Navigation Links
Study finds surprising benefits about diary cow inflammation
Date:7/12/2013

MANHATTAN, Kan. -- Inflammation. The word typically has a negative connotation. Arthritis infection numerous maladies come to mind.

But a Kansas State University researcher found that inflammation that occurs naturally in dairy cows the first few days after giving birth may play a surprisingly beneficial role in the complex process of going from late pregnancy to lactation.

"We know that during the first several days after giving birth and going into the lactating phase, dairy cows naturally experience some degree of inflammation," said Barry Bradford, associate professor in the university's department of animal sciences and industry. "We also know that many disorders, including metabolic diseases such as ketosis and fatty liver, occur during this time of transition."

He, along with a team of researchers from Kansas State University, Iowa State University and Michigan State University, wondered if inflammation actually causes the metabolic problems.

Thinking that reducing inflammation during this period might be beneficial for the cow's transition from gestation to lactation, plus limit metabolic disease, Bradford and the team conducted a study. The objective was to determine if using an anti-inflammatory drug (sodium salicylate or SS) for the first seven days of lactation would prevent liver fat accumulation, improve the supply of glucose for lactation, and limit metabolic disease in dairy cows entering lactation. SS was delivered to the animals in a controlled way to their drinking water.

The team did not get the result they expected.

"Our findings suggest that mild inflammation may be a necessary part of a cow's adaptation to lactation," Bradford said.

Among the significant findings, the research showed that rather than preventing fatty liver by blocking the inflammation, liver fat content was actually increased in the first week of lactation. Similarly, anti-inflammatory treatment led to a dramatic drop in plasma glucose concentration in mature cows. Both of these responses are often associated with metabolic disease in early lactation cows.

"The study improved our understanding of the re-prioritization process by suggesting that inflammatory pathways promote a temporary state of insulin resistance in dairy cows, resulting in conservation of glucose for use by the mammary gland," Bradford said.

The results of the study, which was funded by the U.S. Department of Agriculture's National Institute of Food and Agriculture, indicate that inflammation-induced insulin resistance is in some cases an adaptive, rather than pathological, phenomenon. It may help clarify why the links between inflammation and metabolism have survived the evolution process, he said.

And it's not just cattle that experience the shift in demands on the body: "Many species experience these dramatic shifts," Bradford said. "The role of inflammation in this process has not been studied very much. We are missing some information about why our bodies are wired the way they are even after evolutionary refinement of the immune system, there seems to be a role for inflammation in metabolic function."

The research team's findings have been published by the American Journal of Physiology.

"Our findings suggest that we want some degree of inflammation at this time because it helps the animal shift gears," Bradford said. "Rather than thinking of mild inflammation as a disease-inducing factor, we think there may be times during life where some inflammation is advantageous or necessary."

The research team plans to delve into the topic further and is seeking funding to find evidence of the phenomenon in other species.


'/>"/>

Contact: Barry Bradford
bbradfor@k-state.edu
785-532-7974
Kansas State University
Source:Eurekalert

Related biology news :

1. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
2. Journal highlights Arctic sea ice study by UM professor
3. Innovative MIT study estimates extent to which air pollution in China shortens human lives
4. Temperature increases causing tropical forests to blossom, according to study
5. New study reveals important role of insulin in making breast milk
6. Study reveals ancient jigsaw puzzle of past supercontinent
7. Reproductive BioMedicine Online publishes study on assisted reproduction
8. Lifesaving HIV treatment could reach millions more people following landmark study
9. Low levels of toxic proteins linked to brain diseases, study suggests
10. UT study: Chemical in antibacterial soaps may harm nursing babies
11. Aerial mosquito spraying study finds no immediate public health risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/13/2017)... India , April 13, 2017 According to ... Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, ... MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 Billion ... Growth Rate (CAGR) of 17.3%. ... MarketsandMarkets ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Tunnell Consulting announced today that four ... ISPE Annual Meeting and Expo , to be held October 29 through November 1 ... “Driving innovation to advance patient therapies.” , The ISPE Annual Meeting and Expo will ...
(Date:8/16/2017)... PA (PRWEB) , ... August 16, 2017 , ... While ... they are much more closely connected than one might think. A Mesh Is ... will open at the University City Science Center’s Esther Klein Gallery (EKG) on August ...
(Date:8/16/2017)... -- This year,s edition of the Inc. 5000 features a now-familiar name: BioPoint ... made the list for the third year in a row. Now in ... based on a set of quantitative metrics. In addition, BioPoint was also ... the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kapstone Medical is proud ... successes helping medical technology companies and inventors develop and safeguard their latest innovations. ... engineering firm with a portfolio of clients in the United States and around the ...
Breaking Biology Technology: