Navigation Links
Study finds novel genetic risk factors for kidney disease
Date:5/10/2009

A team of researchers from the United States, the Netherlands and Iceland has identified three genes containing common mutations that are associated with altered kidney disease risk. One of the discovered genes, the UMOD gene, produces Tamm-Horsfall protein, the most common protein in the urine of healthy individuals. Although the Tamm-Horsfall protein has been known for almost 60 years, its functions are not well understood and its relationship to chronic kidney disease risk was not known previously. The findings are published in the May 10 issue of Nature Genetics.

More than 20 million adults in the United States have chronic kidney disease characterized by reduced kidney function or kidney damage. The progression of chronic kidney disease can lead to kidney failure and the need for dialysis or transplantation. In addition, chronic kidney disease increases the risk of cardiovascular diseases, mortality and medication side-effects. Known risk factors for chronic kidney disease include hypertension and diabetes.

The research team conducted genome wide association studies of more than 20,000 people enrolled in four large population-based studies of cardiovascular disease risk factors: Atherosclerosis Risk in Communities (ARIC) Study, the Cardiovascular Health Study, the Framingham Heart Study and the Rotterdam Study. They further replicated their findings in another 20,000 participants. Of more than 2,500,000 genetic variants that were evaluated for each study participant, the researchers found strong statistical evidence supporting three genes, UMOD, SHROOM3, and STC1 as novel risk genes for reduced kidney function and chronic kidney disease.

"Previous research showed that rare mutations in the UMOD gene cause hereditary forms of severe kidney disease. Our research indicates that a common genetic variant with a frequency of 18 percent in populations of European ancestry is associated with about 25 percent lower risk of chronic
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... started in 2000 as an EC-FP5 four-year project, delivering ... steady progress and successful participations in several EC projects, ... Observation Network project (EU BON), to increase the ... and to extend the general dissemination of the Fauna ... has applied its novel e-Publishing tools to prepare ...
(Date:9/17/2014)... from the Copenhagen Centre for Social Evolution and Yale ... that birth weight and -length can partially predict the ... as autism and schizophrenia later in life. The study ... subsequent hospital diagnoses for up to 30 years, and ... study is published today in the Proceedings of ...
(Date:9/17/2014)... Mich. Mutations in the human retinoblastoma protein gene ... State University scientists have turned to fruit fly eyes ... , In a paper featured on the cover ... Biological Chemistry , Michigan State University researchers provide the ... to those present in the human cancer gene, said ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Abnormal properties of cancer protein revealed in fly eyes 2
... farmers in Riau province, Sumatra, have been blamed for ... Malaysia. But scientists in Indonesia have added a third ... to land for oil palm and clear it by ... World Agroforestry Centre, who have been studying land conversion ...
... in Belgium has shown that low-cost IVF for ... effective, with delivery rates not much different from ... study, say the investigators, suggests that infertility care ... IVF methodology can be significantly simplified and result ...
... enough milk to breastfeed? A new study by scientists ... California Davis adds to their previous research implicating insulin,s role ... describe how the human mammary gland becomes highly sensitive to ... to get an accurate picture of how specific genes are ...
Cached Biology News:Less haze in Singapore as the cause becomes clearer and more complex 2IVF for 200 euro per cycle 2IVF for 200 euro per cycle 3New study reveals important role of insulin in making breast milk 2New study reveals important role of insulin in making breast milk 3
(Date:9/17/2014)... MESSENGER has just celebrated its 10 year anniversary in ... of its latch valves, V27200-818, operating onboard this spacecraft. ... the planet Mercury. It is only the second spacecraft ... vast amount of information and images of the planet. ... that also include permanent magnets to maintain the valve ...
(Date:9/16/2014)... -- This report analyzes the worldwide markets for Bioinformatics in ... Biocontent. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2013 ... these markets. Market data and analytics are derived from primary ...
(Date:9/16/2014)... COLUMBIA, Mo. From cell phones to cars ... everyday life. Scientists and technology companies constantly are ... Now, for the first time using a water-based ... created a long-lasting and more efficient nuclear battery ... as a reliable energy source in automobiles and ...
(Date:9/16/2014)...  Donald Fresne, President and CEO of Egenix, Inc. is ... PhD to its Scientific Advisory Committee. Dr. Vagner, ... , performed research at Embl (European Molecular Biology Laboratory) ... French institute of health and medical research. He is a ... Institute, Orsay, France , and at the ...
Breaking Biology Technology:Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2
... cites Dr. Lanza for ,Courage Under Fire, ... (OTC Bulletin Board: ACTC) is proud to announced ... Research and Scientific,Development, has been recognized for his ... in the current issue of PharmaVOICE (cover,story July/August ...
... New USA Subsidiary Meets Demand for SLIM Search(TM) ... Aug. 21 Supporting the growing,demand for its ... Ltd. announces the opening of its new sales, ... Mission Viejo,California. SLIM Search, Inc. is the leading ...
... LOUIS, Aug. 20 The MattsonJack Group, Inc.,(MattsonJack), ... Dhawan M.D.,M.B.A., M.P.H. to Medical Director for MattsonJack. ... joined MattsonJack in September 2000 as a consultant ... M.B.A. from the,University of Missouri -- Kansas City. ...
Cached Biology Technology:Advanced Cell Technology's Dr. Robert Lanza Makes List of '100 Most Inspiring People in the Life-Sciences Industry' 2Advanced Cell Technology's Dr. Robert Lanza Makes List of '100 Most Inspiring People in the Life-Sciences Industry' 3Cartesian Gridspeed Opens Subsidiary Operation in North America 2Cartesian Gridspeed Opens Subsidiary Operation in North America 3Dr. Amit Dhawan Promoted to Medical Director for The Mattson Jack Group 2Dr. Amit Dhawan Promoted to Medical Director for The Mattson Jack Group 3
Sheep polyclonal to Salmonella Thomasville ( Abpromise for all tested applications). Antigen: Native Salmonella thomasville...
anti-achaete...
... Rabbit polyclonal to Oct6 ( Abpromise for ... Synthetic peptide conjugated to KLH derived from within ... (Note: the amino acid sequence is proprietary) ... Entrez Gene ID: 5453 ...
... Super-Dark, Super-Small! Capture high-resolution chemiluminescent ... Imaging System. High-sensitivity camera is cooled ... and wide dynamic range for high ... time. The light-tight cabinet provides optimum ...
Biology Products: