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Study finds missing piece of pediatric cancer puzzle
Date:7/19/2013

Most of the time, it takes decades of accumulating genetic errors for a tumor to develop. While this explains the general occurrence of cancer in adults, it leaves a gap in understanding of the cause of pediatric tumors.

In a study published in the July issue of the Proceedings of the National Academy of Sciences, researchers found a missing piece of the pediatric cancer puzzle. Changxian Shen, PhD, senior research associate at the Center for Childhood Cancer and Blood Diseases at The Research Institute at Nationwide Children's Hospital, and Peter Houghton, PhD, director of the center, may have identified one mechanism behind the early development of some pediatric solid tumors as well as a target for future pediatric cancer therapies.

In healthy cells, a checkpoint prompts the cell to repair damaged DNA before it replicates. Many researchers believe that cancer cells flourish when these checkpoints are skipped or inhibited, as the mutated cells can survive and rapidly reproduce. A growing collection of damaged cells can lead to the solid tumors of many childhood cancers, such as those of rhabdomyosarcoma, neuroblastoma and osteosarcoma.

In their study, Drs. Shen and Houghton found that dampening a particular feedback loop between a repair checkpoint and its controlling pathways may promote the growth of tumors.

"Our prior studies had shown that the DNA damage checkpoint protein, ATM, was very low in most pediatric solid tumors," Dr. Houghton, also a faculty member at The Ohio State University College of Medicine, said. "The question was why?"

The study revealed that a number of problems may be at play in the development of pediatric solid tumors. First, a pathway called mTOR regulates the production of a cancer-causing gene that tells the cell to produce too much of two kinds of microRNAs. These microRNAs, in turn, suppress the synthesis of ATM, which makes it hard for cells to initiate the damage checkpoint
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Contact: Gina Bericchia
gina.bericchia@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

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