Navigation Links
Study highlights possible new approach to prostate cancer treatment
Date:8/1/2013

CINCINNATI -- A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer.

Conducted at Cincinnati Children's Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study appears in the journal's Aug. 2 edition.

The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis -- the spread of cancer to other organs of the body.

"It is possible that FoxM1 is important for both cancer initiation and cancer progression," says Tanya Kalin, MD, PhD, a physician-scientist in the division of Pulmonary Biology at Cincinnati Children's and senior author of the study. "Our findings provide the foundation for the development of new therapeutic approaches based on inhibition of FoxM1."

FoxM1 is known to be involved in most solid tumor cancers. Kalin's lab published a study in 2006 showing that increased levels of FoxM1 were associated with the development and progression of prostate cancer in mice. Although the current study focuses primarily on prostate cancer, the findings could also help researchers better understand the pathogenesis of pediatric disease.

In this new study, Kalin and colleagues at Cincinnati Children's studied a novel mouse model of prostate cancer. In this model, loss of FoxM1 decreased tumor growth and metastasis. Without this model, over-expression of FoxM1, either alone or in combination with inhibition of a tumor suppressor known as p19ARF caused a robust proliferation of epithelial cells. This proliferation of cells was not enough to induce progression from proliferation to actual prostate cancer, but it caused small prostate epithelial tubes to shrink.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. Breath analysis reliably indicates presence, level of infection in mice, UCI study finds
2. Southerners are less trusting, but trust is a factor in environmental cooperation, study shows
3. Study investigates extraordinary trout with tolerance to heavily polluted water
4. Extinct ancient ape did not walk like a human, study shows
5. Study explains Pacific equatorial cold water region
6. Study finds depletion of alveolar macrophages linked to bacterial super-infections
7. New study finds nighttime heat waves increasing in Pacific Northwest
8. Study finds missing piece of pediatric cancer puzzle
9. Its not just the heat -- its the ozone: Study highlights hidden dangers
10. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
11. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has ... Global Strategic Business Report" report to their offering. ... in US$ Thousands by the following Segments: Face Biometrics, and Voice ... Canada , Japan , ... East & Africa , and ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... a new and potentially important mechanism by which chemical ... clouds that reflect sunlight away from our planet. ... and the biosphere grew out of efforts to explain ... Southern Ocean where a large bloom of phytoplankton was ...
... that the Chlamydia bacterium, which causes a sexually transmitted ... shared evolutionary heritage, which is not found in most ... of an effective cure for Chlamydia infections. , "The ... been proposed by others," said Thomas Leustek," a professor ...
... broadens our understanding of primate cooperation, researchers have ... and draw on an evolutionarily old principle--shared with ... that produces flexible, adaptive, and cooperative responses by ... is reported by Kimberley Hockings and James Anderson ...
Cached Biology News:Researchers link ocean organisms with increased cloud cover and potential climate change 2Researchers link ocean organisms with increased cloud cover and potential climate change 3Researchers link ocean organisms with increased cloud cover and potential climate change 4Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia 2Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia 3Road-crossing in chimpanzees: A risky business 2
(Date:4/16/2015)... 16, 2015 The Council for ... prestigious 2015 Borlaug CAST Communication Award goes to ... Tuskegee University in Alabama. Award nominees must demonstrate ... presentations; and/or the use of television, radio, or ... areas. As a specialist in the field of ...
(Date:4/16/2015)... /CNW/ - Bioenterprise Corporation is pleased to announce that it ... Charlottetown , PEI.  Bioenterprise has established a 3-year ... for the commercialization of agricultural technologies and innovations. ... ADAPT.  They have been at the heart of agri-innovation ... Dave Smardon , President & CEO of Bioenterprise ...
(Date:4/16/2015)... April 16, 2015  Scientists from Cleave Biosciences will ... the Horizon," at the American Association for Cancer Research ... on Sunday, April 19, 2015 from 3:15pm to ... of Biology, will present new in vivo and mechanism ... inhibitor of p97, a critical enzyme that controls various ...
(Date:4/16/2015)... British Columbia and MENLO PARK, ... Pharmaceuticals, Inc. (OTCQX: DMPI) (DelMar and the Company), ... cancer therapies in new orphan drug indications, today announced ... been added as a clinical trial site for the ... with refractory glioblastoma multiforme (GBM), the most common and ...
Breaking Biology Technology:The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Bioenterprise Corporation Expands into the Maritimes 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 2DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 4DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 5
... Produces Isobutene From... -- EVRY, France, October 6, 2010 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... 6, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Knowing how to build nanosized assemblies of polymers (long ... range of industrial processes, from the production of nanofibers, ... nanoscale circuits and devices. A recent paper in ... polymers in specially engineered confined spaces, opening the door ...
Cached Biology Technology:Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 2Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 3Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 4Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 5Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 6Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 2Elsevier Introduces Article-Based Publishing to Increase Publication Speed 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 4Elsevier Introduces Article-Based Publishing to Increase Publication Speed 5Elsevier Introduces Article-Based Publishing to Increase Publication Speed 6Elsevier Introduces Article-Based Publishing to Increase Publication Speed 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 8Building a smaller, lighter future: Understanding polymer behaviors below 1 nanometer 2
...
Mouse monoclonal [H4B4] to LAMP2 - Lysosome Marker (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 3920 SwissProtID: P13473...
Mouse monoclonal [IA-C6] to MHC Class II I Ab + Ad (FITC) ( Abpromise for all tested applications). Antigen: Tissue / cell preparation of Purified Mouse lymph node B cells...
...
Biology Products: