Navigation Links
Study identifies key cause of chronic leukemia progression
Date:3/4/2010

COLUMBUS, Ohio Researchers have discovered a key reason why a form of leukemia progresses from its more-treatable chronic phase to a life-threatening phase called blast crisis.

The study, led by cancer researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James), indicates that chronic myeloid leukemia (CML) progresses when immature white blood cells lose a molecule called miR-328.

Loss of the molecule traps the cells in a rapidly growing, immature state. The cells soon fill the bone marrow and spill into the bloodstream, a tell-tale sign that the disease has advanced to the blast crisis stage.

The research, published in the March 5th issue of the journal Cell, should provide a better understanding of the blast-crisis stage of CML, and it suggests a possible new treatment strategy for the disease, the researchers say.

"These findings indicate that the loss of miR-328 is probably essential for progression from the chronic phase of the disease to the blast crisis stage," says principal investigator Danilo Perrotti, associate professor of molecular virology, immunology and medical genetics and a member of the OSUCCC-James.

"Our findings also suggest that maintaining the level of this microRNA might represent a new therapeutic strategy for CML blast crisis patients who do not benefit from targeted agents such as imatinib (Gleevec) and dasatinib (Sprycel)," Perrotti says

The study also revealed a new function for microRNA. Researchers have known for some time that these molecules help regulate the kinds of proteins that cells make. But this study shows for the first time that microRNA molecules can also attach directly to protein molecules and alter their function.

In this case, miR-328 binds to a protein that prevents immature blood cells from maturing. "We believe that it normally acts as a decoy molecule, tying up the protein and enabling the white blood cells to mature as they should," Perrotti says.

During CML progression, however, the level of miR-328 drops, allowing the protein to be extremely active. This keeps the leukemic white blood cells from maturing and contributes to the transition from the chronic-disease phase to blast crisis phase.

"These findings may help unravel novel pathways responsible for the initiation and progression of leukemia generally," Perrotti says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related biology news :

1. Study shows woody plant encroachment has increased stream flow in the Edwards Plateau
2. New study shows teens who drink 100 percent fruit juice have more nutritious diets overall
3. Study: Climate change one factor in malaria spread
4. Kids lose pounds, gain fitness in Houston study
5. An apple a day? Study shows soluble fiber boosts immune system
6. MMS and NOAA scientists study prey of Gulf of Mexico sperm whales
7. Study finds dirty air in California causes millions worth of medical care each year
8. New technique allows study of protein folding, dynamics in living cells
9. Study: Gene therapy reverses effects of lethal childhood muscle disorder in mice
10. UAB study shows African-Americans have highest stroke rate, southerners more likely to die
11. New University of Colorado paper shows novel way to study human inflammatory disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:5/21/2017)... , ... May 20, 2017 , ... ... helps avoid the lengthy trial and error process by finding the right antidepressant ... can also strengthen the doctor-patient relationship through a personalized approach to treatment. ...
(Date:5/18/2017)... ... 2017 , ... Dr. Ralph Mobbs of the Neuro Spine ... Private Hospital. The procedure was performed on a 46-year-old male patient suffering from ... to undergoing surgery. , The AxioMed viscoelastic disc is a next-generation disc replacement ...
(Date:5/18/2017)... ... May 17, 2017 , ... NDA Partners Chairman Carl ... CEO of Eurofins Advantar Laboratories and President of Pharmaceutical Development Business Unit of Cardinal ... at Eurofins and Cardinal Health, he was former Chief Operating Officer at Anaborex, Senior ...
(Date:5/18/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... May 17, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the Chairman of the UDIs and Traceability for Medical Devices conference in Brussels, ...
Breaking Biology Technology: