Navigation Links
Study identifies gene tied to motor neuron loss in ALS
Date:1/23/2014

nactivating MMP-9 is not a cure," said Dr. Henderson. "But it's remarkable that lowering levels of a single gene could have such a strong effect on the disease. That's encouraging for therapeutic purposes."

The researchers are still investigating how MMP-9 affects motor neuron function. Their findings suggest that the protein plays a role in increasing stress on the endoplasmic reticulum, an organelle involved in transporting and processing materials within cells. "Our goal is to learn more about MMP-9 and related pathways and to identify a new set of therapeutic targets," said Dr. Henderson.

The paper is titled, "Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration." The other contributors are Christopher Towne (Brain Mind Institute, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland), Kevin C. Kanning (CUMC), Ginn T. Choe (CUMC), Adam Geber (CUMC), Turgay Akay (CUMC), and Patrick Aebischer (Brain Mind Institute).

MMP-9 inhibitors developed for cancer have not been successful in that context. The authors hope that this study will encourage companies to explore clinical testing of such drugsor other modes of MMP-9 inhibitionin patients with ALS.


'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study says sharks/rays globally overfished
2. New CU-Boulder study shows differences in mammal responses to climate change
3. Drug alternatives to antibiotics may not be perfect, study shows
4. Study: Electric drive vehicles have little impact on US pollutant emissions
5. New study reveals links between alcoholic liver disease and the circadian clock
6. A CNIO study finds a molecular scaffolding that maintains skin structure and organisation
7. Wild sparrow study traces social behaviors in the field to specific gene
8. Illinois study identifies 3 risk factors most highly correlated with child obesity
9. Multiple myeloma study uncovers genetic diversity within tumors
10. Nature study discovers chromosome therapy to correct a severe chromosome defect
11. Study shows large carnivore numbers and range declining worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies gene tied to motor neuron loss in ALS
(Date:8/31/2014)... is developing drugs that are highly effective against a ... patient. Such properties are directly related to the 3D ... have a shape that is perfectly complementary to a ... specificity. Publishing in Nature Chemistry , EPFL scientists ... the 3D structure of bioactive peptides and enhance their ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current ... exceed, the global targets for total greenhouse gas (GHG) emissions ... all think carefully about the food we choose and its ... is just one of a number of actions that need ... there is enough food for all. , As populations ...
(Date:8/29/2014)... have made some surprising discoveries about the body,s ... virus (SIV), the team found that specialized cells ... responders to viral invasion and are the source ... interleukin-1 beta (IL-1β). , Though aimed at ... the gut epithelium that provides a barrier to ...
Breaking Biology News(10 mins):A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4The early cost of HIV 2
... in billions, sometimes - like the snow bunting ... distances and enduring the most extreme frigid weather conditions. ... a stunning success of biological adaptation with Snow ... north as the Arctic Circle. Indeed, there is nothing ...
... be a household name even among farm families, but ... environmentally-friendly commercial biofuel feedstock, particularly for biodiesel and jet ... has just awarded $5.08 million to a team of ... Grain Science and Industry, Xiuzhi "Susan" Sun, to study ...
... coughs, soot or black carbon turns out to ... only to carbon dioxide, according to a four-year assessment by ... the soot particles in smoke and smog, contributes about twice ... the 2007 Intergovernmental Panel on Climate Change. "We were surprised ...
Cached Biology News:Novel approach to track migration of arctic-breeding avian species 2Novel approach to track migration of arctic-breeding avian species 3Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock 2Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock 3International study: Where there's smoke or smog, there's climate change 2International study: Where there's smoke or smog, there's climate change 3
(Date:8/29/2014)... San Antonio, TX (PRWEB) August 29, 2014 ... 9001:2008 and ISO 13485:2003 certified, GAMP® 5 compliant ... been awarded an international Phase II clinical trial ... non-Hodgkin’s lymphoma. , Throughout this trial, Intrinsic Imaging ... but not limited to, protocol and charter development, ...
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., a leader ... processing industry, is asking industry professionals to prepare for ... the E2 soap they’re currently using to the Best ... Hand hygiene is critical to fighting cross-contamination and ... Six key criteria are identified to evaluate the effectiveness ...
(Date:8/28/2014)... Lawrence, MA (PRWEB) August 28, 2014 “This ... single test to screen from 0 to 150 ppb,” said ... test is a significant benefit to plant owners and USDA-GIPSA ... corn and other commodities. Testing can take place in a ... Not only can the plant test the feed and grain ...
(Date:8/28/2014)... important devices in spintronics, an electronic which is ... but also on their spin and the spin-related ... into magnetic signals and vice versa. Recently, the ... Institute of Physics at Johannes Gutenberg University Mainz ... and Japan, has for the first time realised ...
Breaking Biology Technology:Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3
... Neuftec,Limited, the proprietor of the original nano-particulate ... litigation in the,UK against Oxonica Energy Limited, a ... issued in the High Court of Justice, allege ... an injunction against Oxonica as well as damages,in ...
... Senesco,Technologies, Inc. ("Senesco" or the "Company") (Amex: ... presenting at the Business Forum during BIO 2008,the ... held at the San Diego Convention Center from ... Senesco, will deliver the,Company,s corporate presentation on Wednesday, ...
... CHURCH, Va., June 12 CSC (NYSE: ... HealthTrio LLC to add portal and personal,health record ... and other payer clients. The added components include ... October 2007, FirstPortfolio provides users with a,collection of ...
Cached Biology Technology:Neuftec Issues Patent Infringement Proceedings in the UK Against Oxonica 2Senesco Technologies to Present at BIO 2008 Business Forum 2CSC and HealthTrio Team to Offer Portal and Personal Health Record Solution 2CSC and HealthTrio Team to Offer Portal and Personal Health Record Solution 3
... Glycosylation is a post-translational modification ... biological functions, including immune regulation, inflammation, ... Biotechnology has developed two lectin based ... and Wheat Germ Agglutinin (WGA), that ...
... carrier proteins to simplify the production ... Carrier Proteins are commonly used carriers ... heterobifunctional cross-linker (Sulfo-SMCC). This activation results ... Thus allowing the maleimide-activated carrier ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Cell Culture Flask, nontreated polystyrene...
Biology Products: