Navigation Links
Study identifies how muscles are paralyzed during sleep
Date:7/11/2012

TORONTO, ON Two powerful brain chemical systems work together to paralyze skeletal muscles during rapid eye movement (REM) sleep, according to new research in the July 11 issue of The Journal of Neuroscience. The finding may help scientists better understand and treat sleep disorders, including narcolepsy, tooth grinding, and REM sleep behavior disorder.

During REM sleep the deep sleep where most recalled dreams occur your eyes continue to move but the rest of the body's muscles are stopped, potentially to prevent injury. In a series of experiments, University of Toronto neuroscientists Patricia L. Brooks and John H. Peever, PhD, found that the neurotransmitters gamma-aminobutyric acid (GABA) and glycine caused REM sleep paralysis in rats by "switching off" the specialized cells in the brain that allow muscles to be active. This finding reversed earlier beliefs that glycine was a lone inhibitor of these motor neurons.

"The study's findings are relevant to anyone who has ever watched a sleeping pet twitch, gotten kicked by a bed partner, or has known someone with the sleep disorder narcolepsy," said Dennis J. McGinty, PhD, a behavioral neuroscientist and sleep researcher at the University of California, Los Angeles, who was not involved in the study. "By identifying the neurotransmitters and receptors involved in sleep-related paralysis, this study points us to possible molecular targets for developing treatments for sleep-related motor disorders, which can often be debilitating," he said

The researchers measured electrical activity in the facial muscles responsible for chewing of sleeping rats. Brain cells called trigeminal motor neurons communicate the brain's message to move to these muscles. Previous research suggested neurotransmitter receptors called ionotropic GABAA/glycine receptors in the motor neurons caused REM sleep paralysis. However, when the researchers blocked these receptors, REM sleep paralysis still occur
'/>"/>

Contact: Michael Kennedy
m.kennedy@utoronto.ca
416-946-5025
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... or even improve the state of fisheries resources ... the Mediterranean has deteriorated over the past 20 ... species reported in the Cell Press journal ... for stringent monitoring of Mediterranean fishing activities, better ... in Mediterranean waters. , Their data show that ...
(Date:7/10/2014)... for Interdisciplinary Research (MIIR) and the Marshall University ... they will be partnering with an international biosciences ... the agreement with Shanghai-based HD Biosciences Co. Ltd., ... risks of discovery and development of these new ... property and commercialization rights to products developed through ...
(Date:7/10/2014)... incubator, received a $1.4 million federal grant to develop ... bleeding during brain surgery. , Surgeons can spray the ... solutions in the gel will cohere and control bleeding ... gel can shorten an intracranial surgery by 30- 45 ... patient,s skull to be open and less anesthesia, reducing ...
Breaking Biology News(10 mins):Mediterranean fish stocks show steady decline 2Marshall University to partner with international company in drug development venture 2A start-up at NJIT develops bleeding-control gel for brain surgery 2
... LEXINGTON, Ky. (July 13, 2009) Researchers at ... Center for Toxicology (GCT) have gained new insight into ... or neuromuscular disorders caused by trinucleotide repeats (or TNRs) ... laboratory of Dr. Guo-Min Li, UK professor of toxicology ...
... no surprise that some babies are more difficult to soothe ... that this is not necessarily an indication of their parenting ... , a journal of the Association for Psychological Science, children,s ... a certain gene and a specific pattern of brain activity. ...
... one of the best known and extensively studied organisms in ... to human diseases, such as cancer. The team, funded ... at the University of Dundee has examined the genome sequence of ... that, it turns out, are essential for the survival of ...
Cached Biology News:Researchers gain insight into mechanism underlying Huntington's 2Hush little baby... Linking genes, brain and behavior in children 2Mystery E. coli genes essential for survival of many species 2
(Date:7/10/2014)... 10, 2014 Terascala, the industry leader ... Alan Swahn, a former vice president of product management ... vice president of marketing. Terascala’s software when combined with ... create the highest performance and most reliable solutions for ... guide Terascala’s channel expansion and broaden its product portfolio. ...
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
(Date:7/10/2014)... the journal PNAS (Proceedings of the National Academy ... and sleep deprivation have a significant effect on our ... the best time of day to test for diseases ... medicines effectively. , Researchers from the University of Surrey ... links between sleep deprivation, body clock disruption and metabolism, ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2
... CRACKS AMAZON.COM BEST SELLER LIST IN SCIENCE , Signature ... science books , SEATTLE, Nov. 17 Despite Darwinists, attempts ... controversial theory of intelligent design made Amazon.com,s list of the year,s ... 150 years since Charles Darwin published his own theory in his ...
... Hungary, Nov. 17 Hungarian drug producer Biropharma and ... connection American BioSciences Inc. and its partner Mate Hidvegi ... Avemar, a dietary supplement being used in cancer treatment ... two different sets of compounds hence the qualities of ...
... ... (DOE) Argonne National Laboratory has been awarded the HPCwire,s Readers, Choice Award for Best ... HPCwire, at the annual Supercomputing Conference (SC09), currently ongoing in Portland, Ore. , ... Portland, OR (Vocus) Nov. ...
Cached Biology Technology:Intelligent Design Book Delivers Blow to Darwin 2Hungarian Cancer Formula Producer Questions U.S. Introduction of AveUltra 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 3Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 4
Shake 'n' Stack oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual)...
... - Neurosphere is a system designed for ... neurospheres in a serum free environment. The kit ... which has been optimized for neural stem cell ... Genes & Development 10 :3129). Two growth ...
Request Info...
... RQ1 RNase-Free DNase is a ... single-stranded or double-stranded DNA to produce ... for use in applications where maintaining ... RQ1 DNase is qualified for use ...
Biology Products: