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Study finds axon regeneration after Schwann cell graft to injured spinal cord
Date:12/23/2013

es across transplant interfaces likely establishes three-dimensional structures that determine how regenerating axons become exposed to myriad growth-promoting and inhibitory cues," wrote the researchers. The researchers also noted that it was important to understand conditions that favor astrocytes to be permissive for axonal growth into lesion transplants.

"We demonstrated that the elongation of astrocyte processes into SC transplants, and the formation of NG2+ tunnels, enables brainstem axon regeneration and improvement in function," they concluded. "This study supports the clinical use of SCs for SCI repair and defines important characteristics of permissive spinal cord/graft interfaces."

"Developing the means to bridge the glial scar following chronic spinal cord injury is one of the major stumbling blocks of therapy" said Dr. John Sladek, Cell Transplantation section editor and professor of neurology and pediatrics at the University of Colorado School of Medicine. "This study provides important new insight into how this may be achieved".


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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