Navigation Links
Study first to pinpoint why analgesic drugs may be less potent in females than in males
Date:12/23/2008

ATLANTA -- Investigators at Georgia State University's Neuroscience Institute and Center for Behavioral Neuroscience are the first to identify the most likely reason analgesic drug treatment is usually less potent in females than males. This discovery is a major step toward finding more effective treatments for females suffering from persistent pain.

"Opioid-based narcotics (such as morphine) are the most widely prescribed therapeutic agents for the alleviation of persistent pain; however, it is becoming increasingly clear that morphine is significantly less potent in women compared with men. Until now, the mechanism driving the phenomenon was unknown," said Anne Murphy, Ph.D., a Georgia State Professor of Neuroscience and member of the Center for Behavioral Neuroscience, who conducted the research with Dayna Loyd, Ph.D.

Murphy recently solved the mystery with findings printed in the December issue of The Journal of Neuroscience that show that previously reported differences in morphine's ability to block pain in male versus female rats are most likely due to sex differences in mu-opioid receptor expression in a region of the brain called the periaqueductal gray area (PAG).

Located in the midbrain area, the PAG plays a major role in the modulation of pain by housing a large population of mu-opioid receptor expressing neurons. Morphine and similar drugs bind to these mu-opioid receptors analogous to a 'lock and key' and, ultimately, tell the brain to stop responding to pain signals to the nerve cells resulting in the reduced sensation of pain.

Using a series of anatomical and behavioral tests, Murphy and Loyd were able to determine that male rats have a significantly higher level of mu-opioid receptors in the PAG region of the brain compared with females. This higher level of receptors is what makes morphine more potent in males because less drug is required to activate enough receptors to reduce the experience of pai
'/>"/>

Contact: Martha Barker Koontz
mbarker@gsu.edu
404-413-5464
Georgia State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study links ecosystem changes in temperate lakes to climate warming
2. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
3. TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims
4. Scientists study how asbestos fibers trigger cancer in human cells
5. Male dinosaurs may have been prehistoric babysitters, study shows
6. Study: Did early climate impact divert a new glacial age?
7. Purdue study suggests warmer temperatures could lead to a boom in corn pests
8. Study links ecosystem changes in temperate lakes to climate warming
9. Study of placenta unexpectedly leads to cancer gene
10. New study pardons the misunderstood egg
11. Ocean fish farming harms wild fish, study says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... songbirds are disappearing, and though conservationists are examining several ... acid rain and light pollution, a key piece of ... go once they leave their breeding sites, and what ... To answer this question, a team of researchers out ... connectivity map produced for a songbird, using tracking from ...
(Date:7/23/2014)... DC -- The planet,s soil releases about 60 billion ... is far more than that released by burning fossil ... This enormous release of carbon is balanced by carbon ... other plant matter, as well as by the underground ... have documented that rising temperatures increase the rate of ...
(Date:7/23/2014)... in personalized cancer medicine, (the WIN consortium), recently announced ... Jefferson University will be one of its six ... group in the Tri-State Area. The goal of WIN ... to the patient by forging collaborations between partners in ... the WIN consortium means Jefferson cancer patients will have ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2Climate change and the soil 2New partnership brings more personalized cancer treatment to Philadelphia 2
... leave the pediatrician,s office if your child has strep ... treatment. A novel application for applying DNA "nanobarcodes" ... and more accurately determine what,s causing a patient,s acute ... R. Hartman, a Cornell University PhD candidate in Biological ...
... generation sequencing (NGS) and Genomatix Software GmbH, a leading ... data, announce their decision to combine their expertise and ... genome analysis and re-sequencing project services. "We are ... high level of expertise in understanding and interpretation of ...
... New Queen,s University research has shown that the growth of melanoma, ... slowed when a little known gene called MicroRNA 193b is added. ... miR-193b when he discovered that it was deficient in melanoma tumors ... The miRNA-193b gene is found in people,s DNA and was unknown ...
Cached Biology News:Instant testing for sore throats wins CIMIT prize 2Instant testing for sore throats wins CIMIT prize 3Instant testing for sore throats wins CIMIT prize 4
(Date:7/23/2014)... the Vienna University of Technology and the Maria ... perfect semiconductor crystals into a silicon nanowire. With ... fast and multi-functional processing units can be accommodated ... research results will be published in the journal ... the cornerstone of future chip technology, but the ...
(Date:7/23/2014)... 23, 2014  AuraSense Therapeutics, the pioneer in developing ... regulatory and immunotherapeutic agents, announced today that ... Therapeutics, executive leadership team as chief financial ... to joining AuraSense Therapeutics, Mr. Snyder was ... of Cellular Dynamics International Inc., where he ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Last year, ... Systems , a leading global provider of data management ... with TrialMaster, a leading-edge system for electronic data capture ... of universal design and study execution tools added TrialMaster ... and much anticipated version of Transform for TrialMaster, is ...
(Date:7/23/2014)... 23 de julio de 2014 ADB ... Compañía) ha anunciado hoy una asociación con Austen ... (ABIA o el Instituto), para el propósito de ... de terapia de señal bioeléctrica (el E-QURE BST ... Instituto, que tiene una importante experiencia en cicatrización ...
Breaking Biology Technology:A crystal wedding in the nanocosmos 2AuraSense Therapeutics Appoints Biotechnology Veteran David S. Snyder as Chief Financial Officer 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6
... decision last week to merge its Imaging and Printing Group ... Systems Group (IPSG) is a major milestone in HPs journey ... combining these two units, HP has a unified and convincing ... may be the key that turns HPs consumer message into ...
... researchers will show off developments in games that offer real-world ... ,The Academic Advanced Distributed Learning Co-Laboratory , WTN and ... how Games are Shaping Business and Learning, which will center ... applied to the workforce. , ,The video game industry has ...
... Business is booming again at the University of Wisconsin-Madisons ... job-seekers. , ,This is the best hiring situation weve seen ... associate director of ECS . Fall 2004 recruiting was ... are expected to attend Career Connection, the colleges spring job ...
Cached Biology Technology:HP charges toward the living room 2HP charges toward the living room 3Businesses and educators to preview video games for training 2Businesses and educators to preview video games for training 3Companies recruiting more UW engineering students 2Companies recruiting more UW engineering students 3Companies recruiting more UW engineering students 4
Schneider's Drosophila - Insect medium...
... includes protein separation by two-dimensional electrophoresis ... software package from Bio-Rad and protein ... order to meet customers requirements regarding ... and format of the results permanent ...
... Dual-Binary Analytical System more than doubles the ... LC/MS. The fast analysis cycles of the ... to 100% in tandem mode. Difficult separations ... Using backflush or heartcut configurations, on-line sample ...
... a molecular weight of 16 kDa. Leptin is ... by adipocytes [1,2]. Leptin is thought to play ... [1-3]. In the human, leptin levels are elevated ... A relationship between serum leptin levels and several ...
Biology Products: