Navigation Links
Study finds potential to match tumors with known cancer drugs
Date:2/5/2013

n the journal Cancer Discovery.

In breast cancer, the researchers spotted outlier expression of ERBB2 kinase in HER2-positive tumors, which would be expected. HER2-positive tumors can be treated with Herceptin. But they also found another kinase, called FGFR4 and they found that adding a drug that blocks FGFR4, in combination with Herceptin, improved the anti-cancer effect. This was done only in cells in the laboratory, but the FGFR4-inhibitor continued to be effective in cells even after they became resistant to Herceptin.

In the pancreatic cancer samples, the researchers found several different kinases that have drugs that work against them, including MET, AKT and PLK. Pancreatic cancer is one of the most deadly types of cancer, often diagnosed in its late stages when treatments are not very effective. The main driver of pancreatic cancer, a mutation in a gene called KRAS, has proven difficult to target with treatments.

In the lab, researchers blocked the outlier kinases and found it had an effect against the cancer cells. They then blocked KRAS something that can be done in the lab but has not been achieved in patients with pancreatic cancer and found an even larger effect.

"If in the future we could target KRAS in patients and also hit the outlier kinases, it could have a huge impact on treatment of pancreatic cancer," Kumar-Sinha says.

These findings must still be tested in patients, but researchers are hopeful that targeting specific kinases expressed in an individual patient's tumor could make a difference.

The U-M Comprehensive Cancer Center is currently using gene sequencing techniques to help match advanced cancer patients with potential clinical trial opportunities based on the make-up of their tumor.

"We hope kinases will represent another available avenue with whole genome sequencing. If we can identify rational multiple targets for treatment, it's more effective. This gets us one
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Can plants be altruistic? You bet, says new CU-Boulder-led study
2. New study sheds light on link between dairy intake and bone health
3. Medical societies to launch large-scale study on vein filter use
4. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
5. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
6. New Geology study raises questions about long-held theories of human evolution
7. New study highlights impact of environmental change on older people
8. UNC study may lead to treatments that are effective against all MRSA strains
9. Aztec conquest altered genetics among early Mexico inhabitants, new DNA study shows
10. Study reveals significance of second trimester markers for Downs syndrome
11. Scripps Research Institute study shows how brain cells shape temperature preferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... years old give unprecedented insight into the evolutionary ... most species-rich groups among the modern bony fishes. ... from the Division of Paleontology and Geobiology at ... Ludwig-Maximilians-Universitaet (LMU) in Munich / Germany have completed ... assign to the group of bony fishes that ...
(Date:5/16/2013)... Cameroon and the manager of San Diego Zoo Global,s ... Whitley award. The Whitley award is an international ... it celebrates the extraordinary achievements of some of the ... was selected for the award due to his efforts ... its wildlife inhabitants., HRH The Princess Royal, the charity,s ...
(Date:5/15/2013)... studies touting its benefit in moderating gout risk, new ... does not reduce uric acid (urate) levels to a ... C supplementation, alone or in combination with allopurinol, appears ... levels in gout patients according to the results published ... Arthritis & Rheumatism . , Gout is an ...
Breaking Biology News(10 mins):Paleontology: The eloquence of the otoliths 2Paleontology: The eloquence of the otoliths 3Cameroon researcher wins prestigious 'Green Oscar' 2Cameroon researcher wins prestigious 'Green Oscar' 3Vitamin C does not lower uric acid levels in gout patients 2
... Academies today announced the recipients of their 2009 Communication ... INITIATIVE, these prestigious awards recognize excellence in reporting and ... With support from the W.M. Keck Foundation, the ... This year,s winners will be honored during a ...
... Boston, with the Broad Institute and Harvard Medical School, ... National Institute of Mental Health as part of the ... with autism, using new technologies for rapid DNA sequencing ... grant, part of the federal stimulus package, officially starts ...
... of Massachusetts Medical School today announced the beginning of ... activity of a human monoclonal antibody (MAB) developed to ... being conducted at the King Edward Memorial Hospital in ... of India, which is working in a collaborative partnership ...
Cached Biology News:Academies announce winners of 2009 Communication Awards 2Academies announce winners of 2009 Communication Awards 3Stimulus grant to fund whole-genome sequencing in children with autism 2Stimulus grant to fund whole-genome sequencing in children with autism 3First human gets new antibody aimed at rabies virus 2First human gets new antibody aimed at rabies virus 3
(Date:5/16/2013)... DIEGO , May 16, 2013  The registration ... of Bioscience Financial Officers (ABFO) 2013 National Conference, the ... be held May 28-31 at the Hilton San Diego ... touches on this year,s conference and want to make ... to attend," said Brandi Roberts , ...
(Date:5/16/2013)... May 16, 2013 As the weather warms, ... their favorite Spring looks. While most make a statement with ... many women find the warmer weather mixes makeup and sweat ... with the onset of acne during warmer months, Adult ... acne treatment users the best ways to deter breakouts. ...
(Date:5/16/2013)... NEW YORK , May 16, ... a new market research report is ...   Competitor Analysis: ... Biosuperiors http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical ...   The ...
(Date:5/16/2013)... 2013 BioInformatics LLC New Market Report ... Cell-Derived Cells: Current and Future Opportunities (13-004) , ... in the primary cells market continues to increase. In ... used most often, how satisfied scientists are with commercially ... anticipated growth rate. ,  , Additionally, terminally differentiated ...
Breaking Biology Technology:Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 3Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 4Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 2BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 3
... - Johnson & Johnson Diabetes Institute Launched ... Key Role in Halting Escalating,Disease in the EMEA ... the number of people with diabetes,will have increased ... within Eastern,Mediterranean and Middle Eastern populations and 80 ...
... Sept. 24 InVitria,( http://www.InVitria.com ) addressed ... Cell Culture Development" Conference on,September 15-16 in ... optimizing cell culture media using its product ... ), In a presentation of scientific ...
... (Nasdaq: MATK ) --,Martek Biosciences Corporation ... sole source supply agreement with Grupo Ricap. Martek ... produced by Grupo Ricap in,Mexico. Grupo Ricap is ... & life,sARA(TM) will initially be available in infant,formula ...
Cached Biology Technology:Health Experts Call for New Strategies to Combat Alarming Rise in Diabetes 2Health Experts Call for New Strategies to Combat Alarming Rise in Diabetes 3Health Experts Call for New Strategies to Combat Alarming Rise in Diabetes 4InVitria Touts Product Advantages at Cambridge's Cell Culture Conference 2Martek to be the Sole Source Supplier of DHA and ARA for Infant Formulas Produced By Grupo Ricap 2
For testing the AQUA technique on your MS instruments....
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
A formulation of our Biolase DNA Polymerase which contains a Red Loading Dye...
... assay (ELISA) test kits are qualitative ... the detection of drugs and/or their metabolites ... for forensic use only. It is recommended ... a quantitative method such as GC/MS. ...
Biology Products: