Navigation Links
Study identifies genetic variants giving rise to differences in metabolism
Date:11/27/2008

Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics. An international team of researchers, led by Karsten Suhre, has conducted a genome-wide association study with metabolomics, identifying genetic variants in genes involved in the breakdown of fats. The resulting differences in metabolic capacity can affect individuals' susceptibility to complex diseases such as diabetes and hyperactivity.

In the rapidly evolving field of metabolomics, scientists aim to measure all endogenous metabolites in a cell or body fluid. These measurements provide a functional readout of the physiological state of the human body. Investigation into these so-called "genetically determined metabotypes" in their biochemical context may help determine the pathogenesis of common diseases and gene-environment interactions.

The team identified four single nucleotide polymorphisms (SNPs) located in genes coding for well-characterized enzymes of the lipid metabolism. Individuals with different genotypes in these genes have significantly different metabolic capacities with respect to the synthesis of some polyunsaturated fatty acids, the beta-oxidation of short- and medium-chain fatty acids and the breakdown of triglycerides. By simultaneous measurements of both SNPs and serum concentrations of endogenous metabolites, the researchers determined the metabolome of several hundred healthy individuals and compared it to their genetic inheritance.

The results suggest that most individuals carry one or more risk alleles in their genetic inheritance that may determine a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge. These findings may lead to more targeted approaches to health care based on a combination of genotyping and metabolic characterization. To achieve this goal, it will be necessary to identify the major genetically determined metabotypes and their association to complex diseases.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Related biology news :

1. UNC expands brain imaging study of infants at risk for autism
2. Shrimp trawling may boost mercury in red snapper, study suggests
3. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
4. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
5. Hairspray is linked to common genital birth defect, says study
6. Carbon dioxide already in danger zone, warns study
7. Duke study pinpoints potential green collar job growth in US
8. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
9. Montana State researchers receive grant to study algae as a source of biofuel
10. UBC study establishes formula for predicting climate change impact on salmon stocks
11. Study a step toward disease-resistant crops, sustainability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... , ... Panitch Schwarze Belisario & Nadel intellectual ... Innovation Group) annual meeting in China. , This year’s meeting, held June 9-10 ... a rapidly developing highly personalized anti-cancer technology that involves removing some of a ...
(Date:7/17/2017)... ... July 17, 2017 , ... DuPont Pioneer ... A website (openinnovation.pioneer.com) dedicated to connecting third-party innovators with DuPont Pioneer ... plant breeding, enabling technologies, biologicals and digital solutions. , “DuPont Pioneer is building ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS ... announced the launch of its new line of Extreme Environment Shakers today. , ... require CO2 and humidity for optimal cell growth such as cell cultures, solubility ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies is proud ... installed a solar system on its roof top. “We will be independent of ... Kenneth Raab stated. The company’s proud history of social responsibility and participation in ...
Breaking Biology Technology: