Navigation Links
Study finds diet and alcohol alter epigenetics of breast cancer
Date:7/30/2010

PROVIDENCE, R.I. [Brown University] Researchers from Brown University and the University of California San Francisco have found that epigenetic changes to DNA in breast cancers are related to environmental risk factors and tumor size, providing a window into the severity of the disease. The study is published in today's edition of PLoS Genetics. The researchers found that epigenetic profiles of tumors had a direct association with diet, alcohol, and tumor size.

The findings point to the emergence of new biomarkers that researchers hope will give a more detailed view of the environmental factors that contribute to tumor development and could, in the future, provide improvements in diagnostics and treatment decisions, as well as potentially more personalized recommendations to help prevent recurrence. The use of epigenetic profiles as biomarkers of disease subtype and severity is a rapidly emerging field with other notable contributions from this group; a field that is being advanced with the support of the NIH, and shows promise for developing novel clinical tools.

"We undertook this study to help illuminate how diet and environmental factors might contribute to differences observed among breast cancers," said Brock Christensen of the Center for Environmental Health and Technology (CEHT) at Brown University and lead author of the report.

The study measured epigenetic profiles in stage I to IV breast tumors from 162 women enrolled in the Pathways Study, a study of breast cancer survivorship based at Kaiser Permanente of Northern California. The researchers took a detailed assessment of an individual's demographic and dietary information, as well as breast cancer tumor characteristics. The study's data show the promise of tumor epigenetic signatures to provide more detailed tumor staging, and eventually prediction of prognosis. In particular, the study found that alcohol consumption, folate intake (vitamin B9), and tumor size are each independently associated with epigenetic profiles of tumors.

"By investigating epigenetic patterns in tumors from patients we have extensive lifestyle data on, we are helping to bridge the gap between environmental research and translational research." said Karl Kelsey, professor of community health at Brown, director of CEHT, and a contributing author on the paper.

Epigenetics refers to the control of patterns of gene expression in cells, which give rise to the necessary differences responsible for creating the complex and interacting tissues in the body.

"This study provides a new window for finding environmental links to breast disease," said John Wiencke, professor of neurosurgery at the University of California, San Francisco and senior author of the paper. "Our work indicates that we will soon have new ways to monitor and assess lifestyle and environmental factors for breast cancer."


'/>"/>

Contact: Sarah Kidwell
Sarah_Kidwell@brown.edu
401-863-2752
Brown University
Source:Eurekalert

Related biology news :

1. Study finds black carbon implicated in global warming
2. Scripps research study opens the door to new class of drugs for epileptic seizures
3. New study reveals decline of marine phytoplankton over the past century
4. NJIT professor receives Fulbright to study at University of Salerno
5. Study suggests swimmers at sub-tropical beaches show increased risk of illness
6. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
7. Neiker-Tecnalia study use of oilseedrape and sunflower oils to produce fuel and feed for herds
8. Study recommends that parents, physicians share decisions in sex development disorder surgery
9. UT MD Anderson study ties abnormal cells in blood to lung cancer
10. Kids could get more whole grains from after-school snacks, University of Minnesota study finds
11. NIH awards National Jewish Health $31 million to lead study of infections associated with eczema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... MOINES, Iowa , Jan. 11, 2017 ... industry first with the release of its patent-pending calibration ... quickly and reliably perform calibrations, securely upload data logs ... flexibility for the customer. "Fighting drunk driving ... only for the public at large, but also for ...
(Date:1/6/2017)...  Delta ID Inc., a leader in consumer-grade iris ... at CESĀ® 2017. Delta ID has collaborated with Gentex ... use of iris scanning as a secure, reliable and ... a car, and as a way to elevate the ... Delta ID and Gentex will demonstrate (booth #7326 LVCC) ...
(Date:12/22/2016)... Calif. , Dec. 20, 2016  As part of ... 23andMe, the leading personal genetics company, recently released its latest ... . The book focuses on the topics of inheritance ... Generation Science Standards (NGSS) taught in elementary school classrooms in ... in a series by illustrator Ariana Killoran , whose ...
Breaking Biology News(10 mins):
(Date:1/13/2017)... Jan 13, 2017 Research and Markets has announced ... their offering. ... biopolymers market to grow at a CAGR of 16.83% during the period ... growth prospects of the global biopolymers market for 2017-2021. To calculate the ... sales of biopolymer products. The report also includes a a discussion of ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci, in ... its customers three new solutions for measurements where traditional cuvette applications are not ... customer has an oddly-shaped sample that would not fit into a typical cuvette ...
(Date:1/12/2017)... , ... January 12, 2017 ... ... devices with short response times capable of performing routine electrochemical biosensing has ... screen-printed electrodes provide fast, sensitive detection and quantification of various analytes in ...
(Date:1/12/2017)... , January 12, 2017 ... the world,s biggest facility for producing mycorrhizae. The Centre ... nutrient tapping potential of mycorrhizae and developed a technology ... ... http://mma.prnewswire.com/media/456932/PRNE_TERI_Logo.jpg) The TERI facility has ...
Breaking Biology Technology: