Navigation Links
Study finds axon regeneration after Schwann cell graft to injured spinal cord
Date:12/23/2013

Putnam Valley, NY. (Dec. 23 2013) A study carried out at the University of Miami Miller School of Medicine for "The Miami Project to Cure Paralysis" has found that transplanting self-donated Schwann cells (SCs, the principal ensheathing cells of the nervous system) that are elongated so as to bridge scar tissue in the injured spinal cord, aids hind limb functional recovery in rats modeled with spinal cord injury.

The study will be published in a future issue of Cell Transplantation but is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1074Williams.

"Injury to the spinal cord results in scar and cavity formation at the lesion site," explains study corresponding author Dr. Mary Bartlett Bunge of the University of Miami Miller School of Medicine. "Although numerous cell transplantation strategies have been developed to nullify the lesion environment, scar tissue - in basil lamina sheets - wall off the lesion to prevent further injury and, also, at the interface, scar tissue impedes axon regeneration into and out of the grafts, limiting functional recovery."

The researchers determined that the properties of a spinal cord/Schwann cell bridge interface enable regenerated and elongated brainstem axons to cross the bridge and potentially lead to an improvement in hind limb movement of rats with spinal cord injury.

Electron microscopy revealed that axons, SCs, and astrocytes were enclosed together within tunnels bounded by continuous basal lamina. The expression of neuroglycan (NG2; a proteoglycan found on the membrane of cells) was associated with these tunnels. They subsequently determined that a "trio" of astrocyte processes, SCs and regenerating axons were "bundled" together within the tunnels of basal lamina.

"Elongation of astrocyte processes across transplant interfaces likely establishes three-dimensional structures that determine how regenerating axons become exposed to myriad growth-promoting and inhibitory cues," wrote the researchers. The researchers also noted that it was important to understand conditions that favor astrocytes to be permissive for axonal growth into lesion transplants.

"We demonstrated that the elongation of astrocyte processes into SC transplants, and the formation of NG2+ tunnels, enables brainstem axon regeneration and improvement in function," they concluded. "This study supports the clinical use of SCs for SCI repair and defines important characteristics of permissive spinal cord/graft interfaces."

"Developing the means to bridge the glial scar following chronic spinal cord injury is one of the major stumbling blocks of therapy" said Dr. John Sladek, Cell Transplantation section editor and professor of neurology and pediatrics at the University of Colorado School of Medicine. "This study provides important new insight into how this may be achieved".


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
2. Study offers clues to how plants evolved to cope with cold
3. Study shows Where Alzheimers starts and how it spreads
4. Study: Some plants may not adapt quickly to future climate change
5. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
6. Nutrition influences metabolism through circadian rhythms, UCI study finds
7. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
8. Deepwater Horizon NRDA study shows possible oil impact on dolphins
9. New study reveals the biomechanics of how marine snail larvae swim
10. Study finds Catalina Island Conservancy contraception program effectively manages bison population
11. Study led by NUS scientists provides new insights into cause of human neurodegenerative disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled a ... new look is part of a transformation to increase awareness, appeal to new markets ... It will also expand its service offering from its signature gourmet cooking classes and ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... At its ... Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has ... was a member of the winning team for the 2015 Breakthrough Prize in Fundamental ...
(Date:10/7/2017)... , Oct. 6, 2017  The 2017 Nobel ... three scientists, Jacques Dubochet, Joachim Frank ... in cryo-electron microscopy (cryo-EM) have helped ... the structural biology community. The winners worked with ... now routinely produce highly resolved, three-dimensional images of ...
Breaking Biology Technology: