Navigation Links
Study finds axon regeneration after Schwann cell graft to injured spinal cord
Date:12/23/2013

Putnam Valley, NY. (Dec. 23 2013) A study carried out at the University of Miami Miller School of Medicine for "The Miami Project to Cure Paralysis" has found that transplanting self-donated Schwann cells (SCs, the principal ensheathing cells of the nervous system) that are elongated so as to bridge scar tissue in the injured spinal cord, aids hind limb functional recovery in rats modeled with spinal cord injury.

The study will be published in a future issue of Cell Transplantation but is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1074Williams.

"Injury to the spinal cord results in scar and cavity formation at the lesion site," explains study corresponding author Dr. Mary Bartlett Bunge of the University of Miami Miller School of Medicine. "Although numerous cell transplantation strategies have been developed to nullify the lesion environment, scar tissue - in basil lamina sheets - wall off the lesion to prevent further injury and, also, at the interface, scar tissue impedes axon regeneration into and out of the grafts, limiting functional recovery."

The researchers determined that the properties of a spinal cord/Schwann cell bridge interface enable regenerated and elongated brainstem axons to cross the bridge and potentially lead to an improvement in hind limb movement of rats with spinal cord injury.

Electron microscopy revealed that axons, SCs, and astrocytes were enclosed together within tunnels bounded by continuous basal lamina. The expression of neuroglycan (NG2; a proteoglycan found on the membrane of cells) was associated with these tunnels. They subsequently determined that a "trio" of astrocyte processes, SCs and regenerating axons were "bundled" together within the tunnels of basal lamina.

"Elongation of astrocyte process
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
2. Study offers clues to how plants evolved to cope with cold
3. Study shows Where Alzheimers starts and how it spreads
4. Study: Some plants may not adapt quickly to future climate change
5. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
6. Nutrition influences metabolism through circadian rhythms, UCI study finds
7. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
8. Deepwater Horizon NRDA study shows possible oil impact on dolphins
9. New study reveals the biomechanics of how marine snail larvae swim
10. Study finds Catalina Island Conservancy contraception program effectively manages bison population
11. Study led by NUS scientists provides new insights into cause of human neurodegenerative disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... have uncovered key steps involved in programmed cell death, ... lupus, cancers and neurodegenerative diseases. , The research ... together to discover the three-dimensional structure of a key ... steps in how it causes cell death. Their studies ... and Proceedings of the National Academy of ...
(Date:10/31/2014)... his team have been studying the behavior of ... Alps for years. They observed that ravens slowly ... and playing. However, they also observed that these ... individual. Although in about 50 % of the ... the two affiliating ravens, intervening can be potentially ...
(Date:10/30/2014)... help reduce or reverse soil subsidence and reduce ... Sacramento-San Joaquin River Delta by Dartmouth College researchers ... one of the first to continually measure the ... cycle through wetlands, appears in the journal by ... Worldwide, agricultural drainage of organic soils has resulted ...
Breaking Biology News(10 mins):A matter of life and death: Cell death proteins key to fighting disease 2Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2
... French . , Montreal, October 21, 2009 ... especially fear and disgust, according to a new study published ... As part of the investigation, Olivier Collignon and a team ... et cognition (CERNEC) demonstrated that women are better than men ...
... CHICAGO New research using animal models is ... drug addiction in humans knowledge that may lead ... cravings that cause people to relapse. The findings were ... annual meeting and the world,s largest source of emerging ...
... Atlanta, GA Current research suggests that latent cytomegalovirus ... related report by Onyeagocha et al, "Latent cytomegalovirus infection ... of The American Journal of Pathology . ... the United States. Most people who are infected ...
Cached Biology News:Women outperform men when identifying emotions 2Women outperform men when identifying emotions 3Studies improve knowledge of underlying brain changes caused by addiction 2The bowels of infection 2
(Date:10/31/2014)... 30, 2014 The evening of ... decades-long heritage in successful medical device development to ... what it takes to successfully innovate in the ... of a two-hour on-site class, Insight gave master’s ... business, McCormick School of Engineering, medical and law ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market by Type ... Channel (Supermarket, Health Store, Pharmacy, Convenience Store) & ... defines and segments the dairy alternative beverage market ... volume for plant-based dairy alternative beverages. , The ... by 2018 with the Asia-Pacific region as the ...
(Date:10/31/2014)... 2014  Atlanta-based Intellimedix could make a positive ... of Ebola by suggesting a new, computational approach ... Center for Computational Systems Biology have spent years ... uses for existing drugs through systematic repurposing, and ... bout against Ebola. Logo - ...
(Date:10/30/2014)... 30, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Naltrexone HCL information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
Breaking Biology Technology:Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... the first time observed chemical reactions near absolute zero, ... that reaction rates can be controlled using quantum mechanics, ... results and techniques, described in the Feb. 12 issue ... unknown aspects of how molecules interact, a key to ...
... , CINCINNATI , ... it will release its fourth quarter and full-year 2009 financial results after ... will host a telephone conference call and simultaneous webcast on Thursday, ... and answer session will follow. , Conference Call Instructions ...
... , , , ... /PRNewswire-Asia/ -- The January issue of,"Neuropharmacology", publishes the article ... (MLC 601) protective effects on neuronal and brain,injuries as well ... The French research team was led by Prof. ...
Cached Biology Technology:Seeing the quantum in chemistry: JILA scientists control chemical reactions of ultracold molecules 2Seeing the quantum in chemistry: JILA scientists control chemical reactions of ultracold molecules 3Seeing the quantum in chemistry: JILA scientists control chemical reactions of ultracold molecules 4Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 2Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 3Moleac Announces Breakthrough Results on Neuroprotective and Neurogenerative Properties of NeuroAiD 2Moleac Announces Breakthrough Results on Neuroprotective and Neurogenerative Properties of NeuroAiD 3
AC input: 50-60 Hz230 V...
... arraying proteins of interest with sensitive ... DiscoverLight Protein Array Kits allow for ... lysate or antibody in a low-density ... designed nitrocellulose membranes with a 384-grid ...
... hybridization of DNA or Protein microarrays printed ... glass slides. The proprietary design of the ... flatness, as is often the case with ... (67uL analytical cavity volume) eliminates the need ...
MAb to Myoglobin Cardiac...
Biology Products: