Navigation Links
Study finds variations in 1 gene may be associated with endurance running
Date:2/18/2010

BETHESDA, Md. (Feb. 16, 2010) A few minor variations in one gene may make a difference in athletic endurance, according to a new study from Physiological Genomics.

The study found that elite endurance athletes were more likely to have variations of the NRF2 gene than elite sprinters. Non-elite endurance athletes were also more likely to have the genetic variations compared to sprinters, although the difference was not as pronounced.

The study shows an association between the gene variation and endurance, but does not establish a cause-effect relationship. Future studies are needed to unravel exactly what role the gene plays in athletic performance. The study is part of a larger body of research that is exploring the human genome and which aims to understand the genetic underpinnings of athletic performance.

Although the human genome is relatively uniform, there are variations among individuals. The researchers investigated the NRF2 gene because previous studies have shown that it may play a role in endurance performance because it:

  • helps produce new mitochondria, a key cellular structure that produces energy
  • reduces the harmful effects of oxidation and inflammation, which increase during exercise

"These findings suggest that harboring this specific genotype might increase the probability of being an endurance athlete," said one of the authors, Nir Eynon of Wingate Institute in Israel. The study, "Interaction between SNPs in the NRF2 gene and elite endurance performance," was carried out by Dr. Eynon, Alberto Jorge Alves, Moran Sagiv, Chen Yamin, Prof. Michael Sagiv and Dr. Yoav Meckel. All are at the Wingate Institute except for Alberto Alves, who is with the University of Porto in Portugal. The American Physiological Society (www.the-APS.org) published the study.

The Study

The study examined 155 track and field athletes who had competed in national or international track and field competitions. The athletes were further subdivided into endurance group (10,000 meter and marathon runners) and a sprint group (100- and 200-meter and long jump). The control group consisted of 240 non-athletic healthy individuals.

These groups were further divided into elite-level (those who had represented Israel in the world track and field championships or in the Olympics) and national-level (those who had competed in national competitions, but not international).

The study found that two variations in the NRF2 gene (specifically, the NRF2 A allele and the NRF2 C/T genotype) occurred more often in endurance athletes than in sprinters. "Eighty percent of the elite-level endurance athletes were carrying the A allele of the NRF2 A/C single nucleotide protein, compared to only 46% of the elite-level sprinters," Nir. Eynon said. The study also found that the combined NRF2 AA+ NRF2 C/T genotype was more frequent in endurance athletes than in the sprinters group and the control group.

"So," concludes Eynon, "some of us are truly born to run."


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: