Navigation Links
Study finds diet and alcohol alter epigenetics of breast cancer
Date:7/30/2010

PROVIDENCE, R.I. [Brown University] Researchers from Brown University and the University of California San Francisco have found that epigenetic changes to DNA in breast cancers are related to environmental risk factors and tumor size, providing a window into the severity of the disease. The study is published in today's edition of PLoS Genetics. The researchers found that epigenetic profiles of tumors had a direct association with diet, alcohol, and tumor size.

The findings point to the emergence of new biomarkers that researchers hope will give a more detailed view of the environmental factors that contribute to tumor development and could, in the future, provide improvements in diagnostics and treatment decisions, as well as potentially more personalized recommendations to help prevent recurrence. The use of epigenetic profiles as biomarkers of disease subtype and severity is a rapidly emerging field with other notable contributions from this group; a field that is being advanced with the support of the NIH, and shows promise for developing novel clinical tools.

"We undertook this study to help illuminate how diet and environmental factors might contribute to differences observed among breast cancers," said Brock Christensen of the Center for Environmental Health and Technology (CEHT) at Brown University and lead author of the report.

The study measured epigenetic profiles in stage I to IV breast tumors from 162 women enrolled in the Pathways Study, a study of breast cancer survivorship based at Kaiser Permanente of Northern California. The researchers took a detailed assessment of an individual's demographic and dietary information, as well as breast cancer tumor characteristics. The study's data show the promise of tumor epigenetic signatures to provide more detailed tumor staging, and eventually prediction of prognosis. In particular, the study found that alcohol consumption, folate intake (vitamin B9), and tumor size are each independently associated with epigenetic profiles of tumors.

"By investigating epigenetic patterns in tumors from patients we have extensive lifestyle data on, we are helping to bridge the gap between environmental research and translational research." said Karl Kelsey, professor of community health at Brown, director of CEHT, and a contributing author on the paper.

Epigenetics refers to the control of patterns of gene expression in cells, which give rise to the necessary differences responsible for creating the complex and interacting tissues in the body.

"This study provides a new window for finding environmental links to breast disease," said John Wiencke, professor of neurosurgery at the University of California, San Francisco and senior author of the paper. "Our work indicates that we will soon have new ways to monitor and assess lifestyle and environmental factors for breast cancer."


'/>"/>

Contact: Sarah Kidwell
Sarah_Kidwell@brown.edu
401-863-2752
Brown University
Source:Eurekalert

Related biology news :

1. Study finds black carbon implicated in global warming
2. Scripps research study opens the door to new class of drugs for epileptic seizures
3. New study reveals decline of marine phytoplankton over the past century
4. NJIT professor receives Fulbright to study at University of Salerno
5. Study suggests swimmers at sub-tropical beaches show increased risk of illness
6. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
7. Neiker-Tecnalia study use of oilseedrape and sunflower oils to produce fuel and feed for herds
8. Study recommends that parents, physicians share decisions in sex development disorder surgery
9. UT MD Anderson study ties abnormal cells in blood to lung cancer
10. Kids could get more whole grains from after-school snacks, University of Minnesota study finds
11. NIH awards National Jewish Health $31 million to lead study of infections associated with eczema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their ... (DCA). ... launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at ... process to allow eligible Delta SkyMiles Members who are enrolled in CLEAR ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
Breaking Biology Technology: