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Study helps explain connection between sleep apnea, stroke and death
Date:1/6/2009

ate of health but without sleep apnea.

"After we found that sleep apnea is a risk factor for stroke and death, independent of other risk factors, we hypothesized that there must be something wrong with the regulation of blood flow to the brain," Dr. Mohsenin said. Participants included people with severe sleep apnea who experienced more than 30 apneas an hour during sleep time. The participants were about 47 years old, were free of cardiac disease and had not experienced any strokes. The study also included a control group which did not have sleep apnea but was similar in most other ways.

The researchers monitored the participants' blood pressure while standing and squatting. Standing from a squatting position lowers blood pressure as can be experienced during normal daily activity. They also monitored the participants as they slept. The study found that the sleep apnea group:

  • had lower cerebral blood flow velocity
  • had significantly lower blood oxygen levels during sleep
  • took longer to recover from a drop in blood pressure
  • took longer to normalize blood flow to the brain

Identification is key

Overall, the findings indicate that repeated surges and drops in blood pressure and low oxygen levels eventually impair the body's ability to regulate blood flow to the brain. Sleep apnea may occur over a long period of time before the person becomes aware of it and seeks medical treatment. Here are the symptoms Dr. Mohsenin says to watch out for:

  • After eight hours of sleep, you don't feel rested. During the day, you feel more and more tired, and by afternoon, you want to nap.
  • You experience loud, habitual snoring that disturbs others.
  • Your bed partner observes pauses in your breathing.

The treatment of obstructive sleep apnea with an airway pressurization mask has been shown to normalize cerebral autoregulation, although there are not yet any studies to show
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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

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