Navigation Links
Study finds strong genetic component to childhood obesity
Date:3/26/2013

Previous research has shown that obesity runs in families, and twin studies suggest that this is largely due to genetic factors, with heritability estimates over 50%. 32 genes have been identified as risk factors for obesity but previous analyses suggest that these genes alone cannot fully explain the high level of heritability in childhood obesity, as together they explain only 2% of individual differences in childhood body weight. This has led to a problem of 'missing heritability'.

In this study, researchers used a new method called Genome-wide Complex Trait Analysis (GCTA), to investigate the molecular genetic heritability of body weight in children. GCTA takes advantage of the fact that some people are more genetically similar to one another than others, by chance; and looks to see whether individuals who just happen to be more genetically similar might also be more similar in weight. Using this approach, GCTA estimates the combined effects of all known common genes across the whole genome, associated with childhood body weight.

The study is based on data from a population-based cohort of 2,269 children aged between eight and eleven years old. Researchers looked at whether children who happen to be more genetically similar might also be more similar in body weight. Using the GCTA method, the researchers found that additive effects of multiple genes across the whole genome accounted for 30% of individual difference in childhood body weight.

Clare Llewellyn from UCL Health Behaviour Research Centre and lead author of the study, said: "These findings are important because they confirm that in children genes play a very important role in determining body weight. At present only a few genetic variants have been discovered, and these explain a very small amount of individual differences in body weight (~2%). These findings suggest there are hundreds of other genetic variants influencing body weight that are yet to be discovered".

This study underlines the importance of genetic effects in childhood obesity, supporting the current thinking that children of obese parents are most at risk of becoming obese.


'/>"/>

Contact: Rosie Waldron
r.waldron@ucl.ac.uk
020-767-99041
University College London
Source:Eurekalert

Related biology news :

1. Einstein study reveals new approach for stopping herpes infections
2. New lung cancer study takes page from Googles playbook
3. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
4. Scientists awarded £3M to study the way Northwest European seas absorb carbon
5. Additional research must be done to ensure safety of pit latrines, new study says
6. UF fossil bird study on extinction patterns could help todays conservation efforts
7. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
8. Study explores long-term water quality trends in near-pristine streams
9. New study highlights strong anti-cancer properties of soybeans
10. High-carb intake in infancy has lifelong effects, UB study finds
11. Cell Transplantation study finds stem cells in deer antler
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... Alisa Wright, ... Distinguished Alumni Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , ... Pharmacy Program for achievements in their careers and other scientific endeavors. , Wright ...
(Date:4/19/2017)... ... April 19, 2017 , ... ThermaGenix, the PCR ... event adds to several other early achievements at ThermaGenix, including the business formation ... , ThermaGenix will use proceeds from the Series A-1 round to:, ...
(Date:4/19/2017)... PUNE, India , April 19, 2017 A ... Opportunity Analysis and Industry Forecast, 2014-2022 ," the global market was valued at ... registering a CAGR of 9.6% from 2016 to 2022. ... ...      (Logo: ...
(Date:4/19/2017)... April 19, 2017 Veracyte, Inc. ... that it will report its first quarter 2017 ... 3, 2017. Following the announcement, Veracyte,s management will host a ... Time to discuss the company,s financial results and business ... replay may be accessed by visiting Veracyte,s website at  http://investor.veracyte.com ...
Breaking Biology Technology: