Navigation Links
Study finds strong genetic component to childhood obesity
Date:3/26/2013

Previous research has shown that obesity runs in families, and twin studies suggest that this is largely due to genetic factors, with heritability estimates over 50%. 32 genes have been identified as risk factors for obesity but previous analyses suggest that these genes alone cannot fully explain the high level of heritability in childhood obesity, as together they explain only 2% of individual differences in childhood body weight. This has led to a problem of 'missing heritability'.

In this study, researchers used a new method called Genome-wide Complex Trait Analysis (GCTA), to investigate the molecular genetic heritability of body weight in children. GCTA takes advantage of the fact that some people are more genetically similar to one another than others, by chance; and looks to see whether individuals who just happen to be more genetically similar might also be more similar in weight. Using this approach, GCTA estimates the combined effects of all known common genes across the whole genome, associated with childhood body weight.

The study is based on data from a population-based cohort of 2,269 children aged between eight and eleven years old. Researchers looked at whether children who happen to be more genetically similar might also be more similar in body weight. Using the GCTA method, the researchers found that additive effects of multiple genes across the whole genome accounted for 30% of individual difference in childhood body weight.

Clare Llewellyn from UCL Health Behaviour Research Centre and lead author of the study, said: "These findings are important because they confirm that in children genes play a very important role in determining body weight. At present only a few genetic variants have been discovered, and these explain a very small amount of individual differences in body weight (~2%). These findings suggest there are hundreds of other genetic variants influencing body weight that are yet to be discovered".

This study underlines the importance of genetic effects in childhood obesity, supporting the current thinking that children of obese parents are most at risk of becoming obese.


'/>"/>

Contact: Rosie Waldron
r.waldron@ucl.ac.uk
020-767-99041
University College London
Source:Eurekalert

Related biology news :

1. Einstein study reveals new approach for stopping herpes infections
2. New lung cancer study takes page from Googles playbook
3. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
4. Scientists awarded £3M to study the way Northwest European seas absorb carbon
5. Additional research must be done to ensure safety of pit latrines, new study says
6. UF fossil bird study on extinction patterns could help todays conservation efforts
7. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
8. Study explores long-term water quality trends in near-pristine streams
9. New study highlights strong anti-cancer properties of soybeans
10. High-carb intake in infancy has lifelong effects, UB study finds
11. Cell Transplantation study finds stem cells in deer antler
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)...  The American College of Medical Genetics and Genomics was ... as one of the fastest-growing trade shows during the Fastest ... in Las Vegas . ... in each of the following categories: net square feet of ... attendees. The 2015 ACMG Annual Meeting was ranked 23 out ...
(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Mount Laurel, NJ (PRWEB) , ... December 06, ... ... a white paper on December 1, 2016 asking the Federal Drug Administration (FDA) ... to the study of OA, OARSI is concerned about the growing population of ...
(Date:12/6/2016)... According to a new market research report "Microfluidics Market ... (Genomics, Proteomics, Capillary Electrophoresis, POC, Clinical, Environmental, Drug Delivery) - Global ... to reach USD 8.78 Billion by 2021 from USD 3.65 Billion ... (2016 to 2021). Continue Reading ... ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... a company focused on discovery and development of precision treatments for neurodegenerative ... developing for Alzheimer’s disease (AD) inhibited the direct neurotoxic effect of prion-like ...
(Date:12/5/2016)... ... December 05, 2016 , ... The Real Dirt with Chip ... technology and application experts, Chip Baker. Chip Baker formerly co-founded Royal Gold Soil ... 30 years, Chip Baker other industry veterans have made the evolution of cannabis ...
Breaking Biology Technology: