carrying case, ... both in the laboratory and on-site at ... easy to use because the individual channels ...
Biology Products: