Navigation Links
Study finds depletion of alveolar macrophages linked to bacterial super-infections
Date:7/22/2013

A recent study published in the July issue of the Journal of Immunology helps explain why some humans contract bacterial super-infections like pneumonia with influenza. The research was led by Le Bonheur Pediatrician-in-Chief Jon McCullers, MD an infectious disease specialist who is also chair of the Department of Pediatrics for the University of Tennessee Health Science Center and adjunct faculty at St. Jude Children's Research Hospital.

"It's been known that the influenza virus does something to suppress host immune function, which can facilitate development of deadly secondary bacterial pneumonias," said McCullers. "But we haven't known what that was or why it happens."

McCullers' research conducted at his National Institutes of Health-funded laboratory at St. Jude Children's Research Hospital by UTHSC graduate student Hazem Ghoneim, a PhD candidate -- used advanced techniques to differentiate types of alveolar macrophages found in the lungs and airways. Researchers found that of the three types identified, only one is truly capable of fending off secondary bacterial infection. This population of macrophages, labeled the resident alveolar macrophages, is depleted during a flu infection.

"We found that influenza is specifically killing these true alveolar macrophages," said McCullers. "The window of time someone is susceptible to secondary infections corresponds with the time it takes for the other two types of alveolar macrophages to differentiate so they are then able to fight off the infection."

McCullers says his study is a step toward developing strategies for treatment.

"This discovery provides a roadmap for developing immunotherapies that can supplement the natural defenses of our body when they are at their weakest. Influenza and pneumonia are the seventh leading cause of death in the U.S., and we desperately need research such as this to improve our armamentarium," said McCullers.


'/>"/>

Contact: Sara Burnett
sara.burnett@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. New study finds nighttime heat waves increasing in Pacific Northwest
2. Study finds missing piece of pediatric cancer puzzle
3. Its not just the heat -- its the ozone: Study highlights hidden dangers
4. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
5. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
6. Study identifies Deepwater Horizon debris as likely source of Gulf of Mexico oil sheens
7. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
8. U of T-led study cracks universal RNA code, suggests a new cause for autism
9. Study finds surprising benefits about diary cow inflammation
10. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
11. Journal highlights Arctic sea ice study by UM professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... 21, 2017 Vigilant Solutions , a ... enforcement agencies, announced today the appointment of retired FBI ... public safety business development. Mr. Sheridan brings ... including a focus on the aviation transportation sector, to ... position, Mr. Sheridan served as the Aviation Liaison Agent ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge Semantics , the leading provider of ... Bio-IT World Conference and Expo in Boston May 23-25 with a featured speaker ... Anzo Smart Data Lake is also a finalist for the Best of Show award. ...
(Date:5/22/2017)... Boston, MA (PRWEB) , ... May 22, 2017 , ... ... evidence, has expanded to the East Coast. It has opened an office in downtown ... innovative therapies are finding it increasingly more important to generate evidence on the value ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... today that it is exhibiting in booth B2 at the Association for ... May 22-25. , In addition to demonstrating its Cancer Diagnostic Cockpit and ...
(Date:5/21/2017)... ... May 20, 2017 , ... CNSDose is a genetically driven, ... process by finding the right antidepressant faster. CNSDose speeds recovery and reduces ... a personalized approach to treatment. , A peer-reviewed and published, 12-week ...
Breaking Biology Technology: