Navigation Links
Study finds depletion of alveolar macrophages linked to bacterial super-infections
Date:7/22/2013

A recent study published in the July issue of the Journal of Immunology helps explain why some humans contract bacterial super-infections like pneumonia with influenza. The research was led by Le Bonheur Pediatrician-in-Chief Jon McCullers, MD an infectious disease specialist who is also chair of the Department of Pediatrics for the University of Tennessee Health Science Center and adjunct faculty at St. Jude Children's Research Hospital.

"It's been known that the influenza virus does something to suppress host immune function, which can facilitate development of deadly secondary bacterial pneumonias," said McCullers. "But we haven't known what that was or why it happens."

McCullers' research conducted at his National Institutes of Health-funded laboratory at St. Jude Children's Research Hospital by UTHSC graduate student Hazem Ghoneim, a PhD candidate -- used advanced techniques to differentiate types of alveolar macrophages found in the lungs and airways. Researchers found that of the three types identified, only one is truly capable of fending off secondary bacterial infection. This population of macrophages, labeled the resident alveolar macrophages, is depleted during a flu infection.

"We found that influenza is specifically killing these true alveolar macrophages," said McCullers. "The window of time someone is susceptible to secondary infections corresponds with the time it takes for the other two types of alveolar macrophages to differentiate so they are then able to fight off the infection."

McCullers says his study is a step toward developing strategies for treatment.

"This discovery provides a roadmap for developing immunotherapies that can supplement the natural defenses of our body when they are at their weakest. Influenza and pneumonia are the seventh leading cause of death in the U.S., and we desperately need research such as this to improve our armamentarium," said McCullers.


'/>"/>

Contact: Sara Burnett
sara.burnett@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. New study finds nighttime heat waves increasing in Pacific Northwest
2. Study finds missing piece of pediatric cancer puzzle
3. Its not just the heat -- its the ozone: Study highlights hidden dangers
4. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
5. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
6. Study identifies Deepwater Horizon debris as likely source of Gulf of Mexico oil sheens
7. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
8. U of T-led study cracks universal RNA code, suggests a new cause for autism
9. Study finds surprising benefits about diary cow inflammation
10. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
11. Journal highlights Arctic sea ice study by UM professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
(Date:7/10/2014)... New York , July 7, 2014 ... by Transparency Market Research "Electronic Access Control Systems Market ... 2014 - 2019," the global Electronic Access Control systems ... and is expected to grow at a CAGR of ... value of USD 31,187.8 million in 2019. ...
(Date:7/10/2014)... -- Acuity Market Intelligence today released forecasts from "The Global ... global market for National Electronic ID (eID) programs will generate ... time, the number of National eID cards in circulation will ... , with its vast population, will dominate the market ... Europe trails a distant second at ...
Breaking Biology News(10 mins):Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... Through an innovative feat of plant biotechnology and vaccine ... University have successfully turned tobacco plants into vaccine production ... vaccine elicits a protective immune response in guinea pigs. ... the future development of a new vaccine for human ...
... of molecule which they believe could ultimately lead to ... modified tobacco. Writing in Plant Biotechnology Journal, Dr Patricia ... along with researchers at the University of Warwick say ... far frustrated attempts to turn plants into economically viable ...
... Just as baby mammals depend on their mothers' milk, ... themselves by stripping off and eating the fat-rich outer ... team of researchers that includes University of Michigan biologist ... issue (April 13) of the journal Nature. , Hatchlings ...
Cached Biology News:Plant-derived vaccines safeguard against deadly plague 2Plant-derived vaccines safeguard against deadly plague 3Do plants have the potential to vaccinate against HIV? 2African amphibians make extreme parental sacrifice: The skin off their backs 2African amphibians make extreme parental sacrifice: The skin off their backs 3
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... may help in the fight against terrorism with the ... of explosives with the use of light and special ... and Actuators B: Chemical , the researchers describe a ... concentrations as low as 6.3 ppm (parts per million). ... minutes. , "Traditionally explosives detection has involved looking for ...
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... Correct the Record and Provide Accurate Information to ... ... 20 VaxGen,Inc. (Pink Sheets: VXGN), (Logo: http://www.newscom.com/cgi-bin/prnh/19991112/VAXGENLOGO ), ... biotechnologies announced on,November 12, 2007 that their respective Boards of Directors ...
... ExL Pharma is pleased to announce the,fall ... leading issues that are,impacting the pharmaceutical industry today. ... networking opportunities for Clinical,Marketing, R&D, and Medical Affairs ... technology companies. Listed below are details on ...
... Tools Experience to the Leader in ... Cellular Bioenergetic Profiling, N. ... tools for real-time measurement of cellular,bioenergetics in microplates, announced today ... the company,s Board of,Directors. In this position, Keegan will apply ...
Cached Biology Technology:VaxGen Addresses MPM Claims in Letter to Stockholders 2VaxGen Addresses MPM Claims in Letter to Stockholders 3VaxGen Addresses MPM Claims in Letter to Stockholders 4VaxGen Addresses MPM Claims in Letter to Stockholders 5VaxGen Addresses MPM Claims in Letter to Stockholders 6VaxGen Addresses MPM Claims in Letter to Stockholders 7VaxGen Addresses MPM Claims in Letter to Stockholders 8VaxGen Addresses MPM Claims in Letter to Stockholders 9Pfizer, Genentech, Amgen, Bayer, Wyeth, Abbott, Merck and Additional Leading Pharmaceutical Companies Participating During ExL Pharma's Fall Line Up! 2Seahorse Bioscience Appoints Former Molecular Devices Executive Dr. Joseph D. Keegan to Board of Directors 2
MpV17 transgene, murine homolog, glomerulosclerosis...
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Human LT beta R/TNFRSF3 Phycoerythrin MAb (Clone 71319)...
Biology Products: