Navigation Links
Study identifies genetic variants giving rise to differences in metabolism
Date:11/27/2008

Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics. An international team of researchers, led by Karsten Suhre, has conducted a genome-wide association study with metabolomics, identifying genetic variants in genes involved in the breakdown of fats. The resulting differences in metabolic capacity can affect individuals' susceptibility to complex diseases such as diabetes and hyperactivity.

In the rapidly evolving field of metabolomics, scientists aim to measure all endogenous metabolites in a cell or body fluid. These measurements provide a functional readout of the physiological state of the human body. Investigation into these so-called "genetically determined metabotypes" in their biochemical context may help determine the pathogenesis of common diseases and gene-environment interactions.

The team identified four single nucleotide polymorphisms (SNPs) located in genes coding for well-characterized enzymes of the lipid metabolism. Individuals with different genotypes in these genes have significantly different metabolic capacities with respect to the synthesis of some polyunsaturated fatty acids, the beta-oxidation of short- and medium-chain fatty acids and the breakdown of triglycerides. By simultaneous measurements of both SNPs and serum concentrations of endogenous metabolites, the researchers determined the metabolome of several hundred healthy individuals and compared it to their genetic inheritance.

The results suggest that most individuals carry one or more risk alleles in their genetic inheritance that may determine a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge. These findings may lead to more targeted approaches to health care based on a combination of genotyping and metabolic characterization. To achieve this goal, it will be necessary to identify the major genetically determined metabotypes and their association to complex diseases.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Related biology news :

1. UNC expands brain imaging study of infants at risk for autism
2. Shrimp trawling may boost mercury in red snapper, study suggests
3. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
4. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
5. Hairspray is linked to common genital birth defect, says study
6. Carbon dioxide already in danger zone, warns study
7. Duke study pinpoints potential green collar job growth in US
8. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
9. Montana State researchers receive grant to study algae as a source of biofuel
10. UBC study establishes formula for predicting climate change impact on salmon stocks
11. Study a step toward disease-resistant crops, sustainability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... -- Hunova, the first robotic gym for the rehabilitation and functional motor sense ... Genoa, Italy . The first 30 robots will be available ... USA . The technology was developed and patented at the IIT ... Movendo Technology thanks to a 10 million euro investment from entrepreneur Sergio ... ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/16/2017)... --  Bridge Patient Portal , an enterprise patient ... Systems , an electronic medical record solutions developer ... a partnership to build an interface between the ... products, including Centricity Practice Solution (CPS), Centricity Business ... integrations will allow healthcare delivery networks using GE ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... 2017 , ... Activate Healthcare, a leading provider of on-site ... growing private companies, has selected Twine for its Employee Health Activation Platform. Activate ... model that empowers deep collaboration and behavior change. In randomized controlled trials, Twine ...
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this ... studies, describing how process development and economic goals were achieved in both industry ... a hollow-fiber bioreactor system, along with techniques for scaling production of mesenchymal stem ...
(Date:5/26/2017)... ... 25, 2017 , ... Studying biological events while they happen ... imaging using fluorescence microscopy is the perfect approach to explore these complex questions. ... be discussed, from small animal models and tissues to individual organelle and protein ...
(Date:5/26/2017)... ... May 25, 2017 , ... LabRoots , the leading ... scientists from around the world, is announcing a new textbook scholarship, the second scholarship ... and graduate students, 17 years or older, pursuing a degree in one of the ...
Breaking Biology Technology: