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Study helps explain how allergic reactions are triggered
Date:1/14/2008

knockouts were not able to take in calcium, and therefore, were unable to provoke allergic responses when they were exposed to allergens.

These findings provide the genetic demonstration that CRAC channels are essential in mast-cell activation, notes senior author Jean-Pierre Kinet, MD, BIDMC Professor of Pathology at Harvard Medical School. This provides the proof of concept that an inhibitor of the CRAC channel should be able to impact mast-cell related diseases, including asthma and allergic diseases.

Adds Vig, Since mast cells are also known to contribute to the progression of several other debilitating diseases, including multiple sclerosis, rheumatoid arthritis and cancer, an inhibitor of the CRAC channel could, in the future, help in slowing the progression of these diseases as well as alleviate disease symptoms.


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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