Navigation Links
Study finds new role for protein in hearing
Date:8/15/2011

University of Iowa scientists have discovered a new role for a protein that is mutated in Usher syndrome, one of the most common forms of deaf-blindness in humans. The findings, which were published Aug. 8 in Nature Neuroscience, may help explain why this mutation causes the most severe form of the condition.

The study suggests that the protein called harmonin, which is known to be involved in sound sensing in the inner ear, may also play a role in the transmission of sound information to the brain.

Hearing starts with the transmission of sound by inner hair cells in the ear. Sound waves cause movement of special structures called stereocilia on the tips of the hair cells. Harmonin is thought to mediate this movement, which then activates the cells and initiates transmission of sound information as electrical and chemical signals to the brain.

"Most of the research until now has concentrated on the input end of the inner hair cells where the sound waves produce motion of the stereocilia," said Amy Lee, Ph.D., senior study author and UI associate professor in the Departments of Molecular Physiology and Biophysics, Otolaryngology-Head and Neck Surgery, and Neurology. "Now we have found a new role for harmonin at the opposite end of these sound-sensing inner hair cells where it appears to control the signal output of the cell."

Lee and colleagues, including UI postdoctoral fellows Frederick Gregory, Ph.D., and Keith Bryan, Ph.D., found that harmonin is important for regulating the number of calcium channels present at the sound-transmitting synapse of inner hair cells.

Studies from other labs have shown that too few or too many calcium channels at the hair cell synapse cause deafness in mice. This means factors that control how many channels are available are likely to be important for normal hearing.

"Harmonin appears to precisely control how many channels are available," Lee said. "What we think is
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- LiveScan ... has agreed to a partnership with Gabriel Health ... fastest growing Certified Nursing Assistant preparatory ... Institute  an exclusive member of Binary,s LiveScan service ... Biometrics will improve its service capabilities by ...
(Date:8/21/2014)... at improving the food intake, health and quality of ... among three projects at the University of Waterloo receiving ... Institutes of Health Research (CIHR). , Professor Heather ... Waterloo, and a Schlegel research chair in nutrition and ... why many Canadians living in long-term care homes are ...
(Date:8/21/2014)... BOSTON -- Nine researchers from Beth Israel ... included in "The World,s Most Influential Scientific Minds ... from Thomson Reuters ScienceWatch, a web resource for science ... scientists recognized as among the most influential "are performing ... to the advancement of their science," according to a ...
Breaking Biology News(10 mins):LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3Grants will fund landmark aging research at Waterloo 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... United Nations Intergovernmental Panel on Climate Change (IPCC) have warned ... achieve a stable climate on our planet by the end ... coming decades must be curbed before the emissions can be ... CO2 emissions that can be tolerated globally by the end ...
... genetically modified crops, according to new research funded by ... A group at the Open University, led by Professor ... what large-scale, commodity farmers not those mainly involved ... know how consumers, governments and the food industry regard ...
... University of Nottingham could have a major impact on the ... to stay in work. Back pain is one of ... In 2004-5 approximately 34,000 people in the East Midlands suffered ... caused or made worse by their current or past work. ...
Cached Biology News:ETH Zurich competence center ESC introduces energy strategy 2ETH Zurich competence center ESC introduces energy strategy 3What farmers think about GM crops 2Helping back pain sufferers to stay in work 2
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... DUBLIN, Ireland , August 21, 2014 ... and Markets ( http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the ... Market 2014-2018"  report to their offering.  ... also known as hormone therapy, is a ... longer being produced by the body. This ...
(Date:8/21/2014)... 21, 2014 His Majesty Willem-Alexander, King ... The Court of His Majesty Willem-Alexander, King of the ... Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ... , The King will take part in the Grand ... for 11 a.m.-12:20 p.m. and tour the plant. POET-DSM ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
... April 23 ImaRx Therapeutics,Inc. (Nasdaq: IMRX ... an agreement,with Abbott Laboratories pursuant to which it ... promissory note with Abbott issued in,connection with its ... to,the urokinase assets, including the remaining inventory of ...
... PHILADELPHIA, April 23 BioNanomatrix, Inc. today,announced that ... honored at the,14th Annual Ben Franklin Emerging Business ... Management Team category, competing with a,strong group of ... executive officer Dr. Michael Boyce-Jacino accepted the,award on ...
... Calif., April 23 SectorWatch.biz announces the,availability ... news and driving,markets today within the biotechnology ... on the aforementioned equities and the,opportunity for ... on the,subject and sector., Investors can ...
Cached Biology Technology:ImaRx Therapeutics Satisfies Abbott Note Obligation Associated With the Acquisition of Urokinase 2ImaRx Therapeutics Satisfies Abbott Note Obligation Associated With the Acquisition of Urokinase 3BioNanomatrix Named 'Best Management Team' at the 2008 Ben Franklin Emerging Business Awards 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 3
... kits are designed to rapidly and reliably ... patented APA Technology. APAgene provides hassle-free, ready-to ... All necessary ingredients are provided in each ... used for gap filling, localized cloning of ...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
... product is designed to deparaffinize and perform ... fixed paraffin-embedded tissue sections mounted on glass ... the paraffin at the high temperature used ... emulsification of the paraffin by detergent. Formaldehyde ...
Biology Products: