Navigation Links
Study finds genes that keep watch on blood clotting time
Date:3/22/2010

Scientists have discovered three genes that could shed light on the genetic causes of blood-clotting disorders such as thrombosis and some types of stroke.

Researchers at the University of Edinburgh have discovered that the three genes make a substantial contribution to how long it takes blood to clot.

The team thinks that identifying these genes that control the way blood clots could help further our understanding of conditions such as deep vein thrombosis, heart attacks, some types of stroke, and bleeding disorders.

The study was carried out at the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), part of the cross council Lifelong Health and Wellbeing Initiative.

The study looked for associations between half a million genetic markers and time taken for blood to clot, measured by a test called activated partial thromboplastin time (aPTT).

The findings show three genes - called F12, HRG and KNG1 - are responsible for a substantial amount of the variation in speed of blood clotting in different healthy people.

The team will now try to encourage research teams working on relevant medical disorders to study these genes.

The participants in the study were members of the Lothian Birth Cohorts of 1921 and 1936 who live in the Edinburgh area and took part in the Scottish Mental Surveys of 1932 and 1947.

The Lothian Birth Cohorts, now aged over 70, are being tested by Professor Ian Deary and his team at the University of Edinburgh to find clues to healthy ageing.

Dr Lorna Houlihan, from the University of Edinburgh performed the analysis with help from experts in Edinburgh, Glasgow, and Brisbane She said: "This is an exciting genetic discovery, especially as so few genes account for such a large effect. We have explored the genetics of the medical information that has been given by our cohorts of older people. When I saw this huge finding on the genetics of blood clotting I first checked that it occurred in both our groups - it did. Then I checked that no-one else had discovered this - they hadn't. Then the team set about establishing the possible medical implications for some blood disorders."

Professor Ian Deary, Director of the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), who led the research, said: "The team is excited to have contributed this 'first' in the genetics of blood clotting. Within the team we are lucky to have experts in medicine, genetics and blood coagulation, who helped enormously in appreciating just how big a discovery this was. We are now following up these findings to establish their clinical significance."

The results are published in the American Journal of Human Genetics.


'/>"/>

Contact: Joanne Morrison
joanne.morrison@ed.ac.uk
44-131-651-4266
University of Edinburgh
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... Yorba Linda, Ca (PRWEB) , ... May 25, ... ... essential to truly understanding the full process behind each occurrence. Live cell imaging ... , In this webinar, the use of automated fluorescence microscopy methods will be ...
(Date:5/24/2017)... ... May 24, 2017 , ... Today, the South Davis Sewer ... Biological Nutrient Recovery (ABNRâ„¢) technology at its 4,000,000 gallon per day South Plant. ... sustainably meet current and future nutrient discharge regulations. The ABNR platform, which is ...
(Date:5/24/2017)... 2017 (PRWEB) , ... May 24, 2017 , ... ... Medical systems are increasingly being developed with Wi-Fi connectivity to reduce the amount ... from room to room. In addition, compact mobile devices including infusion pumps, heart ...
(Date:5/23/2017)... ... May 23, 2017 , ... A recent survey conducted by the Weed Science ... control weed in 12 categories of broadleaf crops, fruits and vegetables, while common lambsquarters ... U.S. and Canada participated in the 2016 survey, the second conducted by WSSA. ...
Breaking Biology Technology: