Navigation Links
Study identifies gene tied to motor neuron loss in ALS
Date:1/23/2014

NEW YORK, NY (January 22, 2014) Columbia University Medical Center (CUMC) researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

"One of the most striking aspects of ALS is that some motor neuronsspecifically, those that control eye movement and eliminative and sexual functionsremain relatively unimpaired in the disease," said study leader Christopher E. Henderson, PhD, the Gurewitsch and Vidda Foundation Professor of Rehabilitation and Regenerative Medicine, professor of pathology & cell biology and neuroscience (in neurology), and co-director of Columbia's Motor Neuron Center. "We thought that if we could find out why these neurons have a natural resistance to ALS, we might be able to exploit this property and develop new therapeutic options."

To understand why only some motor neurons are vulnerable to ALS, the researchers used DNA microarray profiling to compare the activity of tens of thousands of genes in neurons that resist ALS (oculomotor neurons/eye movement and Onuf's nuclei/continence) with neurons affected by ALS (lumbar 5 spinal neurons/leg movement). The neurons were taken from normal mice.

"We found a number of candidate 'susceptibility' genesgenes that were expressed only in vulnerable motor neurons. One of those genes, MMP-9, was strongly expressed into adulthood. That was significant, as ALS is an adult-onset disease," said co-lead author Krista J. Spiller, a former graduate student in Dr. Henderson's laboratory who is now a postdoctoral fellow at the University of Pennsylvania. T
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study says sharks/rays globally overfished
2. New CU-Boulder study shows differences in mammal responses to climate change
3. Drug alternatives to antibiotics may not be perfect, study shows
4. Study: Electric drive vehicles have little impact on US pollutant emissions
5. New study reveals links between alcoholic liver disease and the circadian clock
6. A CNIO study finds a molecular scaffolding that maintains skin structure and organisation
7. Wild sparrow study traces social behaviors in the field to specific gene
8. Illinois study identifies 3 risk factors most highly correlated with child obesity
9. Multiple myeloma study uncovers genetic diversity within tumors
10. Nature study discovers chromosome therapy to correct a severe chromosome defect
11. Study shows large carnivore numbers and range declining worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies gene tied to motor neuron loss in ALS
(Date:7/31/2015)... China , 31. Juli 2015 Die 10. ... wird von BGI veranstaltet und findet vom 22. ... China , statt. Die ... Seit ihrem Start 2006 ist die ICG weltweit ... „omik" geworden. Sie ist eines der dynamischsten, enthusiastischsten ...
(Date:7/31/2015)... SHENZHEN, China , July 31, 2015 The ... ) will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th ... become one of the world,s most influential annual meetings in ... enthusiastic, and enjoyable scientific gatherings. ICG-10 focuses ...
(Date:7/27/2015)... JOSE, Calif. , July 27, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... ® touchscreen solution for its stylish smartwatch. ... for its proven reliability, low power and highly ... a wet finger. Huawei designers also required a ...
Breaking Biology News(10 mins):Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... at the leaves on a plant and noticed their various ... size and shape of each individual leaf? Very little is ... and understanding the mechanisms behind this is a major issue ... determined by a combination of cell number, cell size, and ...
... evolved over hundreds of generations to infect bacteria. They ... evolved at a quicker rate and generated greater diversity, compared ... the viral infection. The study shows, for the first ... correct in his ,Red Queen Hypothesis,. The theory, first ...
... What are the top research questions facing agriculture? Earlier this ... opinions of its members and leadership to develop a Grand ... ASA Grand Challenge The Society -- through a ... "Grand Challenge" statement that encompasses the future of agriculture: ...
Cached Biology News:Can a single layer of cells control a leaf's size? 2Can a single layer of cells control a leaf's size? 3Scientists reveal driving force behind evolution 2What is the 'grand challenge' facing the future of agriculture? 2
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience ... meeting of the Japan Society of HTLV-1, held this ... Auditorium. The purpose of the Society is to promote ... the development of medical technology and research related to ... welfare. "HUYA is proud to support this ...
(Date:8/27/2015)... ... 27, 2015 , ... METTLER TOLEDO's web-based EasyFinder™ ... choices to a manageable shortlist of bench and floor scales and terminals. Specifying ... best with the customer’s industry and application. , Side-by-side product comparisons and ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, a leader in ... is to open in Manhattan, Kansas in early October, 2015. The location of ... research and development through collaboration with researchers from Kansas State University’s College of ...
(Date:8/26/2015)... Maryland Heights, MO (PRWEB) , ... August 26, ... ... is announcing it is increasing its investment in the development and manufacture of ... increase demand. The company’s scientific team's extensive expertise with protein chemistry has ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4METTLER TOLEDO Updates Online Scale Selection Tool 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2
... The Tauri Group LLC is pleased,to announce that ... and,Technical Assistance (SETA) support for the U.S. Department ... Detection Division Chemical,and Biological Early Detection (CBED) program. ... the period of performance is three years and ...
... Dec. 11 Replikins Ltd. today announced its,latest ... H5N1 influenza,virus. The company,s software-driven analysis has found ... in Indonesia; in addition, higher,counts now have been ... this gene which has been linked to the ...
... Inventory Management, Disposables ... Colo., Dec. 11 , WHAT: This presentation identifies key challenges facing ... supplies and explains how embedded RFID ... that enhances safety and reliability, increases ...
Cached Biology Technology:The Tauri Group LLC Awarded U.S. Department of Homeland Security Chemical and Biological Early Detection Systems Program Office Support Contract 2Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated 2SkyeTek to Present Webinar on Transforming the Management of Medical Devices & Supplies with Embedded RFID 2