Study finds cancer-fighting goodness in c... ( A Simon Fraser University researcher ...)

Study finds cancer-fighting goodness in cholesterol

Date:4/19/2012

A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry.

The scientists came to their conclusion while trying to understand how cholesterol moves around inside cells in the fat's journey to cell surfaces where it reinforces their outer membrane.

"The assumption was that ORPs bind and transport cholesterol inside cells in a similar fashion to how lipoproteins bind and move around the fat outside cells through the blood stream," explains Chris Beh. The SFU associate professor of molecular biology and biochemistry co-authored this paper.

Beh and his colleagues noted that genetic changes engineered by them block the ability of ORPs to bind cholesterol but don't stop ORPs from functioning. In fact, these altered ORPs work better and activate other regulator proteins, which in turn trigger a variety of cellular processes that stimulate cell growth.

The scientists believe this happened because cholesterol-binding normally interferes with ORPs' ability to bind to another lipid or fat called PI4P, which is important for cell growth.

"That told us that ORPs probably have nothing to do with moving around cholesterol within cells," says Beh. "Rather cholesterol-binding puts the brakes on ORP's ability to bind to PI4P which, if left unchecked, could accelerate cell growth like crazy," says Beh. "Given that uncontrolled cell growth is a key feature of cancer, this means gaining a better understanding of the true purpose of cholesterol-binding within cells could be important in cancer treatment."

Beh and his colleagues draw on two important facts to support their conclusion.

"First, cancer cells require ORPs to survive," explains
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3210
Simon Fraser University
Source:Eurekalert

1

GOOD

Page: 1 2
Related biology news :

1. New study links air pollution and early death in the UK
2. Effect of chronic exposure to chemicals used as weapons, pesticides under study
3. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
4. Jellyfish on the rise: UBC study
5. Improved loblolly pines better for the environment, study finds
6. Study amplifies understanding of hearing in baleen whales
7. Large international study finds memory in adults impacted by versions of 4 genes
8. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
9. Whats in a surname? New study explores what the evolution of names reveals about China
10. U of I study: Lose body weight before gaining baby weight
11. Study resolves debate on human cell shut-down process

Post Your Comments:

(Date:6/17/2013)... research published in Biochemical and Biophysical Research Communications ... can detect new, previously unknown viruses. The technique offers ... doctors have not identified a particular virus as the ... the new approach, scientists use blood serum as a ... advantage of the complete deciphering of the human genome, ...

(Date:6/17/2013)... MANHATTAN, KAN. -- A Kansas State University research associate ... on mosquitoes and ways to prevent the spread of ... received the National Institutes of Health,s National Research Service ... years. He is the seventh Kansas State University researcher ... on campus to currently hold such an award. , ...

(Date:6/17/2013)... . A new ... disease can be reversed with treatment. The study by researchers ... at McGill University and at Universit de Montral found that ... of mice with advanced Alzheimer,s disease (AD) recovers memory and ... Neuroinflammation in May, also suggest an underlying mechanism of ...

Breaking Biology News(10 mins):Saint Louis University researchers discover a way to detect new viruses 2 Saint Louis University researchers discover a way to detect new viruses 3 NIH fellowship helps researcher fight malaria, understand mosquito immunity 2 Blocking overactive receptor in Alzheimer's recovers memory loss and more 2

[0] Saint Louis University researchers discover a way to detect new viruses [0] NIH fellowship helps researcher fight malaria, understand mosquito immunity [0] Blocking overactive receptor in Alzheimer's recovers memory loss and more

... plants--is the most abundant biological material on Earth. ... plant-based biofuels research. Despite overwhelming interest, scientists know ... cellulose fibers. , However, recent work from the ... University describes the first real-time observations of cellulose ...

... of biomedical engineering at New Jersey Institute of Technology (NJIT) ... has received two grants that will help her bring the ... , Arinzeh received a $700,000 grant from ... agency that funds spinal cord research. She will use the ...

... When medics are treating trauma patients, every second counts. ... it difficult to locate veins and administer lifesaving drugs ... Institute of Technology researchers is developing an inexpensive, handheld ... quickly. , "Depth and angle are the critical ...

Cached Biology News:Formation of cellulose fibers tracked for the first time 2 NJIT engineer poised to take stem cell research a step forward 2 NJIT engineer poised to take stem cell research a step forward 3 Researchers develop portable 'vein finder' for faster, more accurate injections 2 Researchers develop portable 'vein finder' for faster, more accurate injections 3

Formation of cellulose fibers tracked for the first time NJIT engineer poised to take stem cell research a step forward Researchers develop portable 'vein finder' for faster, more accurate injections

(Date:6/18/2013)... Clara, CA (PRWEB) June 18, 2013 ... to standard size SEMs but have limited performance and ... lower resolution. Full size SEMs would normally provide better ... more knowledge to operate and have a higher cost ... address the gap between these two types of ...

(Date:6/18/2013)... 2013) A million electric cars could be on roads ... the help of research by the United States Department of ... , Professor Zhongwei Chen is part of a team led ... materials to replace the expensive platinum catalysts in fuel cells. ... fuel cells in vehicles is the cost of the units. ...

(Date:6/18/2013)... Cord Blood Corporation (NYSE: CO ) ("CCBC" ... collection, laboratory testing, hematopoietic stem cell processing, and stem ... results for the fourth quarter and full year of ... Fourth Quarter of Fiscal 2013 Highlights , ... by 33.3% to RMB133.0 million ($21.4 million) from RMB99.8 ...

(Date:6/18/2013)... June 18, 2013 In support of ... the Consulate General of Switzerland in New York is ... Switzerland’s MS Tûranor PlanetSolar , to Manhattan. PlanetSolar ... DeepWater Expedition 2013 tour with scientists on board from ... Gérard d’Aboville, runs exclusively on energy from the sun ...

[0] Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes [0] US and Canadian researchers drive towards cheaper fuel cells for electric cars [0] China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 [0] Switzerland’s MS Tûranor PlanetSolar, the World’s Largest Solar Boat, Arrives in New York City

... a novel class of intracellular protein biologics, today ... of naturally occurring human supercharged proteins called Intraphilins. ... human proteins enable biologic drugs to penetrate and ... of proteins is the foundation of Permeon Biologics, ...

... form protein clumps in the body, then alarm bells ... associated with Alzheimer,s disease and type 2 diabetes, formerly ... proteins form clumps, then they might be able to ... Keller and his colleagues at the Helmholtz-Zentrum Dresden-Rossendorf and ...

... 2011 Gen-Probe Incorporated (NASDAQ: GPRO ) today ... total revenues of $135.9 million and non-GAAP earnings per share ... of APTIMA women,s health products in the second quarter of ... decline compared to strong sales a year ago," said Carl ...

Permeon reveals discovery of Intraphilins as new approach to intracellular biologic drugs In the pursuit of dangerous clumps Gen-Probe Reports Financial Results for the Second Quarter of 2011

... Maximize the value of your microarray ... offer the support you need from ... the most up to date methods. ... the Gene Expression Profiling Service or ...

... number is a new product number, ... number. If showing no availability yet, ... number (Z71,517-4) or contact customer service ... (expanded surface, easy grip) ...

... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...

... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ...

Biology Products:

Illumina Standard Data Analysis Report from Asuragen, Inc.CORNING 1700CM2 ROLLER BOTTLE, EASY GRIP CAP, GRADUATED, STERILE from Sigma-Aldrich CORNING ROLLER BOTTLES, 490 CM2, PS CAP, PLUG SEAL, STERILE from Sigma-Aldrich CORNING ROLLER BOTTLE WITH CELLBIND, 1700CM2, STERILE from Sigma-Aldrich