Navigation Links
Study finds genetic links to age of first menstrual period and menopause
Date:5/17/2009

udent in the HSPH Department of Epidemiology while conducting the research. "Insights into the genetic factors influencing the timing of menarche and natural menopause might shed light on normal reproductive function and the prevention of the diseases associated with these two traits."

Daniel Chasman, Director of Computational Biology in the Center for Cardiovascular Disease Prevention at BWH, said: "The collaboration of the WGHS and the NHS represents a great example of how large cohorts with genome-wide data can complement each other. While only one locus reached near genome-wide significance in the NHS alone, the meta-analysis of combined data had much more statistical power and revealed a total of two loci for timing of menarche and four for timing of menopause." Chasman, also an assistant professor at Harvard Medical School, added, "Of the loci for timing of menopause, three were already strong but not proven candidates in the NHS; these loci reached genome-wide significance in the WGHS alone, supplementing the meta-analysis by a second mode of validation through replication. The remaining locus, for timing of menopause, would not have been identified, even as a candidate, without the joint power of these two cohorts working together. Future collaborations will hopefully continue to leverage the combined power of the two cohorts for association studies directed at other clinical characteristics."

The NHS was begun in 1976 to investigate the potential long term consequences of the use of oral contraceptives. The studies were soon expanded to include diet and nutrition, in recognition of their roles in the development of chronic diseases. The research continues today with more than 116,000 women enrolled in the study.

The WGHS was announced in 2006 as a survey of genetic differences among 28,000 initially healthy American women who had already been tracked for over a decade for the development of heart disease, stroke, diabetes, a
'/>"/>

Contact: Christina Roache
croache@hsph.harvard.edu
617-432-6052
Harvard School of Public Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... research at the University of Adelaide has opened the way ... to powdery mildew. , In Australia, annual barley production is ... Powdery mildew is one of the most important diseases of ... have discovered the composition of special growths on the cell ... fungus into the leaf. , The research, by the ARC ...
(Date:7/25/2014)... age girls reach puberty is influenced by ,imprinted genes,a subset ... the gene. This is the first evidence that imprinted ... details of this study were published today in the journal ... as menarche, is a marker for the timing of puberty ... menses varies between girls, is an inherited trait, and is ...
(Date:7/25/2014)... , July 25, 2014 ... consumers are turning to digital technology for online & ... NXTD), Google Inc. (NASDAQ: GOOG ), LifeLock ... V ), Apple Inc. (NASDAQ: ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ...
Breaking Biology News(10 mins):New hope for powdery mildew resistant barley 2Could age of first period influence development of diseases in older women? 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6
... Plasmodium falciparum uses different pathways to invade ... complicating efforts to create effective vaccines against the disease. ... an international research scholar with the Howard Hughes Medical ... to switch back and forth between invasion pathways. ...
... process that has stumped scientists for many years: exactly ... cell's nucleus, where it has strong anti-carcinogenic effects. , ... door for future research on related compounds. The finding ... other diseases. , The research, which appears in a ...
... porphyria , Dana-Farber Cancer Institute researchers say they have ... irrational and demented behavior in porphyria, the disease believed ... ruler blamed for the loss of the American colonies ... symptoms of porphyria, a rare genetic blood disease which ...
Cached Biology News:Gene expands malaria's invasion options 2Gene expands malaria's invasion options 3Study shows how retinoic acid enters a cell's nucleus 2Study shows how retinoic acid enters a cell's nucleus 3Attacks of King George III's madness linked to key metabolism molecule 2Attacks of King George III's madness linked to key metabolism molecule 3
(Date:7/24/2014)... 2014  Neogen Corporation (Nasdaq: NEOG ) ... potential revenue from new rodenticide research are premature. In ... on July 22, 2014, Neogen,s CEO commented about several ... "It was my intent Tuesday at our ... a new type of rodenticide, but certainly not to ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 1000 balances ... takes input on customers’ weighing needs and expertly narrows ... shortlist of balances, scales or even terminals. , ... and smallest weight (or select readability instead) and define ... few additional selection criteria narrows down the list to ...
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 ... http://www.draperuniversity.com , is proud to announce that for ... 17 different countries will converge on the Draper ... for an intensive, experiential program focused on entrepreneurship, ... highly selective school, currently running its sixth cohort, ...
(Date:7/24/2014)...   Cypher Genomics, Inc., the genome ... Adam Simpson as president and chief operating ... annotation and interpretation of individual human genomes for ... technology has the potential to play a transformative ... optimizing therapeutic approaches and reducing adverse drug reactions," ...
Breaking Biology Technology:Neogen comments on SenesTech 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3
... Calif., Sept. 27 Poniard,Pharmaceuticals, Inc. (Nasdaq: ... announced that the Company,s common shares are now,eligible ... and will begin trading,there under the same symbol ... for listing on the NASDAQ Global Market represents ...
... 454 Life Sciences, a Roche,company, in collaboration with ... a method, using the company,s Genome Sequencer(TM),FLX system, ... level of detail. The new method enables researchers ... to the,genetic code in a very fast and ...
... strategic plan, WATERTOWN, Mass., Sept. 27 ... Biomedical Research Institute, an independent,not-for- profit biomedical research ... scientists, a 23% increase in its scientific staff. ... fruits of a three-year,strategic planning process designed to ...
Cached Biology Technology:Poniard Pharmaceuticals Announces Upgrade of Stock Listing to NASDAQ Global Market 2454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation 2454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation 3New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 3
... the original Gene Pulser apparatus and accessory modules ... applied in the Gene Pulser II system, which ... the Gene Pulser II system has the dual ... widest range of settings to target specific cell ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... the submicron range are part of your ... control of particle size is important to ... reliably detect the component populations in your ... Size Analyzer uses Photon Correlation Spectroscopy (PCS) ...
...
Biology Products: