Navigation Links
Study finds genes that keep watch on blood clotting time

Scientists have discovered three genes that could shed light on the genetic causes of blood-clotting disorders such as thrombosis and some types of stroke.

Researchers at the University of Edinburgh have discovered that the three genes make a substantial contribution to how long it takes blood to clot.

The team thinks that identifying these genes that control the way blood clots could help further our understanding of conditions such as deep vein thrombosis, heart attacks, some types of stroke, and bleeding disorders.

The study was carried out at the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), part of the cross council Lifelong Health and Wellbeing Initiative.

The study looked for associations between half a million genetic markers and time taken for blood to clot, measured by a test called activated partial thromboplastin time (aPTT).

The findings show three genes - called F12, HRG and KNG1 - are responsible for a substantial amount of the variation in speed of blood clotting in different healthy people.

The team will now try to encourage research teams working on relevant medical disorders to study these genes.

The participants in the study were members of the Lothian Birth Cohorts of 1921 and 1936 who live in the Edinburgh area and took part in the Scottish Mental Surveys of 1932 and 1947.

The Lothian Birth Cohorts, now aged over 70, are being tested by Professor Ian Deary and his team at the University of Edinburgh to find clues to healthy ageing.

Dr Lorna Houlihan, from the University of Edinburgh performed the analysis with help from experts in Edinburgh, Glasgow, and Brisbane She said: "This is an exciting genetic discovery, especially as so few genes account for such a large effect. We have explored the genetics of the medical information that has been given by our cohorts of older people. When I saw this huge finding on the genetics of blood clotting I first checked that it occurred in both our groups - it did. Then I checked that no-one else had discovered this - they hadn't. Then the team set about establishing the possible medical implications for some blood disorders."

Professor Ian Deary, Director of the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), who led the research, said: "The team is excited to have contributed this 'first' in the genetics of blood clotting. Within the team we are lucky to have experts in medicine, genetics and blood coagulation, who helped enormously in appreciating just how big a discovery this was. We are now following up these findings to establish their clinical significance."

The results are published in the American Journal of Human Genetics.


Contact: Joanne Morrison
University of Edinburgh

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
(Date:10/4/2017)... a global clinical research organization (CRO), announces the launch of Shadow, ... 2017. Shadow is designed to assist medical writers and biometrics teams ... European Medicines Agency (EMA) in meeting the requirements for de-identifying clinical ... ... Tom ...
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
Breaking Biology Technology: