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Study finds genetic variant plays role in cleft lip
Date:10/6/2008

as bound to the IRF6 regulatory region.

"Mike Hitchler was able to help Fedik show that the IRF6 gene had a bona fide binding site for the AP2 transcription factor, and that this binding site was disrupted by the genetic variant," said Domann, University of Iowa professor of radiation oncology. "This was very solid evidence for understanding this newly discovered mechanism behind cleft lip.

"It's a great example of what can be achieved when investigators from seemingly disparate fields collaborate and cooperate," Domann added.


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Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
Source:Eurekalert

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