Navigation Links
Study finds potential to match tumors with known cancer drugs
Date:2/5/2013

ANN ARBOR, Mich. When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.

Now in a new study, University of Michigan Comprehensive Cancer Center researchers assess the complete landscape of a cancer's "kinome" expression and determine which kinases are acting up in a particular tumor. They go on to show that those particular kinases can be targeted with drugs potentially combining multiple drugs to target multiple kinases.

"We have a small but effective inventory of 'druggable' mutations that we know play a role in cancer. As we are doing more sequencing, we're coming to realize just how small that inventory is. On the one hand, it's a limitation. On the other hand, there are numerous oncogenic kinases, and there are a lot of kinase inhibitors. Our goal is to determine how to match more of these therapies with the right patients," says senior study author Chandan Kumar-Sinha, Ph.D., research assistant professor at the Michigan Center for Translational Pathology.

The researchers looked at RNA sequencing data from 482 samples of both cancerous and non-cancerous tissue and identified the most highly expressed kinases in individual breast cancer and pancreatic cancer samples. They found certain common themes.

"A lot of samples showed one or two kinases that showed an outstandingly high 'outlier' expression," says Kumar-Sinha. It wasn't that the researchers always found a mutation just that one or more kinases were expressed at a far higher level than all other kinases.

"We don't always know what's causing it to be overexpressed. But since it's there, we know that somehow the high expression of oncogenic kinases is advantageous to the cancer, and so we can therapeutically exploit that dependency," Kumar-Sinha says.

Results of the study appear online i
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Can plants be altruistic? You bet, says new CU-Boulder-led study
2. New study sheds light on link between dairy intake and bone health
3. Medical societies to launch large-scale study on vein filter use
4. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
5. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
6. New Geology study raises questions about long-held theories of human evolution
7. New study highlights impact of environmental change on older people
8. UNC study may lead to treatments that are effective against all MRSA strains
9. Aztec conquest altered genetics among early Mexico inhabitants, new DNA study shows
10. Study reveals significance of second trimester markers for Downs syndrome
11. Scripps Research Institute study shows how brain cells shape temperature preferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... One of the most diverse families in the ... (or lucinids) -- originated more than 400 million years ... habits like those of its modern members. This ... of Hawaii, published online on 25 July 2014, tracks ... symbiotic relationships. , At is origin, the Lucinidae family ...
(Date:8/1/2014)... new study, including two Simon Fraser University research ... and policymakers must collaborate closely on minimizing damage ... Viorel Popescu and Maureen Ryan, David H. Smith ... are among eight international co-authors of the newly ... the Environment . , Shale gas development is ...
(Date:7/31/2014)... research, supported by the National Science Foundation (NSF), ... uniformly accelerates atmospheric warming, indicating instead that certain ... emit into the atmosphere. , The study, ... , focuses on thermokarst lakes, which occur as ... with melted fresh water, converting what was previously ...
Breaking Biology News(10 mins):Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3Certain Arctic lakes store more greenhouse gases than they release 2
... originality and excellence by rewarding outstanding young scientists, the ... Sciences was awarded to Prof. Martin T. Zanni of ... developing research tools for the study of complex bio-molecules, ... for his work in the field of energy transfer. ...
... Smithsonian Conservation Biology Institute and partnering organizations will build ... and embryonic cells. Genetic banks composed of frozen biomaterials ... conservation of species and genetic variation. Because the banked ... one, 50 or, in theory, even 1,000 years from ...
... University] When you suffer a heart attack, a part ... wall and a special class of cells that spontaneously expand ... are lost forever. Surgeons can,t repair the affected area. ... potholes, you abandon what,s there and build a new road ...
Cached Biology News:Tel Aviv University's Sackler Prizes awarded to 2 North American chemists 2Smithsonian to help create frozen repository for the Great Barrier Reef 2Researchers create nanopatch for the heart 2
(Date:8/1/2014)... 01, 2014 Chantel Lee ’15 and Eli ... 10 40-hour weeks with Dr. Juan Rodriguez, Professor of Physics, ... a common diabetic eye disease caused by changes in the ... and Eli accomplished is quite remarkable,” said Rodriguez. “They took ... when they started, and together carried it to near completion ...
(Date:8/1/2014)... CHICAGO , Aug. 1. 2014 As ... U.S., the 2014 AACC Annual Meeting & Clinical Lab ... testing and patient care are introduced to the healthcare ... by the Expo,s 650 exhibitors will include the latest ... Advances in smartphones and biosensors have enabled ...
(Date:8/1/2014)... Research and Markets has announced ... (SNP) Genotyping and Analysis Market 2014-2018" report to ... Single Nucleotide Polymorphism (SNP) genotyping is the ... the genome of various species. SNPs are commonly present ... technology can analyze thousands of SNPs and has the ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 Testing ... led to a better understanding embryonic development. ... reorganize into structurally and functionally distinct tissues is ... defects. Prof. Todd McDevitt, Melissa Kinney, and ... signals interact with biochemical cues to control many ...
Breaking Biology Technology:Two Centenary College Students Tackle Diabetic Retinopathy Research 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2Study Links Biomechanics and Gene Expression in Stem Cells 2
... Reportlinker.com announces that a new market ... Case Study: Personalized Cancer ... and companion diagnostic co-development ... The treatment of cancer ...
... Madison, Wis. If you,ve ever lost your keys or stuck ... you may have been the victim of a tired brain region ... of Wisconsin-Madison have a new explanation.,They,ve found that some nerve cells ... into a sleep-like state, while the rest of the brain appears ...
... have created a new kind of cloaking material ... range. Though this design can,t translate into ... could have implications in diagnostics, security, and communication. ... professor of mechanical engineering at Northwestern,s McCormick School ...
Cached Biology Technology:Reportlinker Adds Case Study: Personalized Cancer Therapy - The era of biomarker identification and companion diagnostic co-development 2Reportlinker Adds Case Study: Personalized Cancer Therapy - The era of biomarker identification and companion diagnostic co-development 3Brain regions can take short naps during wakefulness, leading to errors 2Researchers create terahertz invisibility cloak 2
... (4) ,human IgG subclass 1 100% ,human IgG ... 100% ,human IgG subclass 4 ... 100% ,human IgG Fc ... 0.04% ,human IgG Fab ...
Human VEGF R2 (KDR) MAb (Clone 89106)...
Salmonella typhimurium Immunogen: Heat inactivated bacterial cells of Salmonella typhimurium B Storage: 4 C...
...
Biology Products: