Navigation Links
Study finds a new culprit for epileptic seizures
Date:1/16/2013

archers are now exploring the link between glial calcium levels and neuronal excitability. One theory is that too much calcium produces a flood of neurotransmitters or other factors that glia normally secrete in a tightly regulated fashion. This unregulated secretion could hyperexcite the neurons, Littleton says.

"Glia are enlisted into the conversation that neurons are having, and they may modulate that by releasing these factors that control activity," Littleton says. "Elevated calcium may create a situation where the glia are no longer releasing these factors in a regulated way, but they're releasing them all the time."

In the human brain, astrocytes are the cells most similar to the fruit fly glial cells observed in this study, according to the researchers. These cells envelop the cell bodies of neurons and are also the most abundant type of glial cell in the human brain. It is not yet known whether these cells express one of the five human versions of the zydeco gene.

Although further study is needed, the findings suggest that preventing calcium from building up in glial cells or astrocytes could reduce neuronal excitability and decrease the tendency to seize in response to environmental stimuli, according to the researchers. "It's still a long way off, but the fly work suggests that reducing glial calcium levels would be effective in toning down excitability," Littleton says.

The MIT researchers are now looking for other components of the pathway that connects glial calcium levels to neuronal hyperactivity, which could lead to the discovery of other potential drug targets.


'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock
2. International study: Where theres smoke or smog, theres climate change
3. Born to lead? Leadership can be an inherited trait, study finds
4. CU-led study shows pine beetle outbreak buffers watersheds from nitrate pollution
5. UCI study reveals why Down syndrome boosts susceptibility to other conditions
6. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
7. UC Davis study deflates notion that pear-shaped bodies more healthy than apples
8. Rhythms in the brain help give a sense of location, study shows
9. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
10. New study identifies significance of co-infection in disease control
11. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... Research and ... addition of the "Digital Forensics Market ... (Computer Forensics, Network Forensics, Mobile Device Forensics, ... and Region - Global Forecast to 2020" ... By Component (Hardware, Software, and Service), Sub-Segment ...
(Date:7/31/2015)... -- Den 10. internationale konference om Genomik (ICG-10, ... 25. oktober i Shenzhen , Kina. ... år. Siden starten i 2006 er ICB blevet en ... er en af de mest dynamiske, entusiastiske og sjove ... gennembrud og fremskridt inden for ,omik,-forskning, som yderligere vil ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... COLUMBIA, Mo. About one in 3,500 people are ... retina,s visual cells that eventually leads to blindness. Now, ... link between cats and humans for two different forms ... therapies that will benefit both cats and humans. ...
... As researchers continue to examine the role ... people understand the differences among various ingredients used ... Association (CRA). Interchanging two distinctly different ingredients, such ... creates factually incorrect conclusions and misleads ,consumers. ...
... BEER-SHEVA, ISRAEL, March 4, 2009 Ben-Gurion University of ... plutonium created in large nuclear reactors, making it unsuitable ... (Am 241), a form of the basic synthetic element ... can only be used for peaceful purposes. , This ...
Cached Biology News:Cats' eye diseases genetically linked to diseases in humans 2Pure fructose frequently confused with high fructose corn syrup 2Ben-Gurion University engineers develop technique to help combat nuclear proliferation 2
(Date:8/27/2015)... , August 27, 2015 GlassesOff (OTCBB: ... processing functions in the human vision system, announced today a ... point guard Chris Paul to develop a new ... want to improve their real-life on-court performance. Vision ... whether it is shooting a ball or blocking a pass. ...
(Date:8/27/2015)... TRIANGLE PARK, N.C. , Aug. 27, 2015 ... on the decision by FedEx, UPS and The ... of certain biological specimens classified as ,select agents, ... and long history of handling these sensitive shipments. ... knowledge of global transportation regulations, trained and certified ...
(Date:8/26/2015)... , Aug. 26, 2015 /PRNewswire/ - iCo Therapeutics ("iCo" ... reported financial results for the quarter ended June ... in Canadian dollars and presented under International Financial ... activities with respect to our Oral Amp B ... contract manufacturer," said Andrew Rae , President ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
Breaking Biology Technology:Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4
... -- Prodesse, Inc. announced Monday that it ... completed a major process improvement to its ProFlu-1 assay. ... core investors, plus three new accredited individuals, have provided ... of a debt instrument convertible into equity at increasing ...
... knows that men and women truly are different. , ,Social ... come to the fore: around 80 percent of all autism ... differ greatly between the sexes - just about everyone agrees ... human development, critical brain proteins known as steroid receptors lay ...
... UW E-Business Consortium member spotlight series. Sub-Zero Freezer Company ... , ,People who are passionate about food tend ... consumers turn to is Madison, Wis.-based Sub-Zero Freezer Co. ... integrated to match a home's dcor, allowing customization to ...
Cached Biology Technology:Prodesse gets new funding; improves flu assay 2Gender hormones may lend to social disorder therapies 2How Sub-Zero Freezer Co. uses technology to revolutionize customer service 2How Sub-Zero Freezer Co. uses technology to revolutionize customer service 3
... can be used with all ... for stacking of covered plates ... use with automated systems ... non-ridged, are available for use ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... from an inert polymer with a unique split ... split septum caps for use with 384-well tall-chimney ... when used in conjunction with screw or clip-down ... pipetting equipment 384 septum caps may be ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
Biology Products: